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HES1 and NUDT3
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
HES1
NUDT3
Gene Name
hes family bHLH transcription factor 1
nudix (nucleoside diphosphate linked moiety X)-type motif 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Extracellular Vesicular Exosome
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
Sequence-specific DNA Binding
Chaperone Binding
N-box Binding
Magnesium Ion Binding
Diphosphoinositol-polyphosphate Diphosphatase Activity
Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity
Inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate Diphosphatase Activity
Inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate Diphosphatase Activity
Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity
Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase Activity
Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity
Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Liver Development
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Transcription From RNA Polymerase II Promoter
Protein Complex Assembly
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
STAT Protein Import Into Nucleus
Nervous System Development
Positive Regulation Of Cell Proliferation
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Adenohypophysis Development
Lung Development
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Endocrine Pancreas Development
Somatic Stem Cell Maintenance
Ascending Aorta Morphogenesis
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Auditory Receptor Cell Fate Determination
Positive Regulation Of DNA Binding
Regulation Of Fat Cell Differentiation
Negative Regulation Of Auditory Receptor Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Positive Regulation Of JAK-STAT Cascade
Cell Maturation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Vascular Smooth Muscle Cell Development
Neuronal Stem Cell Maintenance
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Cell-cell Signaling
Diadenosine Polyphosphate Catabolic Process
Inositol Phosphate Metabolic Process
Small Molecule Metabolic Process
Diphosphoinositol Polyphosphate Catabolic Process
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH
NOTCH2 intracellular domain regulates transcription
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
NOTCH1 Intracellular Domain Regulates Transcription
Signaling by NOTCH2
Regulation of beta-cell development
Signaling by NOTCH1
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Synthesis of pyrophosphates in the cytosol
Inositol phosphate metabolism
Drugs
Diseases
GWAS
Body mass index (
20935630
)
Height (
19893584
)
Protein-Protein Interactions
33 interactors:
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NR4A1
NUDT3
PRKCA
PTK2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
36 interactors:
ALAS1
APEX1
ARL6IP1
ASB13
CCL11
CHCHD3
DBN1
DDR1
DNAJA1
EEF1G
FXYD3
HES1
ITFG1
MAF1
MCM5
MEX3B
NR2C1
NUDT5
OAT
PDCD5
PEX5
PRKD3
RAB17
REEP5
RNF126
RPL17
RPL8
RPLP1
SOX30
TNNT3
TUBA1A
TUBGCP4
UBR1
VPS51
WDR74
XPNPEP1
Entrez ID
3280
11165
HPRD ID
00770
14849
Ensembl ID
ENSG00000114315
Uniprot IDs
Q14469
O95989
PDB IDs
2FVV
2Q9P
Enriched GO Terms of Interacting Partners
?
System Development
Organ Development
Multicellular Organismal Development
Response To Stress
Anatomical Structure Development
Regulation Of Cell Death
Negative Regulation Of Biosynthetic Process
Developmental Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Apoptotic Process
Response To Stimulus
Rhythmic Process
Cellular Metabolic Process
Cellular Response To Stimulus
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cell Differentiation
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Nitrogen Compound Metabolic Process
Circadian Rhythm
Regulation Of DNA Binding
Cellular Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Cellular Response To Stress
Negative Regulation Of Cell Differentiation
Apoptotic Process
Negative Regulation Of DNA Binding
Regulation Of Cell Differentiation
Programmed Cell Death
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cell Death
Death
Regulation Of Osteoblast Differentiation
Positive Regulation Of Apoptotic Process
DNA Repair
Response To Growth Factor
Anatomical Structure Morphogenesis
Regulation Of Cell Proliferation
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Response To External Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression
Negative Regulation Of Cell Death
Protein Targeting To Membrane
Cotranslational Protein Targeting To Membrane
Establishment Of Protein Localization To Membrane
Cellular Metabolic Process
Protein Targeting
Intracellular Transport
Protein Localization To Organelle
Cellular Localization
Cellular Protein Localization
Translational Elongation
Establishment Of Protein Localization To Organelle
Catabolic Process
Protein Localization To Membrane
Protein Localization
Intracellular Protein Transport
Viral Transcription
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
SRP-dependent Cotranslational Protein Targeting To Membrane
Cellular Process
Establishment Of Localization In Cell
Protein Targeting To ER
Cytoplasmic Transport
Aromatic Compound Catabolic Process
Establishment Of Protein Localization To Endoplasmic Reticulum
Protein Transport
Protein Localization To Endoplasmic Reticulum
DNA Strand Elongation Involved In DNA Replication
Establishment Of Protein Localization
Branching Involved In Mammary Gland Duct Morphogenesis
DNA Strand Elongation
Translational Termination
Membrane Organization
Cellular Macromolecule Catabolic Process
Nuclear-transcribed MRNA Catabolic Process
Metabolic Process
MRNA Catabolic Process
Transcription Factor TFIIIB Complex Assembly
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Negative Regulation Of Pancreatic A Cell Differentiation
Cytoplasm-associated Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pharyngeal Arch Artery Morphogenesis
Lateral Inhibition
Positive Regulation Of Protein Import Into Mitochondrial Outer Membrane
Negative Regulation Of Chaperone-mediated Protein Folding
Mammary Gland Duct Morphogenesis
RNA Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Interleukin-4
Cellular Protein Complex Disassembly
Viral Life Cycle
Tagcloud
?
alterations
anatomic
astrocytoma
astrocytomas
biology
braf
grade
hey1
hey2
implicated
inhibiting
interference
much
needed
neoplastic
notch
notch1
notch2
overexpressed
pa
pas
pediatric
pilocytic
res186
res259
secretase
tumorigenesis
variable
viable
Tagcloud (Difference)
?
alterations
anatomic
astrocytoma
astrocytomas
biology
braf
grade
hey1
hey2
implicated
inhibiting
interference
much
needed
neoplastic
notch
notch1
notch2
overexpressed
pa
pas
pediatric
pilocytic
res186
res259
secretase
tumorigenesis
variable
viable
Tagcloud (Intersection)
?