TIAM2 and TNIK

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		TIAM2	TNIK
Gene Name		T-cell lymphoma invasion and metastasis 2	TRAF2 and NCK interacting kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Lamellipodium Filopodium Growth Cone Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Receptor Signaling Protein Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Cytoskeleton Organization Activation Of JNKK Activity Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Reorganization Intracellular Signal Transduction Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways		Rho GTPase cycle PPARA activates gene expression Signaling by GPCR GPCR downstream signaling Signalling by NGF Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Brain imaging in schizophrenia (interaction) ( 19023125) Coronary heart disease ( 21347282)
Protein-Protein Interactions		9 interactors: ANXA7 DISC1 DNM2 H2AFX PARD3 SH3GL2 TK1 TNIK UFD1L	38 interactors: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DISC1 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SLC9A1 SMARCE1 SNX6 SOS1 SPTBN1 SRGAP3 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1
Entrez ID		26230	23043
HPRD ID		05273	18206
Ensembl ID		ENSG00000146426	ENSG00000154310
Uniprot IDs		B3KW11 E9PKT1 Q8IVF5	Q9UKE5
PDB IDs			2X7F
Enriched GO Terms of Interacting Partners?		Membrane Organization Anatomical Structure Development Developmental Process Generation Of Neurons System Development Neurogenesis Multicellular Organismal Development Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Fetal Process Involved In Parturition Organelle Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Cell Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cell Projection Organization Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Nervous System Development Synaptic Vesicle Transport Negative Regulation Of Membrane Tubulation Skeletal Muscle Cell Proliferation Regulation Of Neuron Differentiation Cellular Localization Response To Stimulus Neuron Projection Morphogenesis Regulation Of Neurogenesis Cell Proliferation Response To Cortisol Apical Constriction Thymidine Metabolic Process Asymmetric Cell Division Establishment Of Vesicle Localization Vesicle Localization Deoxyribonucleoside Monophosphate Biosynthetic Process Neuron Projection Development Cell Projection Morphogenesis Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Development Cell Part Morphogenesis Activation Of JNKK Activity Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Cellular Component Assembly Protein Localization Positive Regulation Of Myelination Golgi Vesicle Transport Neuron Development Wnt Signaling Pathway	Neurogenesis Nervous System Development Cellular Component Assembly Movement Of Cell Or Subcellular Component Cell Differentiation Organelle Organization Generation Of Neurons Cytoskeleton Organization Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Locomotion Regulation Of Cell Projection Organization System Development Regulation Of Neuron Differentiation Anatomical Structure Development Endomembrane System Organization Regulation Of Cellular Component Size Signaling Multicellular Organismal Development Signal Transduction Cell Projection Organization Cell Communication Regulation Of Neurogenesis Cellular Localization Plasma Membrane Organization Regulation Of Signal Transduction Axonogenesis Developmental Process Positive Regulation Of Signal Transduction Axon Guidance Axon Development Cellular Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Cell Morphogenesis Protein Localization To Plasma Membrane Cell Projection Morphogenesis Membrane Organization Regulation Of Cell Development Regulation Of Signaling Cell Part Morphogenesis Neuron Projection Morphogenesis Neuron Differentiation Golgi To Plasma Membrane Protein Transport Anatomical Structure Morphogenesis Establishment Of Protein Localization To Plasma Membrane Establishment Or Maintenance Of Cell Polarity Cell Development Protein Localization To Organelle Cell Morphogenesis Involved In Differentiation
Tagcloud ?			a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt
Tagcloud (Difference) ?			a549 attenuation carboxamide competition continuing crosstalk docking efforts emerging emt fak focal hinge ky methylbenzamido motility nck orchestrated paxillin pharmacologic phenylamino smad tgf thiazole traf2 transforming triggers validate wnt
Tagcloud (Intersection) ?