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TIAM2 and DNM2
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
TIAM2
DNM2
Gene Name
T-cell lymphoma invasion and metastasis 2
dynamin 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Membrane
Lamellipodium
Filopodium
Growth Cone
Extracellular Vesicular Exosome
Golgi Membrane
Cytoplasm
Golgi Apparatus
Cytosol
Microtubule
Plasma Membrane
Coated Pit
Focal Adhesion
Postsynaptic Density
Growth Cone
Midbody
Endocytic Vesicle Membrane
Postsynaptic Membrane
Extracellular Vesicular Exosome
Molecular Function
Receptor Signaling Protein Activity
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
GTPase Activity
Protein Binding
GTP Binding
Microtubule Binding
SH3 Domain Binding
Enzyme Binding
Biological Process
Small GTPase Mediated Signal Transduction
Positive Regulation Of Rho GTPase Activity
Positive Regulation Of Apoptotic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Transcription, DNA-templated
Post-Golgi Vesicle-mediated Transport
Endocytosis
Receptor-mediated Endocytosis
Signal Transduction
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Regulation Of Axon Extension
Receptor Internalization
Transferrin Transport
Positive Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Nitric Oxide Metabolic Process
Synaptic Vesicle Transport
Neuron Projection Morphogenesis
Regulation Of Nitric-oxide Synthase Activity
Membrane Organization
Negative Regulation Of Membrane Tubulation
Pathways
Rho GTPase cycle
PPARA activates gene expression
Signaling by GPCR
GPCR downstream signaling
Signalling by NGF
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Cell death signalling via NRAGE, NRIF and NADE
Signaling by Rho GTPases
NRAGE signals death through JNK
G alpha (12/13) signalling events
p75 NTR receptor-mediated signalling
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Retrograde neurotrophin signalling
Axon guidance
Gap junction degradation
Golgi Associated Vesicle Biogenesis
L1CAM interactions
Recycling pathway of L1
Clathrin derived vesicle budding
Lysosome Vesicle Biogenesis
Metabolism of nitric oxide
Gap junction trafficking and regulation
NOSTRIN mediated eNOS trafficking
MHC class II antigen presentation
eNOS activation and regulation
trans-Golgi Network Vesicle Budding
Innate Immune System
Formation of annular gap junctions
Signalling by NGF
Gap junction trafficking
NGF signalling via TRKA from the plasma membrane
Toll-Like Receptors Cascades
Toll Like Receptor 4 (TLR4) Cascade
Adaptive Immune System
Drugs
Diseases
GWAS
Coronary heart disease (
21347282
)
Protein-Protein Interactions
9 interactors:
ANXA7
DISC1
DNM2
H2AFX
PARD3
SH3GL2
TK1
TNIK
UFD1L
52 interactors:
AMPH
AOC1
AP2A1
APP
ATF7IP
ATXN3
BIN1
CCDC90B
CCR5
CCT7
CDK1
CTTN
DDX39B
DNM1
DYNC1I1
DYNLL1
EIF3L
EPS15
FNBP1
FNBP1L
GDF9
GRB2
HCK
HMGB1
ITSN1
ITSN2
KDR
MAN1B1
MANEA
MPHOSPH6
MPP6
PDE6G
PFN1
PPIB
PSTPIP1
PTK2
RPS2
RWDD2B
SH3GL2
SH3GLB1
SHANK1
SHANK2
SNX9
SPRY2
SRC
TIAM2
TRIP10
TYK2
VAV1
WBP4
ZBTB16
ZFAND6
Entrez ID
26230
1785
HPRD ID
05273
03852
Ensembl ID
ENSG00000146426
ENSG00000079805
Uniprot IDs
B3KW11
E9PKT1
Q8IVF5
P50570
Q8N1K8
PDB IDs
2YS1
Enriched GO Terms of Interacting Partners
?
Membrane Organization
Anatomical Structure Development
Developmental Process
Generation Of Neurons
System Development
Neurogenesis
Multicellular Organismal Development
Regulation Of Neuron Projection Development
Regulation Of Cellular Component Organization
Fetal Process Involved In Parturition
Organelle Localization
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Post-Golgi Vesicle-mediated Transport
Cell Differentiation
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Cell Projection Organization
Regulation Of Cell Morphogenesis
Regulation Of Cell Projection Organization
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Nervous System Development
Synaptic Vesicle Transport
Negative Regulation Of Membrane Tubulation
Skeletal Muscle Cell Proliferation
Regulation Of Neuron Differentiation
Cellular Localization
Response To Stimulus
Neuron Projection Morphogenesis
Regulation Of Neurogenesis
Cell Proliferation
Response To Cortisol
Apical Constriction
Thymidine Metabolic Process
Asymmetric Cell Division
Establishment Of Vesicle Localization
Vesicle Localization
Deoxyribonucleoside Monophosphate Biosynthetic Process
Neuron Projection Development
Cell Projection Morphogenesis
Antigen Processing And Presentation Of Peptide Antigen
Regulation Of Cell Development
Cell Part Morphogenesis
Activation Of JNKK Activity
Pyrimidine Nucleoside Salvage
Pyrimidine-containing Compound Salvage
Cellular Component Assembly
Protein Localization
Positive Regulation Of Myelination
Golgi Vesicle Transport
Neuron Development
Wnt Signaling Pathway
Endocytosis
Vesicle-mediated Transport
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Cellular Response To Growth Factor Stimulus
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Response To Growth Factor
Regulation Of ERBB Signaling Pathway
Movement Of Cell Or Subcellular Component
Locomotion
Cellular Response To Organic Substance
Chemotaxis
Cellular Localization
Regulation Of Signal Transduction
Regulation Of Signaling
Transport
Neurotrophin TRK Receptor Signaling Pathway
Viral Process
Positive Regulation Of Cellular Component Biogenesis
Peptidyl-tyrosine Autophosphorylation
Neurotrophin Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Protein Complex Assembly
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Establishment Of Localization In Cell
Regulation Of Cell Death
Negative Regulation Of ERBB Signaling Pathway
Neuron Projection Morphogenesis
Positive Regulation Of Protein Complex Assembly
Neuron Projection Development
Axon Guidance
Cell Projection Morphogenesis
Cell Part Morphogenesis
Regulation Of Cellular Component Organization
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Catalytic Activity
Response To Organic Substance
Nervous System Development
Neuron Development
Cell Projection Organization
Response To External Stimulus
Apoptotic Process
Cellular Component Assembly
Programmed Cell Death
Cell Migration
Immune System Process
Axonogenesis
Cell Death
Tagcloud
?
bcl11b
cadherin
discovered
druggable
exhibitedthe
fat1
fbxw7
frequencies
guide
harboured
herc1
jak
jak3
lymphoblastic
mll2
mutational
notch1
notch2
phf6
recurrent
regulators
reln
secretase
splicing
subclonal
unfavourable
warranted
wt1
zrsr2
Tagcloud (Difference)
?
bcl11b
cadherin
discovered
druggable
exhibitedthe
fat1
fbxw7
frequencies
guide
harboured
herc1
jak
jak3
lymphoblastic
mll2
mutational
notch1
notch2
phf6
recurrent
regulators
reln
secretase
splicing
subclonal
unfavourable
warranted
wt1
zrsr2
Tagcloud (Intersection)
?