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TIAM2 and H2AFX
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
TIAM2
H2AFX
Gene Name
T-cell lymphoma invasion and metastasis 2
H2A histone family, member X
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Membrane
Lamellipodium
Filopodium
Growth Cone
Extracellular Vesicular Exosome
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Molecular Function
Receptor Signaling Protein Activity
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Biological Process
Small GTPase Mediated Signal Transduction
Positive Regulation Of Rho GTPase Activity
Positive Regulation Of Apoptotic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Pathways
Rho GTPase cycle
PPARA activates gene expression
Signaling by GPCR
GPCR downstream signaling
Signalling by NGF
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Cell death signalling via NRAGE, NRIF and NADE
Signaling by Rho GTPases
NRAGE signals death through JNK
G alpha (12/13) signalling events
p75 NTR receptor-mediated signalling
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
9 interactors:
ANXA7
DISC1
DNM2
H2AFX
PARD3
SH3GL2
TK1
TNIK
UFD1L
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
Entrez ID
26230
3014
HPRD ID
05273
03465
Ensembl ID
ENSG00000146426
ENSG00000188486
Uniprot IDs
B3KW11
E9PKT1
Q8IVF5
P16104
PDB IDs
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
Enriched GO Terms of Interacting Partners
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Membrane Organization
Anatomical Structure Development
Developmental Process
Generation Of Neurons
System Development
Neurogenesis
Multicellular Organismal Development
Regulation Of Neuron Projection Development
Regulation Of Cellular Component Organization
Fetal Process Involved In Parturition
Organelle Localization
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Post-Golgi Vesicle-mediated Transport
Cell Differentiation
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Cell Projection Organization
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Organization
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Nervous System Development
Synaptic Vesicle Transport
Negative Regulation Of Membrane Tubulation
Skeletal Muscle Cell Proliferation
Regulation Of Neuron Differentiation
Cellular Localization
Response To Stimulus
Neuron Projection Morphogenesis
Regulation Of Neurogenesis
Cell Proliferation
Response To Cortisol
Apical Constriction
Thymidine Metabolic Process
Asymmetric Cell Division
Establishment Of Vesicle Localization
Vesicle Localization
Deoxyribonucleoside Monophosphate Biosynthetic Process
Neuron Projection Development
Cell Projection Morphogenesis
Antigen Processing And Presentation Of Peptide Antigen
Regulation Of Cell Development
Cell Part Morphogenesis
Activation Of JNKK Activity
Pyrimidine Nucleoside Salvage
Pyrimidine-containing Compound Salvage
Cellular Component Assembly
Protein Localization
Positive Regulation Of Myelination
Golgi Vesicle Transport
Neuron Development
Wnt Signaling Pathway
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
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Tagcloud (Intersection)
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