HES1 and LTBR

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HES1	LTBR
Gene Name		hes family bHLH transcription factor 1	lymphotoxin beta receptor (TNFR superfamily, member 3)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Chaperone Binding N-box Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Ventricular Septum Development Transcription From RNA Polymerase II Promoter Protein Complex Assembly Cell Adhesion Notch Signaling Pathway Smoothened Signaling Pathway STAT Protein Import Into Nucleus Nervous System Development Positive Regulation Of Cell Proliferation Cell Migration Telencephalon Development Midbrain-hindbrain Boundary Morphogenesis Oculomotor Nerve Development Trochlear Nerve Development Hindbrain Morphogenesis Forebrain Radial Glial Cell Differentiation Adenohypophysis Development Lung Development Positive Regulation Of BMP Signaling Pathway Midbrain Development Endocrine Pancreas Development Somatic Stem Cell Maintenance Ascending Aorta Morphogenesis Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Auditory Receptor Cell Fate Determination Positive Regulation Of DNA Binding Regulation Of Fat Cell Differentiation Negative Regulation Of Auditory Receptor Cell Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Mitotic Cell Cycle, Embryonic Lateral Inhibition Positive Regulation Of JAK-STAT Cascade Cell Maturation Thymus Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Artery Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Glial Cell Proliferation Ventricular Septum Morphogenesis Ureteric Bud Morphogenesis Labyrinthine Layer Blood Vessel Development Common Bile Duct Development Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Pharyngeal Arch Artery Morphogenesis Glomerulus Vasculature Development Comma-shaped Body Morphogenesis S-shaped Body Morphogenesis Renal Interstitial Fibroblast Development Metanephric Nephron Tubule Morphogenesis Cochlea Development Vascular Smooth Muscle Cell Development Neuronal Stem Cell Maintenance Negative Regulation Of Pancreatic A Cell Differentiation Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation	Apoptotic Process Signal Transduction Viral Process Myeloid Dendritic Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Regulation of beta-cell development Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: APCS APH1A ASGR2 CSNK1E FANCA FANCE FANCF FANCG FANCL FHL1 FOXG1 GAPDH HDAC6 HES6 HEY2 HMGB1 HMGCL ID1 ID2 ID3 ID4 JAK2 LTBR NR4A1 NUDT3 PRKCA PTK2 SIRT1 STAT3 TLE1 TLE2 UBQLN1 YWHAB	13 interactors: BIRC2 DIABLO HES1 LTA LTB TNFSF14 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRIM37 ZMYND11
Entrez ID		3280	4055
HPRD ID		00770	02988
Ensembl ID		ENSG00000114315	ENSG00000111321
Uniprot IDs		Q14469	P36941
PDB IDs			1RF3
Enriched GO Terms of Interacting Partners?		System Development Organ Development Multicellular Organismal Development Response To Stress Anatomical Structure Development Regulation Of Cell Death Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Response To Stimulus Rhythmic Process Cellular Metabolic Process Cellular Response To Stimulus Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Differentiation Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Nitrogen Compound Metabolic Process Circadian Rhythm Regulation Of DNA Binding Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Response To Stress Negative Regulation Of Cell Differentiation Apoptotic Process Negative Regulation Of DNA Binding Regulation Of Cell Differentiation Programmed Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Death Death Regulation Of Osteoblast Differentiation Positive Regulation Of Apoptotic Process DNA Repair Response To Growth Factor Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Negative Regulation Of Cell Death	Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Signaling Cell Communication Regulation Of Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Homodimerization Activity Regulation Of Intracellular Signal Transduction Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Cellular Response To Stimulus Positive Regulation Of Binding Lymph Node Development Regulation Of Endopeptidase Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Protein Homodimerization Activity Regulation Of Peptidase Activity Immune System Process Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Signaling Activation Of Innate Immune Response Regulation Of JNK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Stress-activated MAPK Cascade
Tagcloud ?		alterations anatomic astrocytoma astrocytomas biology braf grade hey1 hey2 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable	affymetrix agilent asct canvac cgvhd dnjgb1 dusp1 egwas fosb generalizable genomics geo identifier illumina justify manifestation merged mmp2 mutual omnibus players repository resembles sepx1 ssc standalone subtraction tnfaip8 uploaded
Tagcloud (Difference) ?		alterations anatomic astrocytoma astrocytomas biology braf grade hey1 hey2 implicated inhibiting interference much needed neoplastic notch notch1 notch2 overexpressed pa pas pediatric pilocytic res186 res259 secretase tumorigenesis variable viable	affymetrix agilent asct canvac cgvhd dnjgb1 dusp1 egwas fosb generalizable genomics geo identifier illumina justify manifestation merged mmp2 mutual omnibus players repository resembles sepx1 ssc standalone subtraction tnfaip8 uploaded
Tagcloud (Intersection) ?