ABL1 and YWHAE

Number of citations of the paper that reports this interaction (PMID 15696159)
57

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		ABL1	YWHAE
Gene Name		ABL proto-oncogene 1, non-receptor tyrosine kinase	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Actin Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell Leading Edge Nuclear Membrane Perinuclear Region Of Cytoplasm	Mitochondrion Cytosol Kinesin Complex Focal Adhesion Membrane Axon Cytoplasmic Vesicle Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding DNA Binding Actin Monomer Binding Nicotinate-nucleotide Adenylyltransferase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding SH3 Domain Binding Syntaxin Binding Manganese Ion Binding Actin Filament Binding Mitogen-activated Protein Kinase Binding Proline-rich Region Binding	Protein Binding Potassium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding MHC Class II Protein Complex Binding Histone Deacetylase Binding Ion Channel Binding Poly(A) RNA Binding Protein Heterodimerization Activity Phosphoserine Binding Phosphoprotein Binding
	Biological Process	B-1 B Cell Homeostasis B Cell Proliferation Involved In Immune Response Transitional One Stage B Cell Differentiation Mismatch Repair Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Autophagy Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Response To Oxidative Stress Cell Cycle Arrest Mitotic Nuclear Division Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Blood Coagulation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Autophagy Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Microspike Assembly Actin Cytoskeleton Organization Regulation Of Endocytosis Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Osteoblast Proliferation Substrate Adhesion-dependent Cell Spreading Cellular Response To Oxidative Stress Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Muscle Cell Differentiation Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Spleen Development Thymus Development Collateral Sprouting Positive Regulation Of Peptidyl-tyrosine Phosphorylation Activated T Cell Proliferation B Cell Receptor Signaling Pathway Neuromuscular Process Controlling Balance Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Mitochondrial Depolarization Bergmann Glial Cell Differentiation Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Negative Regulation Of Protein Serine/threonine Kinase Activity Actin Filament Branching Positive Regulation Of Interleukin-2 Secretion Negative Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Death Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Cellular Response To Dopamine Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Cellular Senescence Regulation Of Response To DNA Damage Stimulus	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Neuron Migration Regulation Of Heart Rate By Hormone Protein Targeting Apoptotic Process Organelle Organization Viral Process Substantia Nigra Development Hippocampus Development Cerebral Cortex Development Cellular Response To Heat Hippo Signaling Intracellular Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Membrane Repolarization Membrane Organization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Heat Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-serine Dephosphorylation
Pathways		Role of Abl in Robo-Slit signaling CDO in myogenesis Axon guidance Myogenesis Fcgamma receptor (FCGR) dependent phagocytosis Factors involved in megakaryocyte development and platelet production Signaling by Robo receptor Regulation of actin dynamics for phagocytic cup formation Innate Immune System	HSF1 activation Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane G2/M Transition Activation of BH3-only proteins Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Programmed Cell Death Recruitment of mitotic centrosome proteins and complexes Intrinsic Pathway for Apoptosis Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Assembly of the primary cilium Cellular response to heat stress Regulation of HSF1-mediated heat shock response Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Activation of BAD and translocation to mitochondria Signaling by Hippo Loss of proteins required for interphase microtubule organizationÂ from the centrosome Centrosome maturation NADE modulates death signalling Mitotic G2-G2/M phases
Drugs		Adenosine triphosphate Imatinib Dasatinib N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide Nilotinib Bosutinib 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA MYRISTIC ACID 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide Regorafenib Ponatinib
Diseases
GWAS		Response to amphetamines ( 22952603)
Protein-Protein Interactions		145 interactors: ABI1 ABI2 ABL2 ACTA1 ADAM15 ANKRA2 APBB1 APP ARHGAP17 ATM ATR BCAR1 BCR BIN1 BRCA1 BTK C3 CABLES1 CABLES2 CASP9 CAT CAV1 CBL CCND2 CD19 CDK1 CDK5 CDKN1B CDON CREB1 CRK CRKL CTNND2 DDB1 DDB2 DOK1 DOK2 DOK3 EGFR ENAH EP300 EPHA3 EPHB2 ERBB2 ERBB3 ERBB4 EVL GPX1 GRB10 GRB2 GRIN2D GTF2F1 HCK HUWE1 INPPL1 JAK1 JAK2 JUN KIT LATS2 MAP4K1 MAP4K5 MAPT MAVS MBP MDM2 MICAL1 MUC1 NCK1 NCOA3 NCSTN NEDD4 NEDD4L NEDD9 NFKBIA NTRK1 PAG1 PAK2 PDE4D PIK3R1 PLCG1 PLSCR1 POLR2A PRDX1 PRKD1 PRKDC PSMA7 PSTPIP1 PTPN12 PTPN18 PTPN6 PXN RAD51 RAD52 RAD9A RAN RAPGEF1 RASA1 RB1 RFX1 RIN1 ROBO1 ROS1 RYBP SFN SH3BP1 SH3BP2 SHD SHE SLC9A2 SORBS1 SORBS2 SORBS3 SOS2 SPRR2A SPTA1 SPTAN1 SRC SRPK2 ST5 STUB1 TERT TOPBP1 TP53 TP73 TRAF6 TUB UBC VAV1 WASF1 WASF2 WASL WRNIP1 XPO1 XRCC6 YAP1 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZAP70 ZDHHC16	107 interactors: ABL1 ACD AKAP13 ANKHD1-EIF4EBP3 ARHGEF2 ARHGEF28 ATXN1 BAD BCR CALM1 CAP2 CASP3 CDC25A CDC25B CDK11B CDK14 CDK16 CDKN1B CEP95 CGNL1 CHAF1A COX2 DISC1 DYRK1A ENKD1 EXO1 FAM13B FAM53C FTH1 GAPDH GPRIN2 GRAP2 GSTA1 GTF2B HDAC4 HDAC5 HIVEP2 HSF1 IGF1R IL7R ING1 IRS1 IRS2 KCNH2 KCNK15 KCNK3 KCNK9 KIAA0232 KIF1C KRT18 LRMP MAP3K1 MAP3K10 MAP3K2 MAP3K3 MAP3K5 MAPK7 MDM4 MSL2 MST1R MYH10 NCOR2 NDEL1 NGFRAP1 PAPOLA PNLIP POT1 PRKCG RAF1 RAP1GAP2 RASAL3 RASGRF1 REM1 RGS3 RIN1 RPGR SAMSN1 SH3BP4 SLC8A1 SLC8A2 SLC8A3 SNCA SORBS2 SRC SSFA2 SYN2 TAF7 TAZ TBC1D3F TBP TFDP2 TGFB1 TLK1 TNFAIP3 TOP2A TSC1 TSC2 UBE3A VIM WNK1 WWTR1 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZNF839
Entrez ID		25	7531
HPRD ID		01809	05457
Ensembl ID		ENSG00000097007	ENSG00000108953
Uniprot IDs		P00519 Q59FK4	P62258
PDB IDs		1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU 3K2M 3PYY 3QRI 3QRJ 3QRK 3T04 3UE4 3UYO	2BR9 3UAL 3UBW
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Response To Stimulus Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Signaling Cell Communication Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stress Immune Response-regulating Cell Surface Receptor Signaling Pathway Programmed Cell Death Innate Immune Response Cell Death Death Immune System Process Apoptotic Process Immune Response-regulating Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Regulation Of Cell Death Neurotrophin Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Immune Response Cell Differentiation Response To Growth Factor Regulation Of Immune Response Cellular Response To Organic Substance Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Defense Response Regulation Of Cellular Component Organization Cell Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Process ERBB Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Locomotion Anatomical Structure Development Movement Of Cell Or Subcellular Component	Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Kinase Activity Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Cell Communication Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Response To Stimulus Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Signal Transduction Cellular Response To Organic Substance Regulation Of Cellular Process Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Factor System Development Neurotrophin TRK Receptor Signaling Pathway Developmental Process Neurotrophin Signaling Pathway Negative Regulation Of Phosphorylation Response To Organic Substance Anatomical Structure Development Multicellular Organismal Development Apoptotic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Phosphorylation Response To Organonitrogen Compound Programmed Cell Death Regulation Of Cellular Component Organization Cell Death Death Cellular Response To Organonitrogen Compound Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		aba abi1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding	aberration distinction endometrial ess fam22 federation girth guiding gynecology hgus hguss hysterectomy identifiable immunomarker jazf1 lymphadenectomy meetings multidisciplinary obstetrics oophorectomy peritoneum preferential rearrangement resemble salpingo sarcomas staged stroma undifferentiated
Tagcloud (Difference) ?		aba abi1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding	aberration distinction endometrial ess fam22 federation girth guiding gynecology hgus hguss hysterectomy identifiable immunomarker jazf1 lymphadenectomy meetings multidisciplinary obstetrics oophorectomy peritoneum preferential rearrangement resemble salpingo sarcomas staged stroma undifferentiated
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