ABL1 and GPX1

Number of citations of the paper that reports this interaction (PMID 12893824)
20

Data Source:
BioGRID (pull down, pull down, two hybrid, enzymatic study)
HPRD (in vitro, in vivo, two hybrid)

		ABL1	GPX1
Gene Name		ABL proto-oncogene 1, non-receptor tyrosine kinase	glutathione peroxidase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Leading Edge Nuclear Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Extracellular Vesicular Exosome Lewy Body
	Molecular Function	Magnesium Ion Binding DNA Binding Actin Monomer Binding Nicotinate-nucleotide Adenylyltransferase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding SH3 Domain Binding Syntaxin Binding Manganese Ion Binding Actin Filament Binding Mitogen-activated Protein Kinase Binding Proline-rich Region Binding	Glutathione Peroxidase Activity Selenium Binding SH3 Domain Binding Glutathione Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	B-1 B Cell Homeostasis B Cell Proliferation Involved In Immune Response Transitional One Stage B Cell Differentiation Mismatch Repair Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Autophagy Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Response To Oxidative Stress Cell Cycle Arrest Mitotic Nuclear Division Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Blood Coagulation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Autophagy Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Proliferation Substrate Adhesion-dependent Cell Spreading Cellular Response To Oxidative Stress Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Muscle Cell Differentiation Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Spleen Development Thymus Development Collateral Sprouting Positive Regulation Of Peptidyl-tyrosine Phosphorylation Activated T Cell Proliferation B Cell Receptor Signaling Pathway Neuromuscular Process Controlling Balance Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Mitochondrial Depolarization Bergmann Glial Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Serine/threonine Kinase Activity Actin Filament Branching Positive Regulation Of Interleukin-2 Secretion Negative Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Death Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Cellular Response To Dopamine Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Cellular Senescence Regulation Of Response To DNA Damage Stimulus	Response To Reactive Oxygen Species Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Purine Nucleobase Metabolic Process Purine Nucleotide Catabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Response To Lipid Hydroperoxide Aging Sensory Perception Of Sound Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Symbiotic Bacterium Response To Toxic Substance UV Protection Response To Glucose Response To Selenium Ion Response To Gamma Radiation Protein Oxidation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Estradiol Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Response To Nicotine Regulation Of Gene Expression, Epigenetic Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Fat Cell Differentiation Cell Redox Homeostasis Skeletal Muscle Fiber Development Myoblast Proliferation Response To Folic Acid Interaction With Symbiont Positive Regulation Of Protein Kinase B Signaling Nucleobase-containing Small Molecule Metabolic Process Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Fibril Organization
Pathways		Role of Abl in Robo-Slit signaling CDO in myogenesis Axon guidance Myogenesis Fcgamma receptor (FCGR) dependent phagocytosis Factors involved in megakaryocyte development and platelet production Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Arachidonic acid metabolism Purine catabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Purine metabolism Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Metabolism of nucleotides
Drugs		Adenosine triphosphate Imatinib Dasatinib N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide Nilotinib Bosutinib 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA MYRISTIC ACID 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide Regorafenib Ponatinib	Glutathione
Diseases
GWAS		Response to amphetamines ( 22952603)	Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		145 interactors: ABI1 ABI2 ABL2 ACTA1 ADAM15 ANKRA2 APBB1 APP ARHGAP17 ATM ATR BCAR1 BCR BIN1 BRCA1 BTK C3 CABLES1 CABLES2 CASP9 CAT CAV1 CBL CCND2 CD19 CDK1 CDK5 CDKN1B CDON CREB1 CRK CRKL CTNND2 DDB1 DDB2 DOK1 DOK2 DOK3 EGFR ENAH EP300 EPHA3 EPHB2 ERBB2 ERBB3 ERBB4 EVL GPX1 GRB10 GRB2 GRIN2D GTF2F1 HCK HUWE1 INPPL1 JAK1 JAK2 JUN KIT LATS2 MAP4K1 MAP4K5 MAPT MAVS MBP MDM2 MICAL1 MUC1 NCK1 NCOA3 NCSTN NEDD4 NEDD4L NEDD9 NFKBIA NTRK1 PAG1 PAK2 PDE4D PIK3R1 PLCG1 PLSCR1 POLR2A PRDX1 PRKD1 PRKDC PSMA7 PSTPIP1 PTPN12 PTPN18 PTPN6 PXN RAD51 RAD52 RAD9A RAN RAPGEF1 RASA1 RB1 RFX1 RIN1 ROBO1 ROS1 RYBP SFN SH3BP1 SH3BP2 SHD SHE SLC9A2 SORBS1 SORBS2 SORBS3 SOS2 SPRR2A SPTA1 SPTAN1 SRC SRPK2 ST5 STUB1 TERT TOPBP1 TP53 TP73 TRAF6 TUB UBC VAV1 WASF1 WASF2 WASL WRNIP1 XPO1 XRCC6 YAP1 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZAP70 ZDHHC16	5 interactors: ABL1 ABL2 FAM9B MAPK6 SELENBP1
Entrez ID		25	2876
HPRD ID		01809	11749
Ensembl ID		ENSG00000097007	ENSG00000233276
Uniprot IDs		P00519 Q59FK4	P07203 Q7L4Q3
PDB IDs		1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3PYY 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO	2F8A
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Response To Stimulus Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Signaling Cell Communication Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stress Immune Response-regulating Cell Surface Receptor Signaling Pathway Programmed Cell Death Innate Immune Response Cell Death Death Immune System Process Apoptotic Process Immune Response-regulating Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Regulation Of Cell Death Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Immune Response Cell Differentiation Response To Growth Factor Regulation Of Immune Response Cellular Response To Organic Substance Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Defense Response Regulation Of Cellular Component Organization Cell Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Process ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Locomotion Anatomical Structure Development Movement Of Cell Or Subcellular Component	Positive Regulation Of Interferon-gamma Secretion Bergmann Glial Cell Differentiation Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Interleukin-2 Production Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Oxidoreductase Activity Regulation Of Actin Cytoskeleton Reorganization Regulation Of Extracellular Matrix Organization Astrocyte Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Cerebellum Morphogenesis Positive Regulation Of Interferon-gamma Production Hindbrain Morphogenesis Alpha-beta T Cell Differentiation Alpha-beta T Cell Activation Regulation Of Oxidoreductase Activity Neuromuscular Process Controlling Balance Regulation Of Phospholipase Activity Regulation Of Interferon-gamma Production Positive Regulation Of Cytokine Secretion Regulation Of Autophagy Cerebellum Development Transitional One Stage B Cell Differentiation Metencephalon Development Positive Regulation Of ERK1 And ERK2 Cascade Neuromuscular Process Regulation Of Cytokine Secretion Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Wnt Signaling Pathway T Cell Differentiation Positive Regulation Of Cytosolic Calcium Ion Concentration Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Hindbrain Development Negative Regulation Of Phospholipase C Activity Mitochondrial Depolarization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cytosolic Calcium Ion Homeostasis Glial Cell Differentiation Regulation Of Endocytosis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Secretion Negative Regulation Of Cell Adhesion Protein Autophosphorylation Cellular Response To Dopamine
Tagcloud ?		aba abi1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding	adequately antifouling aquatic carp carpio chronically contaminants cyprinus fishes glutathione gr gsh gst gstp1 indicators juvenile lethal malondialdehyde organotin paints peroxidase pollutants recognised reductase ships tbt transferase tributyltin
Tagcloud (Difference) ?		aba abi1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding	adequately antifouling aquatic carp carpio chronically contaminants cyprinus fishes glutathione gr gsh gst gstp1 indicators juvenile lethal malondialdehyde organotin paints peroxidase pollutants recognised reductase ships tbt transferase tributyltin
Tagcloud (Intersection) ?