HES1 and APCS

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		HES1	APCS
Description		hes family bHLH transcription factor 1	amyloid P component, serum
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Protein-containing Complex	Extracellular Region Extracellular Space Nucleus Extracellular Exosome Blood Microparticle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding JUN Kinase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding HLH Domain Binding Sequence-specific DNA Binding Protein-containing Complex Binding Protein Dimerization Activity Protein-folding Chaperone Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding N-box Binding Sequence-specific Double-stranded DNA Binding	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Identical Protein Binding Virion Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Cell Fate Determination Liver Development Inhibition Of Neuroepithelial Cell Differentiation Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Ventricular Septum Development Pancreatic A Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Adhesion Notch Signaling Pathway Smoothened Signaling Pathway Pattern Specification Process Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Virus Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Cell Migration Telencephalon Development Midbrain-hindbrain Boundary Morphogenesis Oculomotor Nerve Development Trochlear Nerve Development Hindbrain Morphogenesis Forebrain Radial Glial Cell Differentiation Cajal-Retzius Cell Differentiation Neural Tube Development Central Nervous System Neuron Differentiation Pituitary Gland Development Adenohypophysis Development Neuron Differentiation Lung Development BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Midbrain Development Pancreas Development Somatic Stem Cell Population Maintenance Hair Cell Differentiation Amacrine Cell Differentiation Aorta Morphogenesis Ascending Aorta Morphogenesis T Cell Proliferation Positive Regulation Of T Cell Proliferation Inner Ear Auditory Receptor Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Protein-containing Complex Assembly Response To Alkaloid Positive Regulation Of DNA Binding Cell Fate Commitment Negative Regulation Of Cell Differentiation Regulation Of Fat Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Glial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitotic Cell Cycle, Embryonic Lateral Inhibition Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Maturation Regulation Of Timing Of Cell Differentiation Thymus Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Artery Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Inner Ear Receptor Cell Stereocilium Organization Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Glial Cell Proliferation Ventricular Septum Morphogenesis Ureteric Bud Morphogenesis Labyrinthine Layer Blood Vessel Development Common Bile Duct Development Neuroendocrine Cell Differentiation Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Pharyngeal Arch Artery Morphogenesis Protein-containing Complex Assembly Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Fatty Acid Glomerulus Vasculature Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Interstitial Fibroblast Development Metanephric Nephron Tubule Morphogenesis Cochlea Development Establishment Of Epithelial Cell Polarity Negative Regulation Of Calcium Ion Import Response To Thyroid Hormone Vascular Associated Smooth Muscle Cell Development Neuronal Stem Cell Population Maintenance Negative Regulation Of Amacrine Cell Differentiation Response To Aroclor 1254 Negative Regulation Of Cell Fate Determination Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Pancreatic A Cell Differentiation Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Host-mediated Suppression Of Symbiont Invasion Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Glycoprotein Metabolic Process
Pathways		Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	Amyloid fiber formation
Drugs			Zinc Methyl 4,6-O-[(1R)-1-carboxyethylidene]-beta-D-galactopyranoside Bis-1,2-{[(Z)-2-carboxy-2-methyl-1,3-dioxane]-5-yloxycarbamoyl}-ethane BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE Copper Zinc acetate
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Thyroid stimulating hormone levels ( 30367059 32769997)	Blood protein levels ( 30072576) C-reactive protein ( 22939635) Neonatal white matter microstructure ( 33009551)
Interacting Genes		36 interacting genes: ALK APCS APH1A ASGR2 CSNK1E FANCA FANCE FANCF FANCG FANCL FHL1 FOXG1 GAPDH HDAC6 HES6 HEY2 HMGB1 HMGCL ID1 ID2 ID3 ID4 JAK2 LTBR NHLH2 NR4A1 NUDT3 PRKCA PTK2 RUNX2 SIRT1 STAT3 TLE1 TLE2 UBQLN1 YWHAB	18 interacting genes: ALX1 C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG
Entrez ID		3280	325
HPRD ID		00770	00101
Ensembl ID		ENSG00000114315	ENSG00000132703
Uniprot IDs		Q14469	P02743 V9HWP0
PDB IDs		2MH3 7C4O	1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU
Enriched GO Terms of Interacting Partners?		Fanconi Anaemia Nuclear Complex Regulation Of Cell Differentiation Transcription Regulator Inhibitor Activity Nucleus Protein Dimerization Activity Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Population Proliferation Interstrand Cross-link Repair Animal Organ Development Negative Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cellular Developmental Process Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Nucleoplasm Cell Differentiation Regulation Of Developmental Process Circadian Rhythm Regulation Of Primary Metabolic Process Regulation Of Multicellular Organismal Development Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Transcription Regulator Complex Neuron Differentiation Rhythmic Process Animal Organ Morphogenesis Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Positive Regulation Of Endothelial Cell Proliferation Regulation Of Signal Transduction Negative Regulation Of Developmental Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Apoptotic Process Response To Stress Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Anatomical Structure Morphogenesis	IgG Binding IgG Receptor Activity Acute Inflammatory Response Antibody-dependent Cellular Cytotoxicity Hypersensitivity Acute Inflammatory Response To Antigenic Stimulus Lymphocyte Mediated Immunity Immune Effector Process Leukocyte Mediated Immunity Leukocyte Mediated Cytotoxicity Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Fc Receptor Signaling Pathway Low-affinity IgG Receptor Activity Cell Killing Defense Response Response To Other Organism Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Adaptive Immune Response Extracellular Region Immune Response Inflammatory Response Retinal Blood Vessel Morphogenesis Response To External Biotic Stimulus Regulation Of Immune Response Innate Immune Response Immune System Process Positive Regulation Of Immune System Process Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Lymphocyte Mediated Immunity Retina Vasculature Morphogenesis In Camera-type Eye Immune Response-regulating Signaling Pathway Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Defense Response To Other Organism Basement Membrane Regulation Of Mononuclear Cell Proliferation Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Acute Inflammatory Response To Antigenic Stimulus Renal Tubule Morphogenesis Blood Vessel Morphogenesis Regulation Of Leukocyte Proliferation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Leukocyte Activation Extracellular Matrix Structural Constituent
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