GABARAPL1 and TMEM131

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GABARAPL1	TMEM131
Description		GABA type A receptor associated protein like 1	transmembrane protein 131
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body	Membrane
	Molecular Function	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Collagen Binding
	Biological Process	Autophagosome Assembly Mitophagy Autophagy Cellular Response To Nitrogen Starvation Glycophagy Autophagosome Maturation	Collagen Biosynthetic Process
Pathways		Macroautophagy
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		87 interacting genes: AHNAK2 AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG4A ATG4B ATG4D AZI2 BICC1 BNIP3L BRD9 BSCL2 BSDC1 CALCOCO1 CALCOCO2 CARS2 CCT2 CDC37 CREB3L2 CUL3 DISC1 DVL2 DYNLL1 ERBB2 ERBB3 FUNDC1 G3BP1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 KXD1 MAP4K2 MAPK15 MEFV MLX MYBPC1 NCOR1 NEDD4 NFIA NUFIP2 OPRK1 OPTN OSBPL3 PBXIP1 PSMB4 PTPRR RABGAP1 RABGAP1L RB1CC1 RCN2 RESF1 RETREG3 SCYL3 SEC62 SNCA SQSTM1 SRPK1 SRPK2 STK3 STRN3 TAX1BP1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B THAP7 TMEM131 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 UMAD1 VDR WDFY3 ZBTB22	3 interacting genes: GABARAPL1 NRIP1 RACK1
Entrez ID		23710	23505
HPRD ID		07601	19388
Ensembl ID		ENSG00000139112	ENSG00000075568
Uniprot IDs		Q9H0R8	Q92545
PDB IDs		2L8J 2R2Q 5DPT 5LXH 5LXI 6HOI 6HOL 6YOO 7AA7 7AA9 7JHX 8X8A
Enriched GO Terms of Interacting Partners?		Autophagosome Regulation Of Cilium Assembly Autophagy Macroautophagy GTPase Activator Activity Regulation Of Organelle Assembly Cytosol Regulation Of Autophagy Positive Regulation Of Autophagy Autophagy Of Mitochondrion Regulation Of Cell Projection Assembly Mitophagy Autophagosome Assembly Autophagosome Organization Aggrephagy Cytoplasmic Vesicle Piecemeal Microautophagy Of The Nucleus Cytoplasm Regulation Of Cell Projection Organization Microautophagy Nucleophagy Positive Regulation Of Catabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Vacuole Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Protein-phosphatidylethanolamide Deconjugating Activity Catabolic Process Protein Delipidation Response To Mitochondrial Depolarisation Organelle Assembly Regulation Of Macroautophagy Atg1/ULK1 Kinase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macroautophagy Regulation Of Intracellular Signal Transduction Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Phagophore Assembly Site Negative Regulation Of Signal Transduction ERBB3:ERBB2 Complex Protein Localization To Phagocytic Vesicle Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Viral Process	Ovulation Signaling Receptor Binding Rhythmic Process Nuclear Glucocorticoid Receptor Binding Ovarian Follicle Rupture Negative Regulation Of Translational Elongation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Membrane Depolarization Positive Regulation Of Gastrulation Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Positive Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Translational Elongation Regulation Of Gastrulation Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death IRE1-RACK1-PP2A Complex Positive Regulation Of Mitochondrial Depolarization Ion Channel Inhibitor Activity Regulation Of Golgi To Plasma Membrane Protein Transport BH3 Domain Binding Negative Regulation Of Translational Frameshifting Protein Tyrosine Kinase Inhibitor Activity Phosphatidylethanolamine Binding Cellular Response To Nitrogen Starvation Tat Protein Binding Glycophagy Nuclear Retinoid X Receptor Binding Nuclear Retinoic Acid Receptor Binding Positive Regulation Of Embryonic Development Translation Regulator Activity GABA Receptor Binding Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Phagocytosis Regulation Of Mitochondrial Depolarization Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Glycogen Catabolic Process Regulation Of Establishment Of Cell Polarity Polysaccharide Catabolic Process Regulation Of Establishment Or Maintenance Of Cell Polarity Protein Serine/threonine Kinase Inhibitor Activity Small Ribosomal Subunit Phagocytic Cup Negative Regulation Of Protein Binding Cellular Response To Estradiol Stimulus Lipid Storage Cyclin Binding Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Rescue Of Stalled Ribosome Negative Regulation Of Smoothened Signaling Pathway Cytosolic Small Ribosomal Subunit
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