GABARAPL1 and ATG4B

Number of citations of the paper that reports this interaction (PMID 20562859)
242

Data Source:
BioGRID (enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study)

		GABARAPL1	ATG4B
Gene Name		GABA(A) receptor-associated protein like 1	autophagy related 4B, cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Autophagic Vacuole Membrane Intracellular Autophagic Vacuole Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Dendrite Membrane Dendrite Cytoplasm Cell Body	Cytoplasm Cytosol
	Molecular Function	Protein Binding Microtubule Binding Tat Protein Binding Beta-tubulin Binding GABA Receptor Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation Nucleophagy Membrane Fusion	Autophagic Vacuole Assembly Mitochondrion Degradation C-terminal Protein Lipidation Proteolysis Protein Targeting To Membrane Autophagy Cellular Response To Nitrogen Starvation Positive Regulation Of Autophagy Protein Processing Nucleophagy Positive Regulation Of Protein Catabolic Process Protein Delipidation
Pathways
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		35 interactors: AHNAK2 ATG4A ATG4B ATG4D CALCOCO2 DVL2 FAM134C FUNDC1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 MAPK15 OPRK1 RABGAP1 RABGAP1L SCYL3 SNCA SQSTM1 SRPK1 SRPK2 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TNIP1 VDR	6 interactors: GABARAP GABARAPL1 GABARAPL2 LINC00341 MAP1LC3A MAP1LC3B
Entrez ID		23710	23192
HPRD ID		07601	16499
Ensembl ID		ENSG00000139112	ENSG00000168397
Uniprot IDs		Q9H0R8	B3KVU2 F5H7P2 F8WD71 Q9Y4P1
PDB IDs		2L8J 2R2Q	2CY7 2D1I 2Z0D 2Z0E 2ZZP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Positive Regulation Of Ras GTPase Activity Regulation Of Ras Protein Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Autophagy Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Signaling Protein Delipidation Mitochondrion Degradation Organelle Disassembly Regulation Of Metabolic Process Macroautophagy Cellular Response To Nitrogen Starvation Retrograde Transport, Endosome To Golgi Cellular Response To Nutrient Levels Nucleophagy Response To Starvation C-terminal Protein Lipidation Endosomal Transport Cellular Response To Extracellular Stimulus Protein Processing Response To Nutrient Levels Positive Regulation Of Autophagy Response To Extracellular Stimulus Autophagic Vacuole Assembly Cellular Response To Starvation Negative Regulation Of Viral Genome Replication Regulation Of Viral Genome Replication Mitochondrion Organization Negative Regulation Of Viral Process Vacuole Organization Regulation Of Autophagy Positive Regulation Of Viral Genome Replication Protein Lipidation Intracellular Transport Lipoprotein Biosynthetic Process Cellular Localization Response To Stress Establishment Of Localization In Cell Positive Regulation Of Protein Metabolic Process	Nucleophagy Mitochondrion Degradation Organelle Disassembly Autophagic Vacuole Assembly Macroautophagy Vacuole Organization Membrane Fusion Cellular Response To Starvation Autophagy Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Mitochondrion Organization Response To Nutrient Levels Cellular Response To Nitrogen Starvation Response To Extracellular Stimulus Organelle Assembly Membrane Organization Cellular Response To Stress Catabolic Process Response To External Stimulus Cellular Component Assembly Organelle Organization Response To Stress Cell Communication Cellular Response To Stimulus Response To Stimulus Positive Regulation Of ATPase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of ATPase Activity Intra-Golgi Vesicle-mediated Transport Negative Regulation Of Proteasomal Protein Catabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Protein Catabolic Process Extrinsic Apoptotic Signaling Pathway
Tagcloud ?		2000mug 3f aminobutyric anabolism atg12 atg13 atg5 atrogin atrogin1 autophagosome beta2 bnip3 culminated e1b eb eif3 formoterol hydrolases kinase1 lc3b mafbx myod protein3 relativized sqstm1 tfeb tibialis ulk1 unc	akt1 antipsychotic atg12 atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		2000mug 3f aminobutyric anabolism atg13 atrogin atrogin1 beta2 bnip3 culminated e1b eb eif3 formoterol hydrolases kinase1 mafbx myod protein3 relativized tfeb tibialis ulk1 unc	akt1 antipsychotic atg7 autophagic autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth map1lc3b olanzapine overtly pmaip1 sy5y trp53 unmask
Tagcloud (Intersection) ?		atg12 atg5 autophagosome lc3b sqstm1