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ABL1 and CDK5
Number of citations of the paper that reports this interaction (PubMedID
10896159
)
0
Data Source:
HPRD
(in vivo, in vitro)
ABL1
CDK5
Description
ABL proto-oncogene 1, non-receptor tyrosine kinase
cyclin dependent kinase 5
Image
GO Annotations
Cellular Component
Ruffle
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Cytoskeleton
Plasma Membrane
Postsynaptic Density
Actin Cytoskeleton
Membrane
Nuclear Body
Dendrite
Growth Cone
Cell Leading Edge
Nuclear Membrane
Protein-containing Complex
Neuronal Cell Body
Perinuclear Region Of Cytoplasm
Postsynapse
Glutamatergic Synapse
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule
Plasma Membrane
Postsynaptic Density
Membrane
Protein Kinase 5 Complex
Lamellipodium
Cell Junction
Filopodium
Axon
Dendrite
Growth Cone
Neuromuscular Junction
Cell Projection
Neuron Projection
Neuronal Cell Body
Perikaryon
Synapse
Presynapse
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
Bubble DNA Binding
Phosphotyrosine Residue Binding
DNA Binding
Transcription Coactivator Activity
Actin Monomer Binding
Nicotinate-nucleotide Adenylyltransferase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Enzyme Activator Activity
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Syntaxin Binding
Manganese Ion Binding
Neuropilin Binding
SH2 Domain Binding
Protein Serine/threonine Kinase Activator Activity
Metal Ion Binding
Ephrin Receptor Binding
Actin Filament Binding
Mitogen-activated Protein Kinase Binding
Proline-rich Region Binding
Delta-catenin Binding
Supercoiled DNA Binding
Sequence-specific Double-stranded DNA Binding
Nucleotide Binding
P53 Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
ErbB-2 Class Receptor Binding
Protein Binding
ATP Binding
Microtubule Binding
Kinase Activity
Transferase Activity
Signaling Receptor Inhibitor Activity
Acetylcholine Receptor Activator Activity
Ionotropic Glutamate Receptor Binding
ErbB-3 Class Receptor Binding
Tau Protein Binding
Tau-protein Kinase Activity
Hsp90 Protein Binding
Protein Serine Kinase Activity
Biological Process
Mitotic Cell Cycle
Neural Tube Closure
B-1 B Cell Homeostasis
Immune Effector Process
B Cell Proliferation Involved In Immune Response
Transitional One Stage B Cell Differentiation
Immune Response-activating Cell Surface Receptor Signaling Pathway
DNA Repair
Mismatch Repair
Regulation Of DNA-templated Transcription
Endocytosis
Phagocytosis
Autophagy
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Cell Adhesion
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Canonical NF-kappaB Signal Transduction
Learning Or Memory
Associative Learning
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Xenobiotic Stimulus
Post-embryonic Development
Regulation Of Gene Expression
Regulation Of Autophagy
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Endothelial Cell Migration
Cerebellum Morphogenesis
Negative Regulation Of Cell-cell Adhesion
Microspike Assembly
Actin Cytoskeleton Organization
Actin Filament Polymerization
Regulation Of Endocytosis
Regulation Of Cell Adhesion
Neuron Differentiation
BMP Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Regulation Of Axon Extension
Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway
Regulation Of Microtubule Polymerization
Regulation Of Cdc42 Protein Signal Transduction
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Cellular Response To Stress
Positive Regulation Of Osteoblast Proliferation
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Oxidative Stress
Response To Endoplasmic Reticulum Stress
Intracellular Signal Transduction
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Protein Modification Process
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Neuropilin Signaling Pathway
B Cell Proliferation
Regulation Of Cell Population Proliferation
Signal Transduction In Response To DNA Damage
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Endothelial Cell Migration
Regulation Of T Cell Differentiation
Regulation Of Cell Differentiation
Positive Regulation Of Cell Adhesion
Positive Regulation Of Vasoconstriction
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Alpha-beta T Cell Differentiation
Platelet-derived Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Spleen Development
Thymus Development
Activated T Cell Proliferation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Neuromuscular Process Controlling Balance
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Neuron Apoptotic Process
Negative Regulation Of Ubiquitin-protein Transferase Activity
Myoblast Proliferation
Positive Regulation Of Stress Fiber Assembly
Establishment Of Localization In Cell
Regulation Of Cell Cycle
Mitochondrial Depolarization
Positive Regulation Of Focal Adhesion Assembly
Bergmann Glial Cell Differentiation
Cardiac Muscle Cell Proliferation
Neuroepithelial Cell Differentiation
Cellular Response To Hydrogen Peroxide
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
DNA Conformation Change
Cellular Response To Lipopolysaccharide
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Epinephrine
Circulatory System Development
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Cellular Senescence
Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress
Cell-cell Adhesion
Regulation Of Postsynaptic Specialization Assembly
Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction
Positive Regulation Of Dendrite Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Long-term Synaptic Potentiation
Cellular Response To Oxygen-containing Compound
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of Intracellular Signal Transduction
Regulation Of Extracellular Matrix Organization
Positive Regulation Of Extracellular Matrix Organization
Podocyte Apoptotic Process
Cellular Response To Dopamine
Positive Regulation Of Establishment Of T Cell Polarity
DN4 Thymocyte Differentiation
Protein Localization To Cytoplasmic Microtubule Plus-end
Regulation Of Modification Of Synaptic Structure
Positive Regulation Of Blood Vessel Branching
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Cell Motility
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of T Cell Migration
Regulation Of Cellular Senescence
Negative Regulation Of Cellular Senescence
Microtubule Cytoskeleton Organization
Neuron Migration
Synaptic Transmission, Dopaminergic
Intracellular Protein Transport
Apoptotic Process
Cell-matrix Adhesion
Chemical Synaptic Transmission
Nervous System Development
Axonogenesis
Synapse Assembly
Skeletal Muscle Tissue Development
Motor Neuron Axon Guidance
Associative Learning
Visual Learning
Schwann Cell Development
Synaptic Vesicle Exocytosis
Regulation Of Macroautophagy
Cell Migration
Sensory Perception Of Pain
Telencephalon Development
Cerebellum Development
Cerebellar Cortex Development
Cerebellar Cortex Formation
Hippocampus Development
Layer Formation In Cerebral Cortex
Central Nervous System Neuron Development
Cerebral Cortex Development
Corpus Callosum Development
Actin Cytoskeleton Organization
Neuron Differentiation
Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Forebrain Development
Neuron Projection Development
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of Synaptic Plasticity
Receptor Catabolic Process
Synaptic Transmission, Glutamatergic
Protein Localization To Synapse
Response To Cocaine
Regulation Of Apoptotic Process
Receptor Clustering
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Proteolysis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Calcium Ion-dependent Exocytosis
Negative Regulation Of Protein Export From Nucleus
Behavioral Response To Cocaine
Regulation Of Synaptic Plasticity
Synaptic Vesicle Endocytosis
Synaptic Vesicle Transport
Rhythmic Process
Axon Extension
Oligodendrocyte Differentiation
Dendrite Morphogenesis
Cell Division
Neuron Apoptotic Process
Establishment Of Localization In Cell
Regulation Of Cell Cycle
Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Postsynaptic Membrane Potential
Excitatory Postsynaptic Potential
Regulation Of Dendritic Spine Morphogenesis
Calcium Ion Import
Positive Regulation Of Protein Targeting To Membrane
Positive Regulation Of Presynaptic Cytosolic Calcium Concentration
Regulation Of Cell Cycle Phase Transition
Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter
Regulation Of Synaptic Vesicle Recycling
Cellular Response To Amyloid-beta
Pathways
Regulation of actin dynamics for phagocytic cup formation
Role of ABL in ROBO-SLIT signaling
Role of ABL in ROBO-SLIT signaling
Myogenesis
Myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Cyclin D associated events in G1
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
DARPP-32 events
CRMPs in Sema3A signaling
CRMPs in Sema3A signaling
Regulation of TP53 Activity through Phosphorylation
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
NGF-stimulated transcription
Activated NTRK2 signals through CDK5
NPAS4 regulates expression of target genes
Factors involved in megakaryocyte development and platelet production
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs
ATP
Imatinib
Dasatinib
N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
Nilotinib
XL228
Bosutinib
2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
Myristic acid
PD-166326
5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
Regorafenib
Ponatinib
Fostamatinib
Brigatinib
Radotinib
Asciminib
Umbralisib
Indirubin-3'-monoxime
Olomoucine
Hymenialdisine
SU9516
Alvocidib
Alsterpaullone
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Trilaciclib
Diseases
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
Chronic myeloid leukemia (CML)
GWAS
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Lymphocyte count (
32888494
)
Platelet count (
32888494
)
Red cell distribution width (
32888494
)
Response to amphetamines (
22952603
)
White blood cell count (
32888494
)
Age at first sexual intercourse (
34211149
)
Eyebrow thickness (
26926045
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
32888494
)
Interacting Genes
167 interacting genes:
ABI1
ABI2
ABL2
ACTA1
ADAM15
ANAPC15
ANKRA2
APBB1
APP
AR
ARHGAP17
ATM
ATR
BCAR1
BCR
BIN1
BRCA1
BTK
C3
CABLES1
CABLES2
CASP9
CAT
CAV1
CBL
CCND2
CD19
CDK1
CDK5
CDKN1A
CDKN1B
CDON
CREB1
CRK
CRKL
CTNND2
DAPK1
DDB1
DDB2
DENND2B
DOK1
DOK2
DOK3
DVL2
EMD
ENAH
EP300
EPHA3
EPHB2
EPS15L1
ERBB2
ERBB3
ERBB4
EVL
FBXO7
FOSL1
GJA8
GPX1
GRB10
GRB2
GRIN2D
GTF2F1
HCK
HERC1
HIPK2
HUWE1
INPPL1
JAK1
JAK2
JUN
KIT
KRT31
LATS2
LRRK1
MAP4K1
MAP4K5
MAPT
MAVS
MBP
MDM2
MICAL1
MUC1
NCK1
NCOA3
NCSTN
NEDD4
NEDD4L
NEDD9
NFAT5
NFKBIA
NTRK1
PAG1
PAK2
PDE4D
PDGFRB
PHACTR4
PIK3R1
PLCG1
PLEKHA4
PLSCR1
POLR2A
PRDX1
PRKD1
PRKDC
PSTPIP1
PTPN1
PTPN12
PTPN18
PTPN6
PXN
RAD51
RAD51B
RAD52
RAD9A
RAN
RAPGEF1
RASA1
RB1
RFX1
RIN1
ROBO1
ROS1
RYBP
SFN
SH3BP1
SH3BP2
SHB
SHD
SHE
SLC9A2
SOCS3
SORBS1
SORBS2
SORBS3
SOS2
SPRR2A
SPTA1
SPTAN1
SRC
SRCIN1
SRPK2
STUB1
TERT
TMPO
TOPBP1
TP53
TP73
TRAF6
TUB
UBC
VAV1
WASF1
WASF2
WASL
WRNIP1
XPO1
XRCC6
YAP1
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZAP70
ZDHHC16
78 interacting genes:
AATK
ABL1
ACTN1
ALAS1
AMPH
APP
BAG6
CABLES1
CABLES2
CCND2
CCND3
CCNG1
CDC25A
CDC25B
CDC25C
CDC37
CDK16
CDK5R1
CDK5R2
CDK5RAP1
CDK5RAP2
CDKN1B
CHN1
CSNK1D
DAB1
DCX
DNM1
ERBB3
EZR
FSD1
FYN
FZR1
GAK
GRIN2A
GSK3B
H1-0
H1-1
H1-5
HTRA2
KIF26B
LMTK2
MAP2K1
MAPK10
MAPT
MAST1
MBP
MEF2A
MEOX2
MIR9-1HG
NDEL1
NEDD4
NEDD4L
NES
PAK1
PCNA
PIKFYVE
PIP5K1C
PPARG
PPP1R1B
PPP1R2
PSEN1
PTPN2
PURA
RB1
RNF32
RPL34
SET
SPDYA
SRC
STX1A
STXBP1
SYN1
SYNJ1
TLN1
TP53
TRIM59
WASF1
YBX3
Entrez ID
25
1020
HPRD ID
01809
00449
Ensembl ID
ENSG00000097007
ENSG00000164885
Uniprot IDs
P00519
Q59FK4
A0A090N7W4
A0A0S2Z355
Q00535
PDB IDs
1AB2
1AWO
1BBZ
1JU5
1OPL
1ZZP
2ABL
2E2B
2F4J
2FO0
2G1T
2G2F
2G2H
2G2I
2GQG
2HIW
2HYY
2HZ0
2HZ4
2HZI
2O88
2V7A
3CS9
3EG0
3EG1
3EG2
3EG3
3EGU
3K2M
3PYY
3QRI
3QRJ
3QRK
3T04
3UE4
3UYO
4J9B
4J9C
4J9D
4J9E
4J9F
4J9G
4J9H
4J9I
4JJB
4JJC
4JJD
4TWP
4WA9
4XEY
4YC8
4ZOG
5DC0
5DC4
5DC9
5HU9
5MO4
5NP2
5OAZ
6AMV
6AMW
6BL8
6NPE
6NPU
6NPV
6XR6
6XR7
6XRG
7CC2
7DT2
7N9G
7PVQ
7PVR
7PVS
7PVV
7PW2
7W7X
7W7Y
8H7F
8H7H
8I7S
8I7T
8I7Z
8SSN
1H4L
1UNG
1UNH
1UNL
3O0G
4AU8
7VDP
7VDQ
7VDR
7VDS
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Intracellular Signaling Cassette
Regulation Of Cell Communication
Regulation Of Signaling
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cytosol
Regulation Of Intracellular Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Cellular Component Organization
SH3 Domain Binding
Cytoplasm
Phosphotyrosine Residue Binding
Protein Phosphorylation
Regulation Of Programmed Cell Death
Positive Regulation Of Signal Transduction
Cellular Response To Oxygen-containing Compound
Developmental Process
Regulation Of Apoptotic Process
Phosphorylation
Protein-containing Complex
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cellular Response To Stress
Plasma Membrane
Enzyme Binding
Peptidyl-tyrosine Phosphorylation
Regulation Of Developmental Process
Regulation Of Protein Localization
Protein Tyrosine Kinase Activity
Regulation Of Actin Filament-based Process
Immune System Process
Protein Kinase Activity
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Projection Organization
Negative Regulation Of Apoptotic Process
Regulation Of Actin Cytoskeleton Organization
Cellular Response To Growth Factor Stimulus
Cellular Developmental Process
DNA Damage Response
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Negative Regulation Of Signal Transduction
Regulation Of Immune System Process
Regulation Of MAPK Cascade
Response To Stress
Regulation Of Cell Population Proliferation
Protein Kinase Binding
Cytosol
Regulation Of Protein Metabolic Process
Regulation Of Catalytic Activity
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Developmental Process
Regulation Of Protein Modification Process
Intracellular Signal Transduction
Mitotic Cell Cycle Phase Transition
Regulation Of Cellular Component Organization
Regulation Of Neuron Apoptotic Process
Cell Cycle Phase Transition
Regulation Of Protein Serine/threonine Kinase Activity
Organelle Organization
Perinuclear Region Of Cytoplasm
Regulation Of Protein Kinase Activity
Cytoplasm
Cyclin-dependent Protein Kinase Holoenzyme Complex
Neuron Apoptotic Process
Regulation Of Organelle Organization
Regulation Of Kinase Activity
Kinase Activity
Cell Projection Organization
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Phosphorus Metabolic Process
Protein Kinase Activity
Regulation Of Phosphorylation
Regulation Of Cell Projection Organization
Regulation Of Neuron Projection Development
Cellular Developmental Process
Regulation Of Apoptotic Process
Endocytosis
Layer Formation In Cerebral Cortex
Regulation Of Protein Phosphorylation
Organelle Localization
Positive Regulation Of Cellular Component Organization
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Protein Catabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Apoptotic Process
Cellular Response To Oxygen-containing Compound
Regulation Of Mitotic Cell Cycle
Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Organelle Organization
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle
Negative Regulation Of Programmed Cell Death
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