ALPL and LCOR

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ALPL	LCOR
Description		alkaline phosphatase, biomineralization associated	ligand dependent nuclear receptor corepressor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Intermembrane Space Plasma Membrane Membrane Extracellular Matrix Mitochondrial Membrane Extracellular Membrane-bounded Organelle Extracellular Exosome Side Of Membrane	Nucleus Nucleoplasm
	Molecular Function	Alkaline Phosphatase Activity Inorganic Diphosphate Phosphatase Activity Calcium Ion Binding Pyrophosphatase Activity Hydrolase Activity Phosphatase Activity ATP Hydrolysis Activity Pyridoxal Phosphatase Activity ADP Phosphatase Activity Metal Ion Binding Phosphoamidase Activity Phosphoethanolamine Phosphatase Activity	Transcription Corepressor Binding DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Estrogen Receptor Binding Histone Deacetylase Binding Histone Methyltransferase Binding Ubiquitin-specific Protease Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Developmental Process Involved In Reproduction Cellular Homeostasis Bone Mineralization Biomineral Tissue Development Response To Lipopolysaccharide Response To Insulin Response To Vitamin D Response To Vitamin B6 Response To Macrophage Colony-stimulating Factor Pyridoxal Phosphate Metabolic Process Response To Antibiotic Response To Glucocorticoid Phosphate Ion Homeostasis Calcium Ion Homeostasis Cementum Mineralization Positive Regulation Of Cold-induced Thermogenesis Futile Creatine Cycle Inhibition Of Non-skeletal Tissue Mineralization Response To Sodium Phosphate	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus
Pathways		Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Mersalyl
Diseases		Hypophosphatasia
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) B6 vitamer levels (multivariate analysis) ( 30583557) Calcific aortic valve stenosis ( 32141789) Folate pathway vitamin levels ( 19303062 19744961) Heel bone mineral density ( 30598549) Hematological and biochemical traits ( 20139978) Kidney stones ( 31729369 26272126) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Phosphorus levels ( 29403010 20558539) Plasma pyridoxal phosphate to pyridoxal ratio ( 31641590) Pyridoxal 5'-phosphate levels ( 25972531 31641590) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Serum alkaline phosphatase levels ( 29403010 31666285 33339817 33547301) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urolithiasis ( 30975718) Vitamin B levels in ischemic stroke ( 25147783)	Peak height velocity ( 34047840) Simvastatin-induced myopathy ( 31220337) Waist circumference ( 28552196)
Interacting Genes		7 interacting genes: ALOX5 EEF1A1 LCOR MAP3K14 SRPK2 TRAF2 TRAF3	144 interacting genes: ABCA2 ABCF1 ACAD8 ACOT1 ACTB ADAM22 AIP ALDOA ALPL AR ARFGEF2 ARHGAP1 ATM ATP5F1B ATP6V1B2 ATRNL1 B4GAT1 BIRC7 CA11 CABIN1 CCT2 CEP57L1 CEP70 CERCAM CFH CHPF CLU CNTNAP1 COPS4 COPS5 CREBZF CS CTSB CYRIA DCTN1 DENND6B DGLUCY DNAJC7 DNMT1 DYNC1I1 ECE2 EEF2 EIF2AK1 EIF3F EIF4G2 ENPP2 ESR1 EXTL3 FAM120A FAM86B1 FBXW4 FLII FMNL2 FOLH1 FPGT-TNNI3K GALNT2 GAMT GATM GDAP1L1 GLIPR1 GLUL GM2A GNB1 GOLGA2 GRHPR GSK3A GUK1 HDAC1 HDAC3 HDAC4 HDAC6 HLA-B HSPA9 IDS IFT172 IQGAP1 JMJD7-PLA2G4B KCNAB2 KLF6 LDB1 LRP1B LRP4 LRRC4 LRRN2 MACF1 MAGI2 MAP3K10 MED13 MERTK MICAL2 MLST8 MOAP1 MTMR10 MYCBP2 NAV3 NDST1 NDUFA10 NGEF NR3C1 NRCAM NUP42 OAT P4HTM PAICS PC PDGFRB PLEKHB1 PPT1 PSMB4 PSMD5 PTPRA QTRT1 RANBP9 RAP1GAP RAP1GDS1 RNF123 RORB SDCBP SDHA SEC31A SERGEF SMYD3 SNRNP200 SPARCL1 STAMBPL1 STX18 SUPT20H SYNGAP1 TAF1 TF THAP4 TM2D3 TPP1 TRAF1 TRIOBP TRIP12 TTC3 TTLL12 TUBG2 UBA7 VDR VWF WARS1 YWHAE
Entrez ID		249	84458
HPRD ID		01377	07609
Ensembl ID		ENSG00000162551	ENSG00000196233
Uniprot IDs		P05186	Q96JN0
PDB IDs		7YIV 7YIW 7YIX	2COB 6V3X 6V3Y
Enriched GO Terms of Interacting Partners?		Thioesterase Binding CD40 Receptor Complex Immune Response Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Defense Response Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Arachidonate 8(S)-lipoxygenase Activity Immune System Process Protein Kinase Binding Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo TORC2 Complex Disassembly Protein Phosphatase Binding Tumor Necrosis Factor-mediated Signaling Pathway TRAF2-GSTP1 Complex Signaling Adaptor Activity TORC1 Complex Assembly CD40 Receptor Binding Response To Other Organism Ubiquitin Ligase Complex Cytoplasmic Side Of Plasma Membrane Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Ficolin-1-rich Granule Lumen Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Secretory Granule Lumen Arachidonate Metabolite Production Involved In Inflammatory Response Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Eukaryotic Translation Elongation Factor 1 Complex Response To External Biotic Stimulus Nuclear Speck Organization Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Nerve Growth Factor Binding CD27 Signaling Pathway Innate Immune Response Negative Regulation Of Vascular Wound Healing Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Toll Signaling Pathway Leukocyte Chemotaxis Involved In Inflammatory Response Regulation Of Chaperone-mediated Autophagy	Cytosol Histone Deacetylase Activity, Hydrolytic Mechanism Protein Metabolic Process Macromolecule Deacylation Protein Deacetylation Protein Lysine Deacetylase Activity Cell Leading Edge Histone Deacetylase Activity Cytoplasm Tau Protein Binding Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Precursor Protein Catabolic Process Creatine Biosynthetic Process Deacetylase Activity Extracellular Exosome Nuclear Receptor Activity Estrogen Response Element Binding Dicarboxylic Acid Metabolic Process Glutamate Metabolic Process Metal-dependent Deubiquitinase Activity Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Creatine Metabolic Process Protein Lysine Delactylase Activity Transferase Activity Regulation Of Post-translational Protein Modification Cadherin Binding Negative Regulation Of Muscle Cell Differentiation Mammary Gland Branching Involved In Pregnancy Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Histone Deacetylase Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Modification Process Positive Regulation Of Protein Metabolic Process Response To Steroid Hormone Response To Dexamethasone Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Amyloid-beta Formation Translational Initiation Axon Regulation Of Receptor-mediated Endocytosis Protein Polyubiquitination Microtubule Mitochondrial Matrix RNA Polymerase II Core Promoter Sequence-specific DNA Binding
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