Wiki-Pi
About
Search
People
Updates
Search
HES1 and APH1A
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
HES1
APH1A
Description
hes family bHLH transcription factor 1
aph-1A gamma-secretase subunit
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Matrix
Protein-containing Complex
Golgi Membrane
Early Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Synaptic Vesicle
Endosome Membrane
Membrane
Golgi Cisterna Membrane
Presynaptic Membrane
Gamma-secretase Complex
Synaptic Membrane
Molecular Function
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity
Transcription Corepressor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Protein Binding
JUN Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
HLH Domain Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
Protein Dimerization Activity
Protein-folding Chaperone Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
E-box Binding
N-box Binding
Sequence-specific Double-stranded DNA Binding
Protein Binding
Enzyme Binding
Protein-macromolecule Adaptor Activity
Endopeptidase Activator Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Cell Fate Determination
Liver Development
Inhibition Of Neuroepithelial Cell Differentiation
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Pancreatic A Cell Differentiation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
Pattern Specification Process
Nervous System Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Response To Virus
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Neuron Projection Development
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Cajal-Retzius Cell Differentiation
Neural Tube Development
Central Nervous System Neuron Differentiation
Pituitary Gland Development
Adenohypophysis Development
Neuron Differentiation
Lung Development
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Pancreas Development
Somatic Stem Cell Population Maintenance
Hair Cell Differentiation
Amacrine Cell Differentiation
Aorta Morphogenesis
Ascending Aorta Morphogenesis
T Cell Proliferation
Positive Regulation Of T Cell Proliferation
Inner Ear Auditory Receptor Cell Differentiation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Protein-containing Complex Assembly
Response To Alkaloid
Positive Regulation Of DNA Binding
Cell Fate Commitment
Negative Regulation Of Cell Differentiation
Regulation Of Fat Cell Differentiation
Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation
Regulation Of Neuron Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Glial Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Cell Maturation
Regulation Of Timing Of Cell Differentiation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Epithelial Cell Proliferation
Regulation Of Neurogenesis
Negative Regulation Of Neurogenesis
Inner Ear Receptor Cell Stereocilium Organization
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Neuroendocrine Cell Differentiation
Stomach Neuroendocrine Cell Differentiation
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Protein-containing Complex Assembly
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Fatty Acid
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Establishment Of Epithelial Cell Polarity
Negative Regulation Of Calcium Ion Import
Response To Thyroid Hormone
Vascular Associated Smooth Muscle Cell Development
Neuronal Stem Cell Population Maintenance
Negative Regulation Of Amacrine Cell Differentiation
Response To Aroclor 1254
Negative Regulation Of Cell Fate Determination
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Negative Regulation Of Inner Ear Receptor Cell Differentiation
Metanephros Development
Proteolysis
Membrane Protein Ectodomain Proteolysis
Notch Signaling Pathway
Notch Receptor Processing
Protein Processing
Membrane Protein Intracellular Domain Proteolysis
Amyloid-beta Formation
Amyloid Precursor Protein Metabolic Process
Amyloid Precursor Protein Catabolic Process
Pathways
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Amyloid fiber formation
TGFBR3 PTM regulation
Drugs
E-2012
MK-0752
Diseases
GWAS
Alcoholic chronic pancreatitis (
28754779
)
Dental caries (decayed, missing and filled teeth) (
31533690
)
Dental caries (decayed, missing and filled tooth surfaces) (
31533690
)
Thyroid stimulating hormone levels (
30367059
32769997
)
Bipolar disorder (
31043756
)
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Chronotype (
26955885
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Morning vs. evening chronotype (
26835600
26955885
)
Refractive error (
32231278
)
Schizophrenia (
25056061
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
36 interacting genes:
ALK
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NHLH2
NR4A1
NUDT3
PRKCA
PTK2
RUNX2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
36 interacting genes:
ANKRD46
APOD
ASGR1
ATF4
BHLHE40
CREB3
DRD2
FIS1
FXYD6
GLP1R
GPATCH8
GPR35
HES1
HIVEP1
IGFBP5
KLF11
LAT
MFSD6
MPP1
MRAP2
NCSTN
PSEN1
PSEN2
PSENEN
RBFOX2
SCAND1
SERP1
SLC38A7
SLC39A9
SMAGP
THPO
TLE1
TMED10
TMEM140
TMEM218
TRARG1
Entrez ID
3280
51107
HPRD ID
00770
06360
Ensembl ID
ENSG00000114315
ENSG00000117362
Uniprot IDs
Q14469
B4DUG7
Q96BI3
PDB IDs
2MH3
7C4O
5A63
5FN2
5FN3
5FN4
5FN5
6IDF
6IYC
6LQG
6LR4
7C9I
7D8X
7Y5T
7Y5X
7Y5Z
8IM7
8K8E
8KCO
8KCP
8KCS
8KCT
8KCU
8X52
8X53
8X54
Enriched GO Terms of Interacting Partners
?
Fanconi Anaemia Nuclear Complex
Regulation Of Cell Differentiation
Transcription Regulator Inhibitor Activity
Nucleus
Protein Dimerization Activity
Transcription Corepressor Activity
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cell Population Proliferation
Interstrand Cross-link Repair
Animal Organ Development
Negative Regulation Of RNA Metabolic Process
Regulation Of Cell Population Proliferation
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cell Differentiation
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Chromatin
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Cellular Developmental Process
Developmental Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Epithelial Cell Proliferation
Nucleoplasm
Cell Differentiation
Regulation Of Developmental Process
Circadian Rhythm
Regulation Of Primary Metabolic Process
Regulation Of Multicellular Organismal Development
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Development
Transcription Regulator Complex
Neuron Differentiation
Rhythmic Process
Animal Organ Morphogenesis
Positive Regulation Of Cell Differentiation
Positive Regulation Of Developmental Process
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of Signal Transduction
Negative Regulation Of Developmental Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of Apoptotic Process
Response To Stress
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Gene Expression
Anatomical Structure Morphogenesis
Gamma-secretase Complex
Notch Receptor Processing
Amyloid-beta Formation
Amyloid Precursor Protein Catabolic Process
Membrane Protein Ectodomain Proteolysis
Amyloid-beta Metabolic Process
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Amyloid Precursor Protein Metabolic Process
Presynaptic Membrane
Membrane Protein Proteolysis
Notch Signaling Pathway
Cajal-Retzius Cell Differentiation
Regulation Of Metal Ion Transport
Regulation Of Monoatomic Ion Transport
Cell Surface Receptor Signaling Pathway
Growth Factor Receptor Binding
Regulation Of Transport
Adenohypophysis Development
Positive Regulation Of Growth Hormone Secretion
Membrane
CAMP Response Element Binding Protein Binding
Regulation Of Protein Metabolic Process
Negative Regulation Of Transport
Homeostatic Process
Regulation Of Growth Hormone Secretion
Membrane Protein Intracellular Domain Proteolysis
Golgi Membrane
Synaptic Membrane
Endoplasmic Reticulum Unfolded Protein Response
Circadian Regulation Of Gene Expression
Cellular Response To Oxygen-containing Compound
Signal Transduction
Vesicle Targeting
Epithelial Cell Proliferation
Protein Processing
Endopeptidase Activator Activity
Regulation Of Primary Metabolic Process
Regulation Of Synaptic Plasticity
G Protein-coupled Dopamine Receptor Signaling Pathway
Cerebral Cortex Neuron Differentiation
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?