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ABL1 and CDKN1B
Number of citations of the paper that reports this interaction (PubMedID
17254966
)
0
Data Source:
BioGRID
(enzymatic study)
HPRD
(in vitro, in vivo)
ABL1
CDKN1B
Description
ABL proto-oncogene 1, non-receptor tyrosine kinase
cyclin dependent kinase inhibitor 1B
Image
GO Annotations
Cellular Component
Ruffle
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Cytoskeleton
Plasma Membrane
Postsynaptic Density
Actin Cytoskeleton
Membrane
Nuclear Body
Dendrite
Growth Cone
Cell Leading Edge
Nuclear Membrane
Protein-containing Complex
Neuronal Cell Body
Perinuclear Region Of Cytoplasm
Postsynapse
Glutamatergic Synapse
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Centrosome
Cytosol
Cilium
Cul4A-RING E3 Ubiquitin Ligase Complex
Ciliary Basal Body
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
Bubble DNA Binding
Phosphotyrosine Residue Binding
DNA Binding
Transcription Coactivator Activity
Actin Monomer Binding
Nicotinate-nucleotide Adenylyltransferase Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Enzyme Activator Activity
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Syntaxin Binding
Manganese Ion Binding
Neuropilin Binding
SH2 Domain Binding
Protein Serine/threonine Kinase Activator Activity
Metal Ion Binding
Ephrin Receptor Binding
Actin Filament Binding
Mitogen-activated Protein Kinase Binding
Proline-rich Region Binding
Delta-catenin Binding
Supercoiled DNA Binding
Sequence-specific Double-stranded DNA Binding
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cyclin-dependent Protein Kinase Regulator Activity
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Protein-folding Chaperone Binding
Molecular Adaptor Activity
Molecular Function Inhibitor Activity
Ubiquitin Ligase Activator Activity
Biological Process
Mitotic Cell Cycle
Neural Tube Closure
B-1 B Cell Homeostasis
Immune Effector Process
B Cell Proliferation Involved In Immune Response
Transitional One Stage B Cell Differentiation
Immune Response-activating Cell Surface Receptor Signaling Pathway
DNA Repair
Mismatch Repair
Regulation Of DNA-templated Transcription
Endocytosis
Phagocytosis
Autophagy
Apoptotic Process
DNA Damage Response
Response To Oxidative Stress
Cell Adhesion
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Canonical NF-kappaB Signal Transduction
Learning Or Memory
Associative Learning
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Xenobiotic Stimulus
Post-embryonic Development
Regulation Of Gene Expression
Regulation Of Autophagy
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Endothelial Cell Migration
Cerebellum Morphogenesis
Negative Regulation Of Cell-cell Adhesion
Microspike Assembly
Actin Cytoskeleton Organization
Actin Filament Polymerization
Regulation Of Endocytosis
Regulation Of Cell Adhesion
Neuron Differentiation
BMP Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Regulation Of Axon Extension
Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway
Regulation Of Microtubule Polymerization
Regulation Of Cdc42 Protein Signal Transduction
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Cellular Response To Stress
Positive Regulation Of Osteoblast Proliferation
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Oxidative Stress
Response To Endoplasmic Reticulum Stress
Intracellular Signal Transduction
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Protein Modification Process
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Neuropilin Signaling Pathway
B Cell Proliferation
Regulation Of Cell Population Proliferation
Signal Transduction In Response To DNA Damage
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Endothelial Cell Migration
Regulation Of T Cell Differentiation
Regulation Of Cell Differentiation
Positive Regulation Of Cell Adhesion
Positive Regulation Of Vasoconstriction
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Alpha-beta T Cell Differentiation
Platelet-derived Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Spleen Development
Thymus Development
Activated T Cell Proliferation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Neuromuscular Process Controlling Balance
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Neuron Apoptotic Process
Negative Regulation Of Ubiquitin-protein Transferase Activity
Myoblast Proliferation
Positive Regulation Of Stress Fiber Assembly
Establishment Of Localization In Cell
Regulation Of Cell Cycle
Mitochondrial Depolarization
Positive Regulation Of Focal Adhesion Assembly
Bergmann Glial Cell Differentiation
Cardiac Muscle Cell Proliferation
Neuroepithelial Cell Differentiation
Cellular Response To Hydrogen Peroxide
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
DNA Conformation Change
Cellular Response To Lipopolysaccharide
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Epinephrine
Circulatory System Development
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Cellular Senescence
Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress
Cell-cell Adhesion
Regulation Of Postsynaptic Specialization Assembly
Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction
Positive Regulation Of Dendrite Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Long-term Synaptic Potentiation
Cellular Response To Oxygen-containing Compound
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of Intracellular Signal Transduction
Regulation Of Extracellular Matrix Organization
Positive Regulation Of Extracellular Matrix Organization
Podocyte Apoptotic Process
Cellular Response To Dopamine
Positive Regulation Of Establishment Of T Cell Polarity
DN4 Thymocyte Differentiation
Protein Localization To Cytoplasmic Microtubule Plus-end
Regulation Of Modification Of Synaptic Structure
Positive Regulation Of Blood Vessel Branching
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Cell Motility
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of T Cell Migration
Regulation Of Cellular Senescence
Negative Regulation Of Cellular Senescence
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Placenta Development
Potassium Ion Transport
Apoptotic Process
Regulation Of Exit From Mitosis
Notch Signaling Pathway
Regulation Of Mitotic Cell Cycle
Heart Development
Sensory Perception Of Sound
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Programmed Cell Death
Negative Regulation Of Cell Growth
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Cell Migration
Positive Regulation Of Microtubule Polymerization
Negative Regulation Of Kinase Activity
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of DNA Replication
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Growth
Negative Regulation Of Mitotic Cell Cycle
Autophagic Cell Death
Inner Ear Development
Negative Regulation Of Epithelial Cell Proliferation
Nuclear Export
Regulation Of Cell Cycle
Epithelial Cell Proliferation Involved In Prostate Gland Development
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Cellular Response To Antibiotic
Cellular Response To Lithium Ion
Cellular Senescence
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Lens Fiber Cell Differentiation
Regulation Of Cell Cycle G1/S Phase Transition
Epithelial Cell Apoptotic Process
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Regulation of actin dynamics for phagocytic cup formation
Role of ABL in ROBO-SLIT signaling
Role of ABL in ROBO-SLIT signaling
Myogenesis
Myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Cyclin D associated events in G1
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RHO GTPases activate CIT
Constitutive Signaling by AKT1 E17K in Cancer
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle
FLT3 Signaling
FOXO-mediated transcription of cell cycle genes
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
ATP
Imatinib
Dasatinib
N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
Nilotinib
XL228
Bosutinib
2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
Myristic acid
PD-166326
5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
Regorafenib
Ponatinib
Fostamatinib
Brigatinib
Radotinib
Asciminib
Umbralisib
Diseases
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
Chronic myeloid leukemia (CML)
Prostate cancer
GWAS
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Lymphocyte count (
32888494
)
Platelet count (
32888494
)
Red cell distribution width (
32888494
)
Response to amphetamines (
22952603
)
White blood cell count (
32888494
)
Appendicular lean mass (
33097823
)
Brain morphology (MOSTest) (
32665545
)
Diastolic blood pressure (
30487518
)
Mean arterial pressure (
29403010
30487518
)
Metabolite levels (
23823483
)
Monocyte percentage of white cells (
32888494
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Plateletcrit (
32888494
)
Prostate cancer (
29892016
31562322
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
23273568
33272962
)
Systolic blood pressure (
30487518
)
Type 2 diabetes (
30297969
)
Interacting Genes
167 interacting genes:
ABI1
ABI2
ABL2
ACTA1
ADAM15
ANAPC15
ANKRA2
APBB1
APP
AR
ARHGAP17
ATM
ATR
BCAR1
BCR
BIN1
BRCA1
BTK
C3
CABLES1
CABLES2
CASP9
CAT
CAV1
CBL
CCND2
CD19
CDK1
CDK5
CDKN1A
CDKN1B
CDON
CREB1
CRK
CRKL
CTNND2
DAPK1
DDB1
DDB2
DENND2B
DOK1
DOK2
DOK3
DVL2
EMD
ENAH
EP300
EPHA3
EPHB2
EPS15L1
ERBB2
ERBB3
ERBB4
EVL
FBXO7
FOSL1
GJA8
GPX1
GRB10
GRB2
GRIN2D
GTF2F1
HCK
HERC1
HIPK2
HUWE1
INPPL1
JAK1
JAK2
JUN
KIT
KRT31
LATS2
LRRK1
MAP4K1
MAP4K5
MAPT
MAVS
MBP
MDM2
MICAL1
MUC1
NCK1
NCOA3
NCSTN
NEDD4
NEDD4L
NEDD9
NFAT5
NFKBIA
NTRK1
PAG1
PAK2
PDE4D
PDGFRB
PHACTR4
PIK3R1
PLCG1
PLEKHA4
PLSCR1
POLR2A
PRDX1
PRKD1
PRKDC
PSTPIP1
PTPN1
PTPN12
PTPN18
PTPN6
PXN
RAD51
RAD51B
RAD52
RAD9A
RAN
RAPGEF1
RASA1
RB1
RFX1
RIN1
ROBO1
ROS1
RYBP
SFN
SH3BP1
SH3BP2
SHB
SHD
SHE
SLC9A2
SOCS3
SORBS1
SORBS2
SORBS3
SOS2
SPRR2A
SPTA1
SPTAN1
SRC
SRCIN1
SRPK2
STUB1
TERT
TMPO
TOPBP1
TP53
TP73
TRAF6
TUB
UBC
VAV1
WASF1
WASF2
WASL
WRNIP1
XPO1
XRCC6
YAP1
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZAP70
ZDHHC16
70 interacting genes:
ABL1
AKT1
ARHGDIA
ARIH1
CAMK1
CASP8
CCNA1
CCNA2
CCNB1
CCND1
CCND2
CCND3
CCNE2
CDC34
CDK2
CDK3
CDK4
CDK5
CKS1B
COP1
COPS5
CUL4A
DCLRE1C
GRB2
H1-1
H1-5
IRF1
KAT2B
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LYN
MAPK10
MCM7
MTUS2
MYC
NUP50
PIN1
PSMB1
RCHY1
RNF123
RNF6
RPS6KA1
SGK1
SIRT6
SKP1
SKP2
SPDYA
SRC
STMN1
TRAF2
TSC2
UBAC1
UBB
UBE2B
UBE2D2
UBE2L3
UBE3A
UCHL1
WWP1
XPO1
YES1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
25
1027
HPRD ID
01809
02867
Ensembl ID
ENSG00000097007
ENSG00000111276
Uniprot IDs
P00519
Q59FK4
P46527
Q6I9V6
PDB IDs
1AB2
1AWO
1BBZ
1JU5
1OPL
1ZZP
2ABL
2E2B
2F4J
2FO0
2G1T
2G2F
2G2H
2G2I
2GQG
2HIW
2HYY
2HZ0
2HZ4
2HZI
2O88
2V7A
3CS9
3EG0
3EG1
3EG2
3EG3
3EGU
3K2M
3PYY
3QRI
3QRJ
3QRK
3T04
3UE4
3UYO
4J9B
4J9C
4J9D
4J9E
4J9F
4J9G
4J9H
4J9I
4JJB
4JJC
4JJD
4TWP
4WA9
4XEY
4YC8
4ZOG
5DC0
5DC4
5DC9
5HU9
5MO4
5NP2
5OAZ
6AMV
6AMW
6BL8
6NPE
6NPU
6NPV
6XR6
6XR7
6XRG
7CC2
7DT2
7N9G
7PVQ
7PVR
7PVS
7PVV
7PW2
7W7X
7W7Y
8H7F
8H7H
8I7S
8I7T
8I7Z
8SSN
1H27
1JSU
2AST
5UQ3
6ATH
6P8E
6P8F
6P8G
7B5L
7B5M
7B5R
7OR8
7ORG
7ORH
7ORS
7ORT
8BYA
8BYL
8BZO
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Signal Transduction
Intracellular Signaling Cassette
Regulation Of Cell Communication
Regulation Of Signaling
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cytosol
Regulation Of Intracellular Signal Transduction
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Cellular Component Organization
SH3 Domain Binding
Cytoplasm
Phosphotyrosine Residue Binding
Protein Phosphorylation
Regulation Of Programmed Cell Death
Positive Regulation Of Signal Transduction
Cellular Response To Oxygen-containing Compound
Developmental Process
Regulation Of Apoptotic Process
Phosphorylation
Protein-containing Complex
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cellular Response To Stress
Plasma Membrane
Enzyme Binding
Peptidyl-tyrosine Phosphorylation
Regulation Of Developmental Process
Regulation Of Protein Localization
Protein Tyrosine Kinase Activity
Regulation Of Actin Filament-based Process
Immune System Process
Protein Kinase Activity
Negative Regulation Of Programmed Cell Death
Regulation Of Cell Projection Organization
Negative Regulation Of Apoptotic Process
Regulation Of Actin Cytoskeleton Organization
Cellular Response To Growth Factor Stimulus
Cellular Developmental Process
DNA Damage Response
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Negative Regulation Of Signal Transduction
Regulation Of Immune System Process
Regulation Of MAPK Cascade
Response To Stress
Regulation Of Cell Population Proliferation
Cell Cycle G1/S Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Protein Modification Process
Nucleus
Cell Cycle Phase Transition
Nucleoplasm
Modification-dependent Protein Catabolic Process
Mitotic Cell Cycle Phase Transition
Cytosol
Post-translational Protein Modification
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cytoplasm
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Metabolic Process
Macromolecule Catabolic Process
Cyclin-dependent Protein Kinase Holoenzyme Complex
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Regulation Of Cell Cycle
Proteolysis
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Protein Domain Specific Binding
Cellular Response To Stress
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Modification Process
Regulation Of Protein Metabolic Process
Intracellular Signal Transduction
Catabolic Process
Protein Polyubiquitination
Protein Localization To Nucleus
Transferase Activity
NLS-dependent Protein Nuclear Import Complex
Regulation Of Macromolecule Metabolic Process
Protein Catabolic Process
Regulation Of Metabolic Process
Ubiquitin-protein Transferase Activity
NLS-bearing Protein Import Into Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
Proteasomal Protein Catabolic Process
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Regulation Of DNA Metabolic Process
Protein Import Into Nucleus
Import Into Nucleus
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Mitotic Cell Cycle
Ubiquitin Protein Ligase Binding
Protein Kinase Binding
Phosphoserine Residue Binding
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Tagcloud (Intersection)
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