ALPL and EEF1A1

Number of citations of the paper that reports this interaction (PubMedID 16014383)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ALPL	EEF1A1
Description		alkaline phosphatase, biomineralization associated	eukaryotic translation elongation factor 1 alpha 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Intermembrane Space Plasma Membrane Membrane Extracellular Matrix Mitochondrial Membrane Extracellular Membrane-bounded Organelle Extracellular Exosome Side Of Membrane	Extracellular Region Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Ribosome Eukaryotic Translation Elongation Factor 1 Complex Plasma Membrane Membrane Cytosolic Ribosome Cortical Actin Cytoskeleton Ruffle Membrane Secretory Granule Lumen Extracellular Exosome Cytoplasmic Side Of Lysosomal Membrane Ficolin-1-rich Granule Lumen
	Molecular Function	Alkaline Phosphatase Activity Inorganic Diphosphate Phosphatase Activity Calcium Ion Binding Pyrophosphatase Activity Hydrolase Activity Phosphatase Activity ATP Hydrolysis Activity Pyridoxal Phosphatase Activity ADP Phosphatase Activity Metal Ion Binding Phosphoamidase Activity Phosphoethanolamine Phosphatase Activity	TRNA Binding Nucleotide Binding RNA Binding Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity Kinase Activator Activity Kinase Binding Protein Kinase Binding Molecular Adaptor Activity
	Biological Process	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Developmental Process Involved In Reproduction Cellular Homeostasis Bone Mineralization Biomineral Tissue Development Response To Lipopolysaccharide Response To Insulin Response To Vitamin D Response To Vitamin B6 Response To Macrophage Colony-stimulating Factor Pyridoxal Phosphate Metabolic Process Response To Antibiotic Response To Glucocorticoid Phosphate Ion Homeostasis Calcium Ion Homeostasis Cementum Mineralization Positive Regulation Of Cold-induced Thermogenesis Futile Creatine Cycle Inhibition Of Non-skeletal Tissue Mineralization Response To Sodium Phosphate	Translation Translational Elongation Host-mediated Activation Of Viral Genome Replication Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Chaperone-mediated Autophagy
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Eukaryotic Translation Elongation Eukaryotic Translation Elongation Peptide chain elongation HSF1 activation Neutrophil degranulation Protein methylation Chaperone Mediated Autophagy SARS-CoV-1 modulates host translation machinery
Drugs		Mersalyl	Zinc Guanosine-5'-Diphosphate Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Hypophosphatasia
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) B6 vitamer levels (multivariate analysis) ( 30583557) Calcific aortic valve stenosis ( 32141789) Folate pathway vitamin levels ( 19303062 19744961) Heel bone mineral density ( 30598549) Hematological and biochemical traits ( 20139978) Kidney stones ( 31729369 26272126) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Phosphorus levels ( 29403010 20558539) Plasma pyridoxal phosphate to pyridoxal ratio ( 31641590) Pyridoxal 5'-phosphate levels ( 25972531 31641590) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Serum alkaline phosphatase levels ( 29403010 31666285 33339817 33547301) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urolithiasis ( 30975718) Vitamin B levels in ischemic stroke ( 25147783)
Interacting Genes		7 interacting genes: ALOX5 EEF1A1 LCOR MAP3K14 SRPK2 TRAF2 TRAF3	144 interacting genes: ABTB2 ACTB ALPL ANKRD24 ANXA7 APLP1 AQP2 ARIH2 AXIN1 BBS1 BBS2 BBS4 BRMS1 BTBD2 CASP2 CCL18 CDC25A CDKN1A CEBPA CKS2 CLIC6 COX17 CRADD CRCT1 CREBBP CSRP2 CTIF DARS1 DCTN1 DIABLO DLEU1 DNMT1 DNMT3A DUSP7 DYNLL1 DYSF EIF3F EP300 EXOSC4 FAS GADD45A GADD45G HOXA1 HSPB2 HSPE1 HTRA2 IKBKG IMMT ITGB1BP1 ITSN1 KCNE3 KIF1B LAMA4 LAMTOR1 LAMTOR5 LSM3 MAD2L1BP MAGED2 MAP3K14 MAPK14 MLLT3 MNAT1 MRM1 MRPL42 MTRNR2L1 MYOC NEU1 NRAS NREP OGT ORMDL3 PABPC4 PAEP PAFAH1B3 PAPSS1 PCDHA4 PFN2 PHYHIP PKN2 PLAUR PLCG1 POLE2 POLR2C PQBP1 PRKCD PSG9 PSMD11 PTPN4 PTPRCAP PTPRF RAB27A RAP2A RFC5 RGS12 RND1 RNF10 RPA2 RPLP1 RRAS RSRC1 SARS2 SDHAF2 SERPINB5 SERPINB9 SF3B4 SFN SHBG SMAD2 SMAD4 SMN1 SPATS2L SPP1 SSR1 STAT6 STMN2 SULT1E1 SUMO2 TAF9 TGIF1 TK1 TMPRSS3 TNFSF11 TP53BP2 TPT1 TRDMT1 TSC2 TSPY1 TSPYL2 TTLL12 TTR TXNIP UBQLN4 USP40 VHL WARS1 WEE2-AS1 XPO5 XRN2 YJU2B YWHAG ZBTB16 ZCCHC10 ZNF24 ZPR1
Entrez ID		249	1915
HPRD ID		01377	00559
Ensembl ID		ENSG00000162551	ENSG00000156508
Uniprot IDs		P05186	P68104 Q6IPS9
PDB IDs		7YIV 7YIW 7YIX	3C5J 6ZMO 8G60 8G6J
Enriched GO Terms of Interacting Partners?		Thioesterase Binding CD40 Receptor Complex Immune Response Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Defense Response Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Arachidonate 8(S)-lipoxygenase Activity Immune System Process Protein Kinase Binding Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo TORC2 Complex Disassembly Protein Phosphatase Binding Tumor Necrosis Factor-mediated Signaling Pathway TRAF2-GSTP1 Complex Signaling Adaptor Activity TORC1 Complex Assembly CD40 Receptor Binding Response To Other Organism Ubiquitin Ligase Complex Cytoplasmic Side Of Plasma Membrane Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Ficolin-1-rich Granule Lumen Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Secretory Granule Lumen Arachidonate Metabolite Production Involved In Inflammatory Response Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Eukaryotic Translation Elongation Factor 1 Complex Response To External Biotic Stimulus Nuclear Speck Organization Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Nerve Growth Factor Binding CD27 Signaling Pathway Innate Immune Response Negative Regulation Of Vascular Wound Healing Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Toll Signaling Pathway Leukocyte Chemotaxis Involved In Inflammatory Response Regulation Of Chaperone-mediated Autophagy	Cytoplasm Apoptotic Process Cell Death Programmed Cell Death Regulation Of Programmed Cell Death Cytosol Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Negative Regulation Of Metabolic Process Regulation Of Apoptotic Process Nucleic Acid Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway BBSome Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling Protein-containing Complex Nucleus Macromolecule Biosynthetic Process Melanosome Transport Tau Protein Binding Regulation Of Developmental Process RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Establishment Of Melanosome Localization Pigment Granule Transport Negative Regulation Of Protein Phosphorylation Cellular Response To Stress Melanosome Localization Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Macromolecule Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Pigment Granule Localization Mitochondrial Intermembrane Space Nucleoplasm Protein Binding Negative Regulation Of Catalytic Activity Histone H3K27 Acetyltransferase Activity Negative Regulation Of Phosphate Metabolic Process TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Phosphorus Metabolic Process
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