ALPL

Gene Name		alkaline phosphatase, liver/bone/kidney
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Integral Component Of Membrane Extracellular Matrix Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Alkaline Phosphatase Activity Protein Binding Pyrophosphatase Activity Metal Ion Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Developmental Process Involved In Reproduction Dephosphorylation Response To Lipopolysaccharide Response To Vitamin D Response To Antibiotic Response To Glucocorticoid Cellular Response To Organic Cyclic Compound Cementum Mineralization
Pathways
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Folate pathway vitamin levels ( 19303062 19744961) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic traits ( 21886157) Phosphorus levels ( 20558539) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225)
Protein-protein Interactions		4 interactors: EEF1A1 MAP3K14 TRAF2 TRAF3
Entrez ID		249
HPRD ID		01377
Ensembl ID		ENSG00000162551
Uniprot IDs		P05186
PDB IDs
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Tumor Necrosis Factor Toll-like Receptor Signaling Pathway Response To Tumor Necrosis Factor Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Regulation Of Immune System Process Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Glial Cell Apoptotic Process Cellular Protein Metabolic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Protein Homodimerization Activity Toll Signaling Pathway Cellular Response To Nitric Oxide Cellular Response To Organic Substance Cytokine-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Immunoglobulin Secretion Response To Nitric Oxide Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Cell Activation Positive Regulation Of Kinase Activity Immune System Process Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Protein Metabolic Process Positive Regulation Of T Cell Cytokine Production
Tagcloud ?		abcc6 bmp2 bmps calcification comes ectonucleotides elasticum enpp1 extrapolate localizing mineralisation mineralization msx2 multisystem neovascularisation osteoinductive papular perturbed pseudoxanthoma pxe runx2 smad2 smads stains subretinal tgfbeta tgfbeta1 tgfbetas whiskers