TIAM2 and UFD1L

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TIAM2	UFD1L
Gene Name		T-cell lymphoma invasion and metastasis 2	ubiquitin fusion degradation 1 like (yeast)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Lamellipodium Filopodium Growth Cone Extracellular Vesicular Exosome	Nucleus Cytosol
	Molecular Function	Receptor Signaling Protein Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity	Ubiquitin-specific Protease Activity Receptor Binding Protein Binding Protein Complex Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Rho GTPase cycle PPARA activates gene expression Signaling by GPCR GPCR downstream signaling Signalling by NGF Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ANXA7 DISC1 DNM2 H2AFX PARD3 SH3GL2 TK1 TNIK UFD1L	19 interactors: A2M AMFR ANAPC2 F13A1 GZMK IGHM MASP1 NEDD8 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBXN6 VCP
Entrez ID		26230	7353
HPRD ID		05273	06778
Ensembl ID		ENSG00000146426	ENSG00000070010
Uniprot IDs		B3KW11 E9PKT1 Q8IVF5	Q541A5 Q92890
PDB IDs			2YUJ
Enriched GO Terms of Interacting Partners?		Membrane Organization Anatomical Structure Development Developmental Process Generation Of Neurons System Development Neurogenesis Multicellular Organismal Development Regulation Of Neuron Projection Development Regulation Of Cellular Component Organization Fetal Process Involved In Parturition Organelle Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Cell Differentiation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cell Projection Organization Regulation Of Cell Morphogenesis Regulation Of Cell Projection Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Nervous System Development Synaptic Vesicle Transport Negative Regulation Of Membrane Tubulation Skeletal Muscle Cell Proliferation Regulation Of Neuron Differentiation Cellular Localization Response To Stimulus Neuron Projection Morphogenesis Regulation Of Neurogenesis Cell Proliferation Response To Cortisol Apical Constriction Thymidine Metabolic Process Asymmetric Cell Division Establishment Of Vesicle Localization Vesicle Localization Deoxyribonucleoside Monophosphate Biosynthetic Process Neuron Projection Development Cell Projection Morphogenesis Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Development Cell Part Morphogenesis Activation Of JNKK Activity Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Cellular Component Assembly Protein Localization Positive Regulation Of Myelination Golgi Vesicle Transport Neuron Development Wnt Signaling Pathway	Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Complement Activation ER-nucleus Signaling Pathway Response To Growth Factor Regulation Of Fibroblast Apoptotic Process Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Response To Endoplasmic Reticulum Stress Blood Coagulation Hemostasis Regulation Of Complement Activation Cellular Response To Organic Substance Response To Organic Substance Platelet Activation Regulation Of Proteasomal Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Response To Stress Neurotrophin TRK Receptor Signaling Pathway Vesicle-mediated Transport Neurotrophin Signaling Pathway Regulation Of Humoral Immune Response Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Regulation Of Body Fluid Levels Protein Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Wound Healing Positive Regulation Of Cell Death Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process
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