ABL1 and DDB2

Number of citations: 55 (PubMedID 12107171)
Data Source: HPRD (in vivo)

		ABL1	DDB2
Name		ABL proto-oncogene 1, non-receptor tyrosine kinase	damage specific DNA binding protein 2
Structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Actin Cytoskeleton Membrane Nuclear Body Dendrite Growth Cone Cell Leading Edge Nuclear Membrane Protein-containing Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm Postsynapse Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Chromosome Cell Junction Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Cul4-RING E3 Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Four-way Junction DNA Binding Bubble DNA Binding Phosphotyrosine Residue Binding DNA Binding Transcription Coactivator Activity Actin Monomer Binding Nicotinate-nucleotide Adenylyltransferase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Enzyme Activator Activity Kinase Activity Transferase Activity Enzyme Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Manganese Ion Binding Neuropilin Binding SH2 Domain Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Ephrin Receptor Binding Actin Filament Binding Mitogen-activated Protein Kinase Binding Proline-rich Region Binding Delta-catenin Binding Supercoiled DNA Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Damaged DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Protein-containing Complex Binding
	Biological Process	Mitotic Cell Cycle Neural Tube Closure B-1 B Cell Homeostasis Immune Effector Process B Cell Proliferation Involved In Immune Response Transitional One Stage B Cell Differentiation Immune Response-activating Cell Surface Receptor Signaling Pathway DNA Repair Mismatch Repair Regulation Of DNA-templated Transcription Endocytosis Phagocytosis Autophagy Apoptotic Process DNA Damage Response Response To Oxidative Stress Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Learning Or Memory Associative Learning Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Xenobiotic Stimulus Post-embryonic Development Regulation Of Gene Expression Regulation Of Autophagy Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Endothelial Cell Migration Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Endocytosis Regulation Of Cell Adhesion Neuron Differentiation BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Regulation Of Axon Extension Phospholipase C-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Microtubule Polymerization Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Regulation Of Actin Cytoskeleton Organization Cellular Response To Stress Positive Regulation Of Osteoblast Proliferation Substrate Adhesion-dependent Cell Spreading Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Platelet-derived Growth Factor Receptor-beta Signaling Pathway Protein Modification Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neuropilin Signaling Pathway B Cell Proliferation Regulation Of Cell Population Proliferation Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Endothelial Cell Migration Regulation Of T Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Vasoconstriction Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Spleen Development Thymus Development Activated T Cell Proliferation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Neuromuscular Process Controlling Balance Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neuron Apoptotic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Myoblast Proliferation Positive Regulation Of Stress Fiber Assembly Establishment Of Localization In Cell Regulation Of Cell Cycle Mitochondrial Depolarization Positive Regulation Of Focal Adhesion Assembly Bergmann Glial Cell Differentiation Cardiac Muscle Cell Proliferation Neuroepithelial Cell Differentiation Cellular Response To Hydrogen Peroxide ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade DNA Conformation Change Cellular Response To Lipopolysaccharide Cellular Response To Transforming Growth Factor Beta Stimulus Response To Epinephrine Circulatory System Development Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cellular Senescence Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Cell-cell Adhesion Regulation Of Postsynaptic Specialization Assembly Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Dendrite Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Long-term Synaptic Potentiation Cellular Response To Oxygen-containing Compound Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Extracellular Matrix Organization Positive Regulation Of Extracellular Matrix Organization Podocyte Apoptotic Process Cellular Response To Dopamine Positive Regulation Of Establishment Of T Cell Polarity DN4 Thymocyte Differentiation Protein Localization To Cytoplasmic Microtubule Plus-end Regulation Of Modification Of Synaptic Structure Positive Regulation Of Blood Vessel Branching Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration Regulation Of Cellular Senescence Negative Regulation Of Cellular Senescence	Protein Polyubiquitination DNA Repair Nucleotide-excision Repair Pyrimidine Dimer Repair DNA Damage Response Response To UV Protein Ubiquitination Cellular Response To UV Protein Autoubiquitination UV-damage Excision Repair
Pathways		Regulation of actin dynamics for phagocytic cup formation Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling Myogenesis Myogenesis RHO GTPases Activate WASPs and WAVEs HDR through Single Strand Annealing (SSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Cyclin D associated events in G1 RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Ub-specific processing proteases DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER TP53 Regulates Transcription of DNA Repair Genes Neddylation
Drugs		ATP Imatinib Dasatinib N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide Nilotinib XL228 Bosutinib 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA Myristic acid PD-166326 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide Regorafenib Ponatinib Fostamatinib Brigatinib Radotinib Asciminib Umbralisib	None
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Chronic myeloid leukemia (CML)	Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444 ) Lymphocyte count ( 32888494 ) Platelet count ( 32888494 ) Red cell distribution width ( 32888494 ) Response to amphetamines ( 22952603 ) White blood cell count ( 32888494 )	Acne (severe) ( 24399259 ) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Feeling lonely ( 29500382 ) Feeling miserable ( 29500382 ) High density lipoprotein cholesterol levels ( 33339817 ) Lymphocyte percentage of white cells ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Neurociticism ( 29500382 ) Neuroticism ( 29255261 ) Refractive error ( 32231278 ) Triglyceride levels ( 32203549 )
Interacting Genes		167 interacting genes: ABI1 ABI2 ABL2 ACTA1 ADAM15 ANAPC15 ANKRA2 APBB1 APP AR ARHGAP17 ATM ATR BCAR1 BCR BIN1 BRCA1 BTK C3 CABLES1 CABLES2 CASP9 CAT CAV1 CBL CCND2 CD19 CDK1 CDK5 CDKN1A CDKN1B CDON CREB1 CRK CRKL CTNND2 DAPK1 DDB1 DDB2 DENND2B DOK1 DOK2 DOK3 DVL2 EMD ENAH EP300 EPHA3 EPHB2 EPS15L1 ERBB2 ERBB3 ERBB4 EVL FBXO7 FOSL1 GJA8 GPX1 GRB10 GRB2 GRIN2D GTF2F1 HCK HERC1 HIPK2 HUWE1 INPPL1 JAK1 JAK2 JUN KIT KRT31 LATS2 LRRK1 MAP4K1 MAP4K5 MAPT MAVS MBP MDM2 MICAL1 MUC1 NCK1 NCOA3 NCSTN NEDD4 NEDD4L NEDD9 NFAT5 NFKBIA NTRK1 PAG1 PAK2 PDE4D PDGFRB PHACTR4 PIK3R1 PLCG1 PLEKHA4 PLSCR1 POLR2A PRDX1 PRKD1 PRKDC PSTPIP1 PTPN1 PTPN12 PTPN18 PTPN6 PXN RAD51 RAD51B RAD52 RAD9A RAN RAPGEF1 RASA1 RB1 RFX1 RIN1 ROBO1 ROS1 RYBP SFN SH3BP1 SH3BP2 SHB SHD SHE SLC9A2 SOCS3 SORBS1 SORBS2 SORBS3 SOS2 SPRR2A SPTA1 SPTAN1 SRC SRCIN1 SRPK2 STUB1 TERT TMPO TOPBP1 TP53 TP73 TRAF6 TUB UBC VAV1 WASF1 WASF2 WASL WRNIP1 XPO1 XRCC6 YAP1 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZAP70 ZDHHC16	19 interacting genes: ABL1 AR CUL4A CUL4B DCLRE1C DDB1 E2F1 H2AC20 H3C14 HDAC1 NR5A2 NTMT1 RAD51 SIRT6 TOP1 USP24 USP40 XPA XPC
Entrez ID		25	1643
HPRD ID		01809	02886
Ensembl ID		ENSG00000097007	ENSG00000134574
Uniprot IDs		P00519 Q59FK4	Q92466
PDB IDs		1AB2 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3PYY 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO 4J9B 4J9C 4J9D 4J9E 4J9F 4J9G 4J9H 4J9I 4JJB 4JJC 4JJD 4TWP 4WA9 4XEY 4YC8 4ZOG 5DC0 5DC4 5DC9 5HU9 5MO4 5NP2 5OAZ 6AMV 6AMW 6BL8 6NPE 6NPU 6NPV 6XR6 6XR7 6XRG 7CC2 7DT2 7N9G 7PVQ 7PVR 7PVS 7PVV 7PW2 7W7X 7W7Y 8H7F 8H7H 8I7S 8I7T 8I7Z 8SSN	3EI4 3I7L 4E54 4E5Z 6R8Y 6R8Z 6R90 6R91 6R92
GO Terms Enriched among Interactors		Intracellular Signal Transduction Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytosol Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization SH3 Domain Binding Cytoplasm Phosphotyrosine Residue Binding Protein Phosphorylation Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Developmental Process Regulation Of Apoptotic Process Phosphorylation Protein-containing Complex Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Response To Stress Plasma Membrane Enzyme Binding Peptidyl-tyrosine Phosphorylation Regulation Of Developmental Process Regulation Of Protein Localization Protein Tyrosine Kinase Activity Regulation Of Actin Filament-based Process Immune System Process Protein Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Cell Projection Organization Negative Regulation Of Apoptotic Process Regulation Of Actin Cytoskeleton Organization Cellular Response To Growth Factor Stimulus Cellular Developmental Process DNA Damage Response Regulation Of Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of MAPK Cascade Response To Stress Regulation Of Cell Population Proliferation	Damaged DNA Binding UV-damage Excision Repair Response To Radiation Nucleoplasm DNA Metabolic Process DNA Repair DNA Damage Response Nucleus Response To UV DNA Binding Cellular Response To Radiation Cellular Response To UV Macromolecule Metabolic Process Cellular Response To Light Stimulus Nucleic Acid Metabolic Process Chromatin Remodeling Rhythmic Process Cul4A-RING E3 Ubiquitin Ligase Complex Chromatin Binding Response To Light Stimulus Chromatin Organization Cellular Response To Stress Regulation Of Stem Cell Differentiation Nucleobase-containing Compound Metabolic Process Protein Modification Process Cul4-RING E3 Ubiquitin Ligase Complex Nuclear Chromosome Chromosome Regulation Of Cell Cycle Phase Transition DNA Damage Sensor Activity Chromatin Positive Regulation Of Morphogenesis Of An Epithelium Base-excision Repair, AP Site Formation Via Deaminated Base Removal Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Supercoiled DNA Binding Positive Regulation Of Blood Vessel Branching Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Morphogenesis Of A Branching Structure Nucleotide-excision Repair Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Fibroblast Proliferation Regulation Of Macromolecule Metabolic Process Chromosome Organization Regulation Of Blood Vessel Branching Bubble DNA Binding Ubiquitin Ligase Complex Scaffold Activity Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway Embryonic Cleavage