ALPL and MAP3K14

Number of citations: 0 (PubMedID 15208311)
Data Source: HPRD (two hybrid, in vivo)

		ALPL	MAP3K14
Name		alkaline phosphatase, biomineralization associated	mitogen-activated protein kinase kinase kinase 14
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Intermembrane Space Plasma Membrane Membrane Extracellular Matrix Mitochondrial Membrane Extracellular Membrane-bounded Organelle Extracellular Exosome Side Of Membrane	Fibrillar Center Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Alkaline Phosphatase Activity Inorganic Diphosphate Phosphatase Activity Calcium Ion Binding Pyrophosphatase Activity Hydrolase Activity Phosphatase Activity ATP Hydrolysis Activity Pyridoxal Phosphatase Activity ADP Phosphatase Activity Metal Ion Binding Phosphoamidase Activity Phosphoethanolamine Phosphatase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Developmental Process Involved In Reproduction Cellular Homeostasis Bone Mineralization Biomineral Tissue Development Response To Lipopolysaccharide Response To Insulin Response To Vitamin D Response To Vitamin B6 Response To Macrophage Colony-stimulating Factor Pyridoxal Phosphate Metabolic Process Response To Antibiotic Response To Glucocorticoid Phosphate Ion Homeostasis Calcium Ion Homeostasis Cementum Mineralization Positive Regulation Of Cold-induced Thermogenesis Futile Creatine Cycle Inhibition Of Non-skeletal Tissue Mineralization Response To Sodium Phosphate	MAPK Cascade Immune Response Non-canonical NF-kappaB Signal Transduction Defense Response To Virus Cellular Response To Mechanical Stimulus
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Mersalyl	None
Diseases		Hypophosphatasia	None
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065 ) B6 vitamer levels (multivariate analysis) ( 30583557 ) Calcific aortic valve stenosis ( 32141789 ) Folate pathway vitamin levels ( 19303062 19744961 ) Heel bone mineral density ( 30598549 ) Hematological and biochemical traits ( 20139978 ) Kidney stones ( 31729369 26272126 ) Liver enzyme levels ( 18940312 ) Liver enzyme levels (alkaline phosphatase) ( 22001757 ) Metabolic traits ( 21886157 ) Metabolite levels ( 23823483 ) Phosphorus levels ( 29403010 20558539 ) Plasma pyridoxal phosphate to pyridoxal ratio ( 31641590 ) Pyridoxal 5'-phosphate levels ( 25972531 31641590 ) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225 ) Serum alkaline phosphatase levels ( 29403010 31666285 33339817 33547301 ) Serum metabolite levels ( 33031748 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urolithiasis ( 30975718 ) Vitamin B levels in ischemic stroke ( 25147783 )	Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Asthma ( 30929738 31361310 31619474 31959851 ) Asthma (childhood onset) ( 30929738 ) Asthma onset (childhood vs adult) ( 30929738 ) Cognitive function ( 28093568 ) Joint damage in rheumatoid arthritis ( 26498133 ) Male-pattern baldness ( 28196072 ) Multiple sclerosis ( 21833088 31604244 ) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Plateletcrit ( 32888494 )
Interacting Genes		7 interacting genes: ALOX5 EEF1A1 LCOR MAP3K14 SRPK2 TRAF2 TRAF3	42 interacting genes: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR ELP1 FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 SLC9A1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 ZFP91
Entrez ID		249	9020
HPRD ID		01377	05230
Ensembl ID		ENSG00000162551	ENSG00000006062
Uniprot IDs		P05186	Q99558
PDB IDs		7YIV 7YIW 7YIX	4DN5 4G3D 4IDT 4IDV 6WPP 6Z1Q 6Z1T 8YHW
GO Terms Enriched among Interactors		Thioesterase Binding CD40 Receptor Complex Immune Response Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Defense Response Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Arachidonate 8(S)-lipoxygenase Activity Immune System Process Protein Kinase Binding Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo TORC2 Complex Disassembly Protein Phosphatase Binding Tumor Necrosis Factor-mediated Signaling Pathway TRAF2-GSTP1 Complex Signaling Adaptor Activity TORC1 Complex Assembly CD40 Receptor Binding Response To Other Organism Ubiquitin Ligase Complex Cytoplasmic Side Of Plasma Membrane Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Ficolin-1-rich Granule Lumen Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Secretory Granule Lumen Arachidonate Metabolite Production Involved In Inflammatory Response Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Eukaryotic Translation Elongation Factor 1 Complex Response To External Biotic Stimulus Nuclear Speck Organization Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Nerve Growth Factor Binding CD27 Signaling Pathway Innate Immune Response Negative Regulation Of Vascular Wound Healing Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Toll Signaling Pathway Leukocyte Chemotaxis Involved In Inflammatory Response Regulation Of Chaperone-mediated Autophagy	Tumor Necrosis Factor-mediated Signaling Pathway Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Intracellular Signaling Cassette Positive Regulation Of Canonical NF-kappaB Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signal Transduction Cytosol Tumor Necrosis Factor Receptor Binding Cytoplasm Positive Regulation Of DNA-binding Transcription Factor Activity Response To Cytokine Response To Peptide Response To Tumor Necrosis Factor Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Signaling Adaptor Activity Regulation Of Intracellular Signal Transduction Cytosolic Ribosome Response To External Biotic Stimulus Cellular Response To Tumor Necrosis Factor Regulation Of Protein Metabolic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Thioesterase Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Regulation Of Primary Metabolic Process Ubiquitin Protein Ligase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Scaffold Protein Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Transferase Activity Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Defense Response Toll-like Receptor 4 Signaling Pathway Focal Adhesion Intracellular Signal Transduction Positive Regulation Of Signal Transduction