GABARAPL1 and MAPK15

Number of citations of the paper that reports this interaction (PMID 22948227)
9

Data Source:
BioGRID (pull down, affinity chromatography technology)

		GABARAPL1	MAPK15
Gene Name		GABA(A) receptor-associated protein like 1	mitogen-activated protein kinase 15
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Autophagic Vacuole Membrane Intracellular Autophagic Vacuole Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Dendrite Membrane Dendrite Cytoplasm Cell Body	Extracellular Region Intracellular Nucleus
	Molecular Function	Protein Binding Microtubule Binding Tat Protein Binding Beta-tubulin Binding GABA Receptor Binding	MAP Kinase Activity ATP Binding SH3 Domain Binding
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation Nucleophagy Membrane Fusion	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Positive Regulation Of Protein Phosphorylation Negative Regulation Of DNA Replication Positive Regulation Of Protein Ubiquitination Response To Estradiol Positive Regulation Of Protein Catabolic Process Protein Autophosphorylation
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		35 interactors: AHNAK2 ATG4A ATG4B ATG4D CALCOCO2 DVL2 FAM134C FUNDC1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 MAPK15 OPRK1 RABGAP1 RABGAP1L SCYL3 SNCA SQSTM1 SRPK1 SRPK2 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TNIP1 VDR	8 interactors: CLIC3 CSK GABARAP GABARAPL1 MBP NR3C1 SRC TGFB1I1
Entrez ID		23710	225689
HPRD ID		07601	16867
Ensembl ID		ENSG00000139112	ENSG00000181085
Uniprot IDs		Q9H0R8	Q8TD08
PDB IDs		2L8J 2R2Q
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Positive Regulation Of Ras GTPase Activity Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Autophagy Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Signaling Protein Delipidation Mitochondrion Degradation Organelle Disassembly Regulation Of Metabolic Process Macroautophagy Cellular Response To Nitrogen Starvation Retrograde Transport, Endosome To Golgi Cellular Response To Nutrient Levels Nucleophagy Response To Starvation C-terminal Protein Lipidation Endosomal Transport Cellular Response To Extracellular Stimulus Protein Processing Response To Nutrient Levels Positive Regulation Of Autophagy Response To Extracellular Stimulus Autophagic Vacuole Assembly Cellular Response To Starvation Negative Regulation Of Viral Genome Replication Regulation Of Viral Genome Replication Mitochondrion Organization Negative Regulation Of Viral Process Vacuole Organization Regulation Of Autophagy Positive Regulation Of Viral Genome Replication Protein Lipidation Intracellular Transport Lipoprotein Biosynthetic Process Cellular Localization Response To Stress Establishment Of Localization In Cell Positive Regulation Of Protein Metabolic Process	Intracellular Steroid Hormone Receptor Signaling Pathway Cell Communication Morphogenesis Of An Epithelium Nucleophagy Intracellular Receptor Signaling Pathway Tissue Morphogenesis Mitochondrion Degradation Regulation Of Bone Resorption Organelle Disassembly Peptidyl-tyrosine Autophosphorylation Regulation Of Bone Remodeling Autophagic Vacuole Assembly Membrane Organization Response To Progesterone Response To Hormone Macroautophagy Mammary Gland Duct Morphogenesis Response To Stress Regulation Of Tissue Remodeling Response To Stimulus Response To Fatty Acid Epithelium Development Negative Regulation Of Signal Transduction Signaling T Cell Costimulation Response To Nutrient Levels Mammary Gland Morphogenesis Glucocorticoid Mediated Signaling Pathway Adherens Junction Organization Negative Regulation Of Signaling Response To Extracellular Stimulus Response To Steroid Hormone Mammary Gland Epithelium Development Regulation Of Glucose Metabolic Process Vacuole Organization Regulation Of Cytokine Production Cellular Response To Progesterone Stimulus Cellular Response To Hormone Stimulus Cellular Response To Stimulus Membrane Fusion Cellular Response To Starvation Defense Response To Nematode Negative Regulation Of Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Carbohydrate Metabolic Process Gland Morphogenesis Autophagy Epidermal Growth Factor Receptor Signaling Pathway Response To Corticosteroid ERBB Signaling Pathway
Tagcloud ?		2000mug 3f aminobutyric anabolism atg12 atg13 atg5 atrogin atrogin1 autophagosome beta2 bnip3 culminated e1b eb eif3 formoterol hydrolases kinase1 lc3b mafbx myod protein3 relativized sqstm1 tfeb tibialis ulk1 unc	atypical autonomous autonomously biogenesis consequently coordinates delay dilp dilps drosophila effector epistatically erk7 erk8 humoral impede ipcs larval limiting neurosecretory nutrient nutrition operates ribosome secreting secretion starvation surveillance uncover
Tagcloud (Difference) ?		2000mug 3f aminobutyric anabolism atg12 atg13 atg5 atrogin atrogin1 autophagosome beta2 bnip3 culminated e1b eb eif3 formoterol hydrolases kinase1 lc3b mafbx myod protein3 relativized sqstm1 tfeb tibialis ulk1 unc	atypical autonomous autonomously biogenesis consequently coordinates delay dilp dilps drosophila effector epistatically erk7 erk8 humoral impede ipcs larval limiting neurosecretory nutrient nutrition operates ribosome secreting secretion starvation surveillance uncover
Tagcloud (Intersection) ?