ALPL and PCSK6

		ALPL	PCSK6
Description		alkaline phosphatase, biomineralization associated	proprotein convertase subtilisin/kexin type 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Mitochondrial Intermembrane Space Plasma Membrane Membrane Extracellular Matrix Mitochondrial Membrane Extracellular Membrane-bounded Organelle Extracellular Exosome Side Of Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Endomembrane System Membrane Extracellular Matrix
	Molecular Function	Alkaline Phosphatase Activity Inorganic Diphosphate Phosphatase Activity Calcium Ion Binding Pyrophosphatase Activity Hydrolase Activity Phosphatase Activity ATP Hydrolysis Activity Pyridoxal Phosphatase Activity ADP Phosphatase Activity Metal Ion Binding Phosphoamidase Activity Phosphoethanolamine Phosphatase Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Nerve Growth Factor Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Developmental Process Involved In Reproduction Cellular Homeostasis Bone Mineralization Biomineral Tissue Development Response To Lipopolysaccharide Response To Insulin Response To Vitamin D Response To Vitamin B6 Response To Macrophage Colony-stimulating Factor Pyridoxal Phosphate Metabolic Process Response To Antibiotic Response To Glucocorticoid Phosphate Ion Homeostasis Calcium Ion Homeostasis Cementum Mineralization Positive Regulation Of Cold-induced Thermogenesis Futile Creatine Cycle Inhibition Of Non-skeletal Tissue Mineralization Response To Sodium Phosphate	Proteolysis Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Production Secretion By Cell Plasma Lipoprotein Particle Remodeling
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
Drugs		Mersalyl
Diseases		Hypophosphatasia
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) B6 vitamer levels (multivariate analysis) ( 30583557) Calcific aortic valve stenosis ( 32141789) Folate pathway vitamin levels ( 19303062 19744961) Heel bone mineral density ( 30598549) Hematological and biochemical traits ( 20139978) Kidney stones ( 31729369 26272126) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Phosphorus levels ( 29403010 20558539) Plasma pyridoxal phosphate to pyridoxal ratio ( 31641590) Pyridoxal 5'-phosphate levels ( 25972531 31641590) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Serum alkaline phosphatase levels ( 29403010 31666285 33339817 33547301) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urolithiasis ( 30975718) Vitamin B levels in ischemic stroke ( 25147783)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Platelet-derived growth factor BB levels ( 27989323) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Severe coronary stenosis (young age of onset interaction) ( 33766035) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)
Interacting Genes		7 interacting genes: ALOX5 EEF1A1 LCOR MAP3K14 SRPK2 TRAF2 TRAF3	7 interacting genes: CACNA1A DYRK1A FLG PCSK5 PMCH RCN3 ZNF441
Entrez ID		249	5046
HPRD ID		01377	01329
Ensembl ID		ENSG00000162551	ENSG00000140479
Uniprot IDs		P05186	A2RQD9 H7BXT3 P29122 Q59H04
PDB IDs		7YIV 7YIW 7YIX
Enriched GO Terms of Interacting Partners?		Thioesterase Binding CD40 Receptor Complex Immune Response Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Defense Response Leukotriene A4 Metabolic Process Leukotriene Production Involved In Inflammatory Response Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Arachidonate 8(S)-lipoxygenase Activity Immune System Process Protein Kinase Binding Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo TORC2 Complex Disassembly Protein Phosphatase Binding Tumor Necrosis Factor-mediated Signaling Pathway TRAF2-GSTP1 Complex Signaling Adaptor Activity TORC1 Complex Assembly CD40 Receptor Binding Response To Other Organism Ubiquitin Ligase Complex Cytoplasmic Side Of Plasma Membrane Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Ficolin-1-rich Granule Lumen Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Secretory Granule Lumen Arachidonate Metabolite Production Involved In Inflammatory Response Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Eukaryotic Translation Elongation Factor 1 Complex Response To External Biotic Stimulus Nuclear Speck Organization Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Nerve Growth Factor Binding CD27 Signaling Pathway Innate Immune Response Negative Regulation Of Vascular Wound Healing Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Toll Signaling Pathway Leukocyte Chemotaxis Involved In Inflammatory Response Regulation Of Chaperone-mediated Autophagy	Phosphoethanolamine Phosphatase Activity Response To Vitamin B6 Futile Creatine Cycle Phosphoamidase Activity Extracellular Membrane-bounded Organelle Response To Amyloid-beta Cellular Response To Amyloid-beta Peptidyl-tyrosine Phosphorylation Histone H3T45 Kinase Activity Type 1 Melanin-concentrating Hormone Receptor Binding Negative Regulation Of Synaptic Transmission, Dopaminergic Melanin-concentrating Hormone Activity Neurofilament Cytoskeleton Fast-twitch Skeletal Muscle Fiber Contraction Protein-fructosamine 3-kinase Activity Fructosamine Metabolic Process Protein Deglycation Protein-ribulosamine 3-kinase Activity Fructoselysine Metabolic Process
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