GABARAPL1 and STK3

Number of citations of the paper that reports this interaction (PubMedID 31857374)
66

Data Source:
BioGRID (pull down)

		GABARAPL1	STK3
Description		GABA type A receptor associated protein like 1	serine/threonine kinase 3
Image
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Protein-containing Complex
	Molecular Function	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity Transcription Regulator Activator Activity
	Biological Process	Autophagosome Assembly Mitophagy Autophagy Cellular Response To Nitrogen Starvation Glycophagy Autophagosome Maturation	Neural Tube Formation Endocardium Development Protein Phosphorylation Protein Import Into Nucleus Apoptotic Process Signal Transduction JNK Cascade Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Organ Growth Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Protein Tetramerization Centrosome Separation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Protein Localization To Centrosome Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Macroautophagy	Signaling by Hippo
Drugs			Fostamatinib
Diseases
GWAS			Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)
Interacting Genes		87 interacting genes: AHNAK2 AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG4A ATG4B ATG4D AZI2 BICC1 BNIP3L BRD9 BSCL2 BSDC1 CALCOCO1 CALCOCO2 CARS2 CCT2 CDC37 CREB3L2 CUL3 DISC1 DVL2 DYNLL1 ERBB2 ERBB3 FUNDC1 G3BP1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 KXD1 MAP4K2 MAPK15 MEFV MLX MYBPC1 NCOR1 NEDD4 NFIA NUFIP2 OPRK1 OPTN OSBPL3 PBXIP1 PSMB4 PTPRR RABGAP1 RABGAP1L RB1CC1 RCN2 RESF1 RETREG3 SCYL3 SEC62 SNCA SQSTM1 SRPK1 SRPK2 STK3 STRN3 TAX1BP1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B THAP7 TMEM131 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 UMAD1 VDR WDFY3 ZBTB22	41 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GABARAP GABARAPL1 GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS2 LRRK2 MAP1LC3B MAP1LC3C MARK2 MBP MOB3B MOB4 MPP1 OGT ORM2 PEX19 PIN1 QARS1 RAF1 RASSF4 SAV1 SLMAP SNIP1 SULT2A1 TFPT TRAF1 TRIM21 TRIM69 ZC3H7A
Entrez ID		23710	6788
HPRD ID		07601	05433
Ensembl ID		ENSG00000139112	ENSG00000104375
Uniprot IDs		Q9H0R8	A0A087WZ06 A0A384MR07 Q13188
PDB IDs		2L8J 2R2Q 5DPT 5LXH 5LXI 6HOI 6HOL 6YOO 7AA7 7AA9 7JHX 8X8A	3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2 8A66
Enriched GO Terms of Interacting Partners?		Autophagosome Regulation Of Cilium Assembly Autophagy Macroautophagy GTPase Activator Activity Regulation Of Organelle Assembly Cytosol Regulation Of Autophagy Positive Regulation Of Autophagy Autophagy Of Mitochondrion Regulation Of Cell Projection Assembly Mitophagy Autophagosome Assembly Autophagosome Organization Aggrephagy Cytoplasmic Vesicle Piecemeal Microautophagy Of The Nucleus Cytoplasm Regulation Of Cell Projection Organization Microautophagy Nucleophagy Positive Regulation Of Catabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Vacuole Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Protein-phosphatidylethanolamide Deconjugating Activity Catabolic Process Protein Delipidation Response To Mitochondrial Depolarisation Organelle Assembly Regulation Of Macroautophagy Atg1/ULK1 Kinase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macroautophagy Regulation Of Intracellular Signal Transduction Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Phagophore Assembly Site Negative Regulation Of Signal Transduction ERBB3:ERBB2 Complex Protein Localization To Phagocytic Vesicle Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Viral Process	Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Regulation Of Hippo Signaling Cytoplasm Mitophagy Autophagosome Cellular Response To Nutrient Levels Autophagosome Assembly Vacuole Organization Cellular Response To Starvation Autophagosome Organization Regulation Of Intracellular Signal Transduction Autophagy Autophagosome Maturation Positive Regulation Of Proteolysis Intracellular Signal Transduction Autophagosome Membrane Response To Starvation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosol Protein-containing Complex Disassembly Negative Regulation Of Hippo Signaling Hippo Signaling Apoptotic Process Macroautophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Programmed Cell Death Protein Binding Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Organ Growth Signal Transduction Protein-containing Complex Organization Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Response To Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication Pyroptotic Inflammatory Response Regulation Of Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Proteasomal Protein Catabolic Process Protein Serine Kinase Activity
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