HES1 and HEY2

Number of citations of the paper that reports this interaction (PubMedID 11486045)
50

Data Source:
HPRD (in vitro, in vivo)

		HES1	HEY2
Description		hes family bHLH transcription factor 1	hes related family bHLH transcription factor with YRPW motif 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Protein-containing Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding JUN Kinase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding HLH Domain Binding Sequence-specific DNA Binding Protein-containing Complex Binding Protein Dimerization Activity Protein-folding Chaperone Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding N-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Liver Development Inhibition Of Neuroepithelial Cell Differentiation Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Ventricular Septum Development Pancreatic A Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Adhesion Notch Signaling Pathway Smoothened Signaling Pathway Pattern Specification Process Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Virus Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Cell Migration Telencephalon Development Midbrain-hindbrain Boundary Morphogenesis Oculomotor Nerve Development Trochlear Nerve Development Hindbrain Morphogenesis Forebrain Radial Glial Cell Differentiation Cajal-Retzius Cell Differentiation Neural Tube Development Central Nervous System Neuron Differentiation Pituitary Gland Development Adenohypophysis Development Neuron Differentiation Lung Development BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Midbrain Development Pancreas Development Somatic Stem Cell Population Maintenance Hair Cell Differentiation Amacrine Cell Differentiation Aorta Morphogenesis Ascending Aorta Morphogenesis T Cell Proliferation Positive Regulation Of T Cell Proliferation Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Protein-containing Complex Assembly Response To Alkaloid Positive Regulation Of DNA Binding Cell Fate Commitment Negative Regulation Of Cell Differentiation Regulation Of Fat Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Glial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitotic Cell Cycle, Embryonic Lateral Inhibition Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Maturation Regulation Of Timing Of Cell Differentiation Thymus Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Artery Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Inner Ear Receptor Cell Stereocilium Organization Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Glial Cell Proliferation Ventricular Septum Morphogenesis Ureteric Bud Morphogenesis Labyrinthine Layer Blood Vessel Development Common Bile Duct Development Neuroendocrine Cell Differentiation Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Pharyngeal Arch Artery Morphogenesis Protein-containing Complex Assembly Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Fatty Acid Glomerulus Vasculature Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Interstitial Fibroblast Development Metanephric Nephron Tubule Morphogenesis Cochlea Development Establishment Of Epithelial Cell Polarity Negative Regulation Of Calcium Ion Import Response To Thyroid Hormone Vascular Associated Smooth Muscle Cell Development Neuronal Stem Cell Population Maintenance Negative Regulation Of Amacrine Cell Differentiation Response To Aroclor 1254 Negative Regulation Of Cell Fate Determination Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Pancreatic A Cell Differentiation Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Vasculogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Valve Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Tricuspid Valve Morphogenesis Tricuspid Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cardiac Ventricle Morphogenesis Cardiac Left Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cardiac Muscle Hypertrophy Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Pattern Specification Process Heart Development Anatomical Structure Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Positive Regulation Of Heart Rate Regulation Of Gene Expression Negative Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Mesenchymal Cell Development Cardiac Muscle Hypertrophy In Response To Stress Ascending Aorta Morphogenesis Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Cell Fate Commitment Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Smooth Muscle Cell Differentiation Negative Regulation Of Smooth Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Development Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Negative Regulation Of Transcription Initiation By RNA Polymerase II Labyrinthine Layer Blood Vessel Development Blood Vessel Endothelial Cell Differentiation Artery Development Arterial Endothelial Cell Differentiation Cardiac Vascular Smooth Muscle Cell Development Coronary Vasculature Morphogenesis Pulmonary Artery Morphogenesis Protein-DNA Complex Assembly Negative Regulation Of Biomineral Tissue Development Circulatory System Development Cochlea Development Vascular Associated Smooth Muscle Cell Development Negative Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis
Pathways		Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Thyroid stimulating hormone levels ( 30367059 32769997)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Brugada syndrome ( 23872634 35210625 32619740) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 27135401 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometrial endometrioid carcinoma ( 27135401) Midgestational circulating levels of PCBs (fetal genetic effect) ( 28235828) Migraine ( 27322543) Night sleep phenotypes ( 27126917) Serum metabolite concentrations in chronic kidney disease ( 33838163) Subcortical volume (MOSTest) ( 32665545) TPE interval (resting) ( 32386560) Waist-hip index ( 34021172)
Interacting Genes		36 interacting genes: ALK APCS APH1A ASGR2 CSNK1E FANCA FANCE FANCF FANCG FANCL FHL1 FOXG1 GAPDH HDAC6 HES6 HEY2 HMGB1 HMGCL ID1 ID2 ID3 ID4 JAK2 LTBR NHLH2 NR4A1 NUDT3 PRKCA PTK2 RUNX2 SIRT1 STAT3 TLE1 TLE2 UBQLN1 YWHAB	27 interacting genes: ARNT ATXN1 CYSRT1 ENO1 FHL5 HAND1 HAND2 HDAC1 HES1 HOXA1 HSF2BP KRTAP1-1 KRTAP11-1 KRTAP3-1 KRTAP4-4 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP8-1 NCOR1 PDLIM7 PLSCR1 RBPMS SIN3A SIRT1 TRAF1 TRAF4
Entrez ID		3280	23493
HPRD ID		00770	05243
Ensembl ID		ENSG00000114315	ENSG00000135547
Uniprot IDs		Q14469	Q5TF93 Q9UBP5
PDB IDs		2MH3 7C4O
Enriched GO Terms of Interacting Partners?		Fanconi Anaemia Nuclear Complex Regulation Of Cell Differentiation Transcription Regulator Inhibitor Activity Nucleus Protein Dimerization Activity Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Population Proliferation Interstrand Cross-link Repair Animal Organ Development Negative Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Developmental Process Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Nucleoplasm Cell Differentiation Regulation Of Developmental Process Circadian Rhythm Regulation Of Primary Metabolic Process Regulation Of Multicellular Organismal Development Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Transcription Regulator Complex Neuron Differentiation Rhythmic Process Animal Organ Morphogenesis Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Positive Regulation Of Endothelial Cell Proliferation Regulation Of Signal Transduction Negative Regulation Of Developmental Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Response To Stress Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Anatomical Structure Morphogenesis	Intermediate Filament RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Regulation Of Androgen Receptor Signaling Pathway Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis HLH Domain Binding Cardiac Right Ventricle Formation Keratin Filament Chromatin Regulation Of Transcription By RNA Polymerase II Cytosol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Identical Protein Binding Histone Deacetylase Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Cardiac Neural Crest Cell Development Involved In Heart Development Regulation Of Secondary Heart Field Cardioblast Proliferation Determination Of Heart Left/right Asymmetry Transcription Corepressor Binding Cardiac Ventricle Formation Negative Regulation Of Transcription By RNA Polymerase II Cartilage Morphogenesis E-box Binding Regulation Of Cardioblast Proliferation Thioesterase Binding Positive Regulation Of Phosphate Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gliogenesis Transcription Repressor Complex Artery Morphogenesis Cardiac Chamber Formation Protein Dimerization Activity Regulation Of Cellular Response To Growth Factor Stimulus DNA Binding Protein Deacetylation Protein Lysine Deacetylase Activity Odontogenesis Of Dentin-containing Tooth Embryonic Heart Tube Morphogenesis Regulation Of Phosphorus Metabolic Process Regulation Of ATP Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Purine Nucleotide Metabolic Process
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