TIAM2

Description		TIAM Rac1 associated GEF 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Lamellipodium Filopodium Growth Cone Cell Projection Neuron Projection Perikaryon Synapse Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity
	Biological Process	Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Signal Transduction Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK PPARA activates gene expression G alpha (12/13) signalling events RAC1 GTPase cycle
Drugs
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Appendicular lean mass ( 33097823) Asthma ( 31361310) Dimensional psychopathology (Arousal) ( 29496196) Dimensional psychopathology (Negative) ( 29496196) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Lipoprotein (a) levels ( 26377243) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		9 interacting genes: ANXA7 DISC1 DNM2 H2AX PARD3 SH3GL2 TK1 TNIK UFD1
Entrez ID		26230
HPRD ID		05273
Ensembl ID		ENSG00000146426
Uniprot IDs		B3KW11 Q8IVF5
PDB IDs
Enriched GO Terms of Interacting Partners?		Presynapse Cytoskeleton Organization Cell Projection Organization Developmental Process Cell Projection Morphogenesis Neuron Projection Morphogenesis Negative Regulation Of Membrane Tubulation Actin Filament-based Process Intracellular Protein Localization Vesicle Scission Regulation Of Axon Extension Actin Cytoskeleton Organization Phosphatidylinositol-4,5-bisphosphate Binding Thymidine Kinase Activity UFD1-NPL4 Complex Negative Regulation Of Blood-brain Barrier Permeability System Development DNA Synthesis Involved In Mitotic DNA Replication Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone Negative Regulation Of Gene Expression Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Recycling Endosome Protein-containing Complex Assembly Glutamatergic Synapse Thymidine Biosynthetic Process Positive Regulation Of Microvillus Assembly Internode Region Of Axon Negative Regulation Of Peptidyl-threonine Phosphorylation
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