ABL1 and TP73

Number of citations of the paper that reports this interaction (PMID 10391251)
115

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		ABL1	TP73
Gene Name		ABL proto-oncogene 1, non-receptor tyrosine kinase	tumor protein p73
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Leading Edge Nuclear Membrane Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Factor Complex Golgi Apparatus Cytosol Cell Junction Intracellular Membrane-bounded Organelle
	Molecular Function	Magnesium Ion Binding DNA Binding Actin Monomer Binding Nicotinate-nucleotide Adenylyltransferase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding SH3 Domain Binding Syntaxin Binding Manganese Ion Binding Actin Filament Binding Mitogen-activated Protein Kinase Binding Proline-rich Region Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription P53 Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	B-1 B Cell Homeostasis B Cell Proliferation Involved In Immune Response Transitional One Stage B Cell Differentiation Mismatch Repair Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Autophagy Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Response To Oxidative Stress Cell Cycle Arrest Mitotic Nuclear Division Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Blood Coagulation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Autophagy Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Proliferation Substrate Adhesion-dependent Cell Spreading Cellular Response To Oxidative Stress Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Muscle Cell Differentiation Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Spleen Development Thymus Development Collateral Sprouting Positive Regulation Of Peptidyl-tyrosine Phosphorylation Activated T Cell Proliferation B Cell Receptor Signaling Pathway Neuromuscular Process Controlling Balance Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Mitochondrial Depolarization Bergmann Glial Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Serine/threonine Kinase Activity Actin Filament Branching Positive Regulation Of Interleukin-2 Secretion Negative Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Death Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Cellular Response To Dopamine Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Cellular Senescence Regulation Of Response To DNA Damage Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Kidney Development Release Of Cytochrome C From Mitochondria Mismatch Repair Transcription From RNA Polymerase II Promoter Inflammatory Response Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Post-embryonic Development Response To X-ray Response To Organonitrogen Compound Response To Gamma Radiation Regulation Of Gene Expression Hippocampus Development Mitotic G1 DNA Damage Checkpoint Cerebrospinal Fluid Secretion Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of JUN Kinase Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Neuron Development Positive Regulation Of Oligodendrocyte Differentiation Protein Tetramerization Negative Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		Role of Abl in Robo-Slit signaling CDO in myogenesis Axon guidance Myogenesis Fcgamma receptor (FCGR) dependent phagocytosis Factors involved in megakaryocyte development and platelet production Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs		Adenosine triphosphate Imatinib Dasatinib N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide Nilotinib Bosutinib 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA MYRISTIC ACID 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide Regorafenib Ponatinib
Diseases
GWAS		Response to amphetamines ( 22952603)	Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Visceral fat ( 22589738)
Protein-Protein Interactions		145 interactors: ABI1 ABI2 ABL2 ACTA1 ADAM15 ANKRA2 APBB1 APP ARHGAP17 ATM ATR BCAR1 BCR BIN1 BRCA1 BTK C3 CABLES1 CABLES2 CASP9 CAT CAV1 CBL CCND2 CD19 CDK1 CDK5 CDKN1B CDON CREB1 CRK CRKL CTNND2 DDB1 DDB2 DOK1 DOK2 DOK3 EGFR ENAH EP300 EPHA3 EPHB2 ERBB2 ERBB3 ERBB4 EVL GPX1 GRB10 GRB2 GRIN2D GTF2F1 HCK HUWE1 INPPL1 JAK1 JAK2 JUN KIT LATS2 MAP4K1 MAP4K5 MAPT MAVS MBP MDM2 MICAL1 MUC1 NCK1 NCOA3 NCSTN NEDD4 NEDD4L NEDD9 NFKBIA NTRK1 PAG1 PAK2 PDE4D PIK3R1 PLCG1 PLSCR1 POLR2A PRDX1 PRKD1 PRKDC PSMA7 PSTPIP1 PTPN12 PTPN18 PTPN6 PXN RAD51 RAD52 RAD9A RAN RAPGEF1 RASA1 RB1 RFX1 RIN1 ROBO1 ROS1 RYBP SFN SH3BP1 SH3BP2 SHD SHE SLC9A2 SORBS1 SORBS2 SORBS3 SOS2 SPRR2A SPTA1 SPTAN1 SRC SRPK2 ST5 STUB1 TERT TOPBP1 TP53 TP73 TRAF6 TUB UBC VAV1 WASF1 WASF2 WASL WRNIP1 XPO1 XRCC6 YAP1 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZAP70 ZDHHC16	50 interactors: ABL1 AURKA BIN1 BUB1B CABLES1 CCNB1 CCND1 CCNE1 CDK1 CDK2 CEBPZ CHD3 CREBBP DAXX EP300 FBXO45 GNB2L1 HECW2 HIPK2 HIPK3 HMGB1 HRAS IKBKB ITCH KAT2B MAPK8 MDM2 MDM4 MYC NEDD4 NFYB PFDN5 PIAS1 PIN1 PML PPP1R13B RANBP9 RBX1 RCHY1 SMAD2 SMAD3 SUMO1 TDG TP53 TP63 UBE2I WT1 WWOX XPO1 YAP1
Entrez ID		25	7161
HPRD ID		01809	03587
Ensembl ID		ENSG00000097007	ENSG00000078900
Uniprot IDs		P00519 Q59FK4	C9J521 O15350
PDB IDs		1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3PYY 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO	1COK 1DXS 2KBY 2WQI 2WQJ 2WTT 2XWC 3VD0 3VD1 3VD2 4A63 4G82 4G83 4GUQ
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Response To Stimulus Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Signaling Cell Communication Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stress Immune Response-regulating Cell Surface Receptor Signaling Pathway Programmed Cell Death Innate Immune Response Cell Death Death Immune System Process Apoptotic Process Immune Response-regulating Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Regulation Of Cell Death Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Immune Response Cell Differentiation Response To Growth Factor Regulation Of Immune Response Cellular Response To Organic Substance Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Defense Response Regulation Of Cellular Component Organization Cell Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Process ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Locomotion Anatomical Structure Development Movement Of Cell Or Subcellular Component	Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Protein Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Apoptotic Process Programmed Cell Death Negative Regulation Of Cell Cycle Cell Cycle Process Regulation Of Signal Transduction Cell Death Cellular Response To Stress Death Positive Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To DNA Damage Stimulus Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Response To Stress Mitotic Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Proteolysis Negative Regulation Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		aba abi1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding	acidic amylin calcitonin calcr causally deltan glycolysis iapp implement interplay isoforms lymphomas manipulating p63 pramlintide ramp3 reactivation reprogramming resemble suppressive ta tap63 tap73 therapeutically thymic tp53 tp63 tumours
Tagcloud (Difference) ?		aba abi1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding	acidic amylin calcitonin calcr causally deltan glycolysis iapp implement interplay isoforms lymphomas manipulating p63 pramlintide ramp3 reactivation reprogramming resemble suppressive ta tap63 tap73 therapeutically thymic tp53 tp63 tumours
Tagcloud (Intersection) ?