ABL1 and PAK2

Number of citations of the paper that reports this interaction (PMID 11121037)
14

Data Source:
HPRD (in vivo)

		ABL1	PAK2
Gene Name		ABL proto-oncogene 1, non-receptor tyrosine kinase	p21 protein (Cdc42/Rac)-activated kinase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Leading Edge Nuclear Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding DNA Binding Actin Monomer Binding Nicotinate-nucleotide Adenylyltransferase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding SH3 Domain Binding Syntaxin Binding Manganese Ion Binding Actin Filament Binding Mitogen-activated Protein Kinase Binding Proline-rich Region Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding
	Biological Process	B-1 B Cell Homeostasis B Cell Proliferation Involved In Immune Response Transitional One Stage B Cell Differentiation Mismatch Repair Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Autophagy Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Response To Oxidative Stress Cell Cycle Arrest Mitotic Nuclear Division Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Blood Coagulation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Autophagy Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Proliferation Substrate Adhesion-dependent Cell Spreading Cellular Response To Oxidative Stress Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Muscle Cell Differentiation Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Spleen Development Thymus Development Collateral Sprouting Positive Regulation Of Peptidyl-tyrosine Phosphorylation Activated T Cell Proliferation B Cell Receptor Signaling Pathway Neuromuscular Process Controlling Balance Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Mitochondrial Depolarization Bergmann Glial Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Serine/threonine Kinase Activity Actin Filament Branching Positive Regulation Of Interleukin-2 Secretion Negative Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Death Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Cellular Response To Dopamine Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Cellular Senescence Regulation Of Response To DNA Damage Stimulus	Mitotic Cell Cycle Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Axon Guidance Viral Process Phosphorylation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		Role of Abl in Robo-Slit signaling CDO in myogenesis Axon guidance Myogenesis Fcgamma receptor (FCGR) dependent phagocytosis Factors involved in megakaryocyte development and platelet production Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Regulation of PAK-2p34 activity by PS-GAP/RHG10 Costimulation by the CD28 family Axon guidance HIV Infection FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Nef and signal transduction Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability Programmed Cell Death EPH-Ephrin signaling Innate Immune System Generation of second messenger molecules Semaphorin interactions Apoptotic execution phase CD28 co-stimulation Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis CD28 dependent Vav1 pathway Stimulation of the cell death response by PAK-2p34 TCR signaling Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Regulation of Apoptosis Adaptive Immune System
Drugs		Adenosine triphosphate Imatinib Dasatinib N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide Nilotinib Bosutinib 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA MYRISTIC ACID 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide Regorafenib Ponatinib
Diseases
GWAS		Response to amphetamines ( 22952603)	Total ventricular volume ( 21116278)
Protein-Protein Interactions		145 interactors: ABI1 ABI2 ABL2 ACTA1 ADAM15 ANKRA2 APBB1 APP ARHGAP17 ATM ATR BCAR1 BCR BIN1 BRCA1 BTK C3 CABLES1 CABLES2 CASP9 CAT CAV1 CBL CCND2 CD19 CDK1 CDK5 CDKN1B CDON CREB1 CRK CRKL CTNND2 DDB1 DDB2 DOK1 DOK2 DOK3 EGFR ENAH EP300 EPHA3 EPHB2 ERBB2 ERBB3 ERBB4 EVL GPX1 GRB10 GRB2 GRIN2D GTF2F1 HCK HUWE1 INPPL1 JAK1 JAK2 JUN KIT LATS2 MAP4K1 MAP4K5 MAPT MAVS MBP MDM2 MICAL1 MUC1 NCK1 NCOA3 NCSTN NEDD4 NEDD4L NEDD9 NFKBIA NTRK1 PAG1 PAK2 PDE4D PIK3R1 PLCG1 PLSCR1 POLR2A PRDX1 PRKD1 PRKDC PSMA7 PSTPIP1 PTPN12 PTPN18 PTPN6 PXN RAD51 RAD52 RAD9A RAN RAPGEF1 RASA1 RB1 RFX1 RIN1 ROBO1 ROS1 RYBP SFN SH3BP1 SH3BP2 SHD SHE SLC9A2 SORBS1 SORBS2 SORBS3 SOS2 SPRR2A SPTA1 SPTAN1 SRC SRPK2 ST5 STUB1 TERT TOPBP1 TP53 TP73 TRAF6 TUB UBC VAV1 WASF1 WASF2 WASL WRNIP1 XPO1 XRCC6 YAP1 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZAP70 ZDHHC16	51 interactors: ABI1 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 HCK HIST1H4F LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NPHP1 PACSIN3 RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1
Entrez ID		25	5062
HPRD ID		01809	05428
Ensembl ID		ENSG00000097007	ENSG00000180370
Uniprot IDs		P00519 Q59FK4	A8K5M4 Q13177
PDB IDs		1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3PYY 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO	3PCS
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Response To Stimulus Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Signaling Cell Communication Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stress Immune Response-regulating Cell Surface Receptor Signaling Pathway Programmed Cell Death Innate Immune Response Cell Death Death Immune System Process Apoptotic Process Immune Response-regulating Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Regulation Of Cell Death Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Immune Response Cell Differentiation Response To Growth Factor Regulation Of Immune Response Cellular Response To Organic Substance Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Defense Response Regulation Of Cellular Component Organization Cell Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Process ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Locomotion Anatomical Structure Development Movement Of Cell Or Subcellular Component	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Component Organization Axon Guidance Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Locomotion Cytoskeleton Organization Chemotaxis Phagocytosis Axonogenesis Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway ERBB Signaling Pathway Axon Development Cellular Response To Peptide Hormone Stimulus Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Cellular Response To Peptide Cell Projection Organization Actin Filament-based Process Neuron Projection Morphogenesis Signal Transduction Signaling Response To Peptide Hormone Peptidyl-tyrosine Autophosphorylation Cell Communication Innate Immune Response Cellular Response To Organonitrogen Compound Cell Development Cellular Response To Growth Factor Stimulus Apoptotic Process Response To Peptide Intracellular Signal Transduction Actin Cytoskeleton Organization Cell Projection Morphogenesis Regulation Of Immune System Process Cellular Response To Organic Substance Response To Growth Factor Cell Part Morphogenesis Programmed Cell Death
Tagcloud ?		aba abi1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding	cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Difference) ?		aba abi1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding	cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Intersection) ?