GABARAPL1 and MAP4K2

Number of citations of the paper that reports this interaction (PubMedID 32640226)
55

Data Source:
BioGRID (pull down, affinity chromatography technology)

		GABARAPL1	MAP4K2
Description		GABA type A receptor associated protein like 1	mitogen-activated protein kinase kinase kinase kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body	Golgi Membrane Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity
	Biological Process	Autophagosome Assembly Mitophagy Autophagy Cellular Response To Nitrogen Starvation Glycophagy Autophagosome Maturation	Immune System Process Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of JNK Cascade
Pathways		Macroautophagy
Drugs			Fostamatinib
Diseases
GWAS			Serum uric acid levels ( 32514006) Urate levels ( 21768215)
Interacting Genes		87 interacting genes: AHNAK2 AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG4A ATG4B ATG4D AZI2 BICC1 BNIP3L BRD9 BSCL2 BSDC1 CALCOCO1 CALCOCO2 CARS2 CCT2 CDC37 CREB3L2 CUL3 DISC1 DVL2 DYNLL1 ERBB2 ERBB3 FUNDC1 G3BP1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 KXD1 MAP4K2 MAPK15 MEFV MLX MYBPC1 NCOR1 NEDD4 NFIA NUFIP2 OPRK1 OPTN OSBPL3 PBXIP1 PSMB4 PTPRR RABGAP1 RABGAP1L RB1CC1 RCN2 RESF1 RETREG3 SCYL3 SEC62 SNCA SQSTM1 SRPK1 SRPK2 STK3 STRN3 TAX1BP1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B THAP7 TMEM131 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 UMAD1 VDR WDFY3 ZBTB22	19 interacting genes: DEFB1 GABARAP GABARAPL1 GABARAPL2 HNRNPA2B1 LATS1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A SERPINA4 SNCA SNRNP35 STRN4 TRAF2 XRCC6
Entrez ID		23710	5871
HPRD ID		07601	04408
Ensembl ID		ENSG00000139112	ENSG00000168067
Uniprot IDs		Q9H0R8	Q12851
PDB IDs		2L8J 2R2Q 5DPT 5LXH 5LXI 6HOI 6HOL 6YOO 7AA7 7AA9 7JHX 8X8A
Enriched GO Terms of Interacting Partners?		Autophagosome Regulation Of Cilium Assembly Autophagy Macroautophagy GTPase Activator Activity Regulation Of Organelle Assembly Cytosol Regulation Of Autophagy Positive Regulation Of Autophagy Autophagy Of Mitochondrion Regulation Of Cell Projection Assembly Mitophagy Autophagosome Assembly Autophagosome Organization Aggrephagy Cytoplasmic Vesicle Piecemeal Microautophagy Of The Nucleus Cytoplasm Regulation Of Cell Projection Organization Microautophagy Nucleophagy Positive Regulation Of Catabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Vacuole Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Protein-phosphatidylethanolamide Deconjugating Activity Catabolic Process Protein Delipidation Response To Mitochondrial Depolarisation Organelle Assembly Regulation Of Macroautophagy Atg1/ULK1 Kinase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macroautophagy Regulation Of Intracellular Signal Transduction Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Phagophore Assembly Site Negative Regulation Of Signal Transduction ERBB3:ERBB2 Complex Protein Localization To Phagocytic Vesicle Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Viral Process	Beta-tubulin Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding GABA Receptor Binding Phospholipid Binding Single-stranded Telomeric DNA Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Disassembly Autophagosome Maturation Autophagosome Membrane Mitophagy Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Regulation Of Protein Modification Process Positive Regulation Of JUN Kinase Activity Autophagy Of Mitochondrion Autophagosome Regulation Of Protein Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Protein Metabolic Process Autophagosome Assembly Regulation Of Kinase Activity Cellular Response To Stress Autophagosome Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Autophagy Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Kinase Activity Telomeric DNA Binding Positive Regulation Of Kinase Activity Chromosome Organization Non-canonical NF-kappaB Signal Transduction Protein-containing Complex Binding Positive Regulation Of Protein Modification Process Positive Regulation Of MAP Kinase Activity Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Macroautophagy Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Protein Phosphorylation Chromosome, Telomeric Region Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission
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