ABL1 and HERC1

Number of citations of the paper that reports this interaction (PubMedID 33477751)
44

Data Source:
BioGRID (enzymatic study)

		ABL1	HERC1
Description		ABL proto-oncogene 1, non-receptor tyrosine kinase	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
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GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Actin Cytoskeleton Membrane Nuclear Body Dendrite Growth Cone Cell Leading Edge Nuclear Membrane Protein-containing Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm Postsynapse Glutamatergic Synapse	Cytoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Four-way Junction DNA Binding Bubble DNA Binding Phosphotyrosine Residue Binding DNA Binding Transcription Coactivator Activity Actin Monomer Binding Nicotinate-nucleotide Adenylyltransferase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Enzyme Activator Activity Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Manganese Ion Binding Neuropilin Binding SH2 Domain Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Ephrin Receptor Binding Actin Filament Binding Mitogen-activated Protein Kinase Binding Proline-rich Region Binding Delta-catenin Binding Supercoiled DNA Binding Sequence-specific Double-stranded DNA Binding	Ubiquitin-protein Transferase Activity Guanyl-nucleotide Exchange Factor Activity Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Mitotic Cell Cycle Neural Tube Closure B-1 B Cell Homeostasis Immune Effector Process B Cell Proliferation Involved In Immune Response Transitional One Stage B Cell Differentiation Immune Response-activating Cell Surface Receptor Signaling Pathway DNA Repair Mismatch Repair Regulation Of DNA-templated Transcription Endocytosis Phagocytosis Autophagy Apoptotic Process DNA Damage Response Response To Oxidative Stress Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Learning Or Memory Associative Learning Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Post-embryonic Development Regulation Of Gene Expression Regulation Of Autophagy Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Endothelial Cell Migration Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Endocytosis Regulation Of Cell Adhesion Neuron Differentiation BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Regulation Of Axon Extension Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Microtubule Polymerization Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Regulation Of Actin Cytoskeleton Organization Cellular Response To Stress Positive Regulation Of Osteoblast Proliferation Substrate Adhesion-dependent Cell Spreading Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Platelet-derived Growth Factor Receptor-beta Signaling Pathway Protein Modification Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neuropilin Signaling Pathway B Cell Proliferation Regulation Of Cell Population Proliferation Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Regulation Of T Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Vasoconstriction Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Spleen Development Thymus Development Activated T Cell Proliferation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Neuromuscular Process Controlling Balance Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Myoblast Proliferation Positive Regulation Of Stress Fiber Assembly Establishment Of Localization In Cell Regulation Of Cell Cycle Mitochondrial Depolarization Positive Regulation Of Focal Adhesion Assembly Bergmann Glial Cell Differentiation Cardiac Muscle Cell Proliferation Neuroepithelial Cell Differentiation Cellular Response To Hydrogen Peroxide ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade DNA Conformation Change Cellular Response To Lipopolysaccharide Cellular Response To Transforming Growth Factor Beta Stimulus Response To Epinephrine Circulatory System Development Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cellular Senescence Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Cell-cell Adhesion Regulation Of Postsynaptic Specialization Assembly Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Dendrite Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Long-term Synaptic Potentiation Cellular Response To Oxygen-containing Compound Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Extracellular Matrix Organization Positive Regulation Of Extracellular Matrix Organization Podocyte Apoptotic Process Cellular Response To Dopamine Positive Regulation Of Establishment Of T Cell Polarity DN4 Thymocyte Differentiation Protein Localization To Cytoplasmic Microtubule Plus-end Regulation Of Modification Of Synaptic Structure Positive Regulation Of Blood Vessel Branching Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration Regulation Of Cellular Senescence Negative Regulation Of Cellular Senescence	Autophagy Brain Development Gene Expression Negative Regulation Of Autophagy Protein Ubiquitination Cerebellar Purkinje Cell Differentiation Corpus Callosum Development Bone Mineralization Neuron Projection Development Bone Remodeling Neuromuscular Process Controlling Balance
Pathways		Regulation of actin dynamics for phagocytic cup formation Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling Myogenesis Myogenesis RHO GTPases Activate WASPs and WAVEs HDR through Single Strand Annealing (SSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Cyclin D associated events in G1 RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		ATP Imatinib Dasatinib N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide Nilotinib XL228 Bosutinib 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA Myristic acid PD-166326 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide Regorafenib Ponatinib Fostamatinib Brigatinib Radotinib Asciminib Umbralisib
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Chronic myeloid leukemia (CML)
GWAS		Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Lymphocyte count ( 32888494) Platelet count ( 32888494) Red cell distribution width ( 32888494) Response to amphetamines ( 22952603) White blood cell count ( 32888494)	A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Glucagon levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Iris characteristics ( 21835309) Reticulocyte fraction of red cells ( 27863252) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		167 interacting genes: ABI1 ABI2 ABL2 ACTA1 ADAM15 ANAPC15 ANKRA2 APBB1 APP AR ARHGAP17 ATM ATR BCAR1 BCR BIN1 BRCA1 BTK C3 CABLES1 CABLES2 CASP9 CAT CAV1 CBL CCND2 CD19 CDK1 CDK5 CDKN1A CDKN1B CDON CREB1 CRK CRKL CTNND2 DAPK1 DDB1 DDB2 DENND2B DOK1 DOK2 DOK3 DVL2 EMD ENAH EP300 EPHA3 EPHB2 EPS15L1 ERBB2 ERBB3 ERBB4 EVL FBXO7 FOSL1 GJA8 GPX1 GRB10 GRB2 GRIN2D GTF2F1 HCK HERC1 HIPK2 HUWE1 INPPL1 JAK1 JAK2 JUN KIT KRT31 LATS2 LRRK1 MAP4K1 MAP4K5 MAPT MAVS MBP MDM2 MICAL1 MUC1 NCK1 NCOA3 NCSTN NEDD4 NEDD4L NEDD9 NFAT5 NFKBIA NTRK1 PAG1 PAK2 PDE4D PDGFRB PHACTR4 PIK3R1 PLCG1 PLEKHA4 PLSCR1 POLR2A PRDX1 PRKD1 PRKDC PSTPIP1 PTPN1 PTPN12 PTPN18 PTPN6 PXN RAD51 RAD51B RAD52 RAD9A RAN RAPGEF1 RASA1 RB1 RFX1 RIN1 ROBO1 ROS1 RYBP SFN SH3BP1 SH3BP2 SHB SHD SHE SLC9A2 SOCS3 SORBS1 SORBS2 SORBS3 SOS2 SPRR2A SPTA1 SPTAN1 SRC SRCIN1 SRPK2 STUB1 TERT TMPO TOPBP1 TP53 TP73 TRAF6 TUB UBC VAV1 WASF1 WASF2 WASL WRNIP1 XPO1 XRCC6 YAP1 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZAP70 ZDHHC16	15 interacting genes: ABL1 BAK1 EP300 FOXP1 LAPTM5 PKM RAF1 RNF11 SOX9 UBC UBE2D2 UBE2D3 UBE2L3 UBE2S USP7
Entrez ID		25	8925
HPRD ID		01809	06894
Ensembl ID		ENSG00000097007	ENSG00000103657
Uniprot IDs		P00519 Q59FK4	Q15751
PDB IDs		1AB2 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3PYY 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO 4J9B 4J9C 4J9D 4J9E 4J9F 4J9G 4J9H 4J9I 4JJB 4JJC 4JJD 4TWP 4WA9 4XEY 4YC8 4ZOG 5DC0 5DC4 5DC9 5HU9 5MO4 5NP2 5OAZ 6AMV 6AMW 6BL8 6NPE 6NPU 6NPV 6XR6 6XR7 6XRG 7CC2 7DT2 7N9G 7PVQ 7PVR 7PVS 7PVV 7PW2 7W7X 7W7Y 8H7F 8H7H 8I7S 8I7T 8I7Z 8SSN	4O2W 4QT6
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytosol Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization SH3 Domain Binding Cytoplasm Phosphotyrosine Residue Binding Protein Phosphorylation Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Developmental Process Regulation Of Apoptotic Process Phosphorylation Protein-containing Complex Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Response To Stress Plasma Membrane Enzyme Binding Peptidyl-tyrosine Phosphorylation Regulation Of Developmental Process Regulation Of Protein Localization Protein Tyrosine Kinase Activity Regulation Of Actin Filament-based Process Immune System Process Protein Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Cell Projection Organization Negative Regulation Of Apoptotic Process Regulation Of Actin Cytoskeleton Organization Cellular Response To Growth Factor Stimulus Cellular Developmental Process DNA Damage Response Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of MAPK Cascade Response To Stress Regulation Of Cell Population Proliferation	Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Metabolic Process Protein Modification Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Programmed Cell Death Cell Death Apoptotic Signaling Pathway Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Negative Regulation Of Signal Transduction Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Cell Communication Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein-containing Complex Assembly Protein Metabolic Process Regulation Of Morphogenesis Of An Epithelium Protein-containing Complex Proteolysis Protein Autoubiquitination DNA Damage Response Transferase Activity ERBB Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Pre-mRNA Intronic Binding Regulation Of Primary Metabolic Process Ubiquitin-protein Transferase Activity Apoptotic Process Negative Regulation Of Programmed Cell Death ATP Binding Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Transcription Coactivator Activity Endocrine Pancreas Development Positive Regulation Of Protein Ubiquitination Nucleus Negative Regulation Of Gluconeogenesis Ubiquitin-like Protein Transferase Activity Negative Regulation Of Small Molecule Metabolic Process Cytosol Macromolecule Catabolic Process
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