PELP1 and TOM1L1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PELP1	TOM1L1
Gene Name		proline, glutamate and leucine rich protein 1	target of myb1 (chicken)-like 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Transcriptionally Active Chromatin MLL1 Complex	Cytoplasm Lysosome Endosome Golgi Stack Cytosol Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Chromatin Binding Protein Binding Transcription Factor Binding Poly(A) RNA Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding Clathrin Binding Protein Kinase Activator Activity Ubiquitin Binding
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Estrogen Stimulus	Intracellular Protein Transport Signal Transduction Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Mitotic Nuclear Division Regulation Of DNA Biosynthetic Process
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		20 interactors: AR BAG6 BLOC1S1 CREBBP EP300 ESR1 ESR2 HGS HIST1H1A HIST1H4A HIST2H2AC HIST2H2BE NFKB1 NR3C1 RB1 SMAD9 SNCA SRC STAT3 TOM1L1	27 interactors: AMFR CCDC47 CELF1 COPS7A CWF19L1 FAM208A FYN GLUD2 GRB2 GSN HGS HNRNPH1 MAP3K3 NDC80 NOMO1 PDPN PELP1 PHYH PIK3R1 PWP2 RAB18 TOLLIP TSG101 TUBA1B UBXN4 VAV2 VCP
Entrez ID		27043	10040
HPRD ID		10144	05266
Ensembl ID		ENSG00000141456	ENSG00000141198
Uniprot IDs		B4DEX7 B4DR36 E7EV54 I3L3A8 Q8IZL8	B7Z9E2 I3L4I4 O75674
PDB IDs			3RRU
Enriched GO Terms of Interacting Partners?		Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Cellular Response To Organic Cyclic Compound Response To Organic Cyclic Compound Chromatin Organization Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Response To Steroid Hormone Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Carbohydrate Metabolic Process Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Uterus Development Cell Communication Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Regulation Of Gene Expression Cellular Response To Hormone Stimulus Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Chromatin Modification Intracellular Estrogen Receptor Signaling Pathway Reproductive Process Response To Hormone Cellular Response To Organic Substance Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Lipid Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signaling DNA-templated Transcription, Initiation Tube Development Steroid Hormone Mediated Signaling Pathway Organelle Organization Negative Regulation Of Signal Transduction N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Signaling Peptidyl-lysine Acetylation Hormone-mediated Signaling Pathway	Phosphatidylinositol-mediated Signaling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Endoplasmic Reticulum Stress Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Platelet Activation Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Neurotrophin TRK Receptor Signaling Pathway T Cell Costimulation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Response To Organic Substance Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of RNA Splicing Fc Receptor Signaling Pathway ER-nucleus Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Wound Healing Response To Unfolded Protein Response To Stress Intracellular Signal Transduction Cellular Response To Organic Substance Cellular Component Assembly Immune Response-regulating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Complex Assembly Response To Wounding ER-associated Ubiquitin-dependent Protein Catabolic Process Blood Coagulation Hemostasis Cellular Response To Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Response To Fibroblast Growth Factor Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination NFAT Protein Import Into Nucleus Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of ERBB Signaling Pathway Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of T Cell Activation
Tagcloud ?		aacr autocrine branching cdk cdks coregulator demethylase deregulation facilitated gland glands hyper hyperbranching hyperplasia indicator kdm1 mammary mitogenic mmps mmtvrtta morphogenesis powerful precocious preneoplastic proto res tg tumorigenesis	adaptor behave bridged clathrin cytosolic defective egf egfr elusive endocytic endocytosis endosome engage exogenous grb2 incapable knocked machinery onto participate redistributes rescue rnai shc stimulates tail transient triggers tyr
Tagcloud (Difference) ?		aacr autocrine branching cdk cdks coregulator demethylase deregulation facilitated gland glands hyper hyperbranching hyperplasia indicator kdm1 mammary mitogenic mmps mmtvrtta morphogenesis powerful precocious preneoplastic proto res tg tumorigenesis	adaptor behave bridged clathrin cytosolic defective egf egfr elusive endocytic endocytosis endosome engage exogenous grb2 incapable knocked machinery onto participate redistributes rescue rnai shc stimulates tail transient triggers tyr
Tagcloud (Intersection) ?