GABARAPL1 and TBC1D5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, pull down)

		GABARAPL1	TBC1D5
Description		GABA type A receptor associated protein like 1	TBC1 domain family member 5
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GO Annotations	Cellular Component	Autophagosome Membrane Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ciliary Basal Body	Cytoplasm Endosome Autophagosome Golgi Apparatus Cytosol Endosome Membrane Membrane AP-2 Adaptor Complex Retromer Complex Cytoplasmic Vesicle Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Binding Phospholipid Binding Phosphatidylethanolamine Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	GTPase Activator Activity Protein Binding AP-2 Adaptor Complex Binding Protein-containing Complex Binding Retromer Complex Binding
	Biological Process	Autophagosome Assembly Mitophagy Autophagy Cellular Response To Nitrogen Starvation Glycophagy Autophagosome Maturation	Positive Regulation Of Receptor Internalization Autophagy Protein Transport Macroautophagy Retrograde Transport, Endosome To Golgi Response To Starvation Regulation Of Cilium Assembly
Pathways		Macroautophagy
Drugs
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Aspartate aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Language functional connectivity ( 34929384) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Parkinson's disease ( 32201043) Platelet count ( 32888494 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252 32888494) Schizophrenia ( 29483656 28991256 25056061) Self-reported risk-taking behaviour ( 30271922) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		87 interacting genes: AHNAK2 AMBRA1 ANK2 APPL1 ARFGAP1 ATG13 ATG4A ATG4B ATG4D AZI2 BICC1 BNIP3L BRD9 BSCL2 BSDC1 CALCOCO1 CALCOCO2 CARS2 CCT2 CDC37 CREB3L2 CUL3 DISC1 DVL2 DYNLL1 ERBB2 ERBB3 FUNDC1 G3BP1 KBTBD7 KRTAP10-3 KRTAP10-7 KRTAP10-9 KXD1 MAP4K2 MAPK15 MEFV MLX MYBPC1 NCOR1 NEDD4 NFIA NUFIP2 OPRK1 OPTN OSBPL3 PBXIP1 PSMB4 PTPRR RABGAP1 RABGAP1L RB1CC1 RCN2 RESF1 RETREG3 SCYL3 SEC62 SNCA SQSTM1 SRPK1 SRPK2 STK3 STRN3 TAX1BP1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B THAP7 TMEM131 TNIP1 TP53INP1 TRIM21 TRIM25 TRIM32 UMAD1 VDR WDFY3 ZBTB22	11 interacting genes: AP2M1 ATXN1 CHIA EIF1AD FBXL7 GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B UBC ZBTB25
Entrez ID		23710	9779
HPRD ID		07601	10262
Ensembl ID		ENSG00000139112	ENSG00000131374
Uniprot IDs		Q9H0R8	B9A6K1 Q92609
PDB IDs		2L8J 2R2Q 5DPT 5LXH 5LXI 6HOI 6HOL 6YOO 7AA7 7AA9 7JHX 8X8A	5GTU
Enriched GO Terms of Interacting Partners?		Autophagosome Regulation Of Cilium Assembly Autophagy Macroautophagy GTPase Activator Activity Regulation Of Organelle Assembly Cytosol Regulation Of Autophagy Positive Regulation Of Autophagy Autophagy Of Mitochondrion Regulation Of Cell Projection Assembly Mitophagy Autophagosome Assembly Autophagosome Organization Aggrephagy Cytoplasmic Vesicle Piecemeal Microautophagy Of The Nucleus Cytoplasm Regulation Of Cell Projection Organization Microautophagy Nucleophagy Positive Regulation Of Catabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Vacuole Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Protein-phosphatidylethanolamide Deconjugating Activity Catabolic Process Protein Delipidation Response To Mitochondrial Depolarisation Organelle Assembly Regulation Of Macroautophagy Atg1/ULK1 Kinase Complex Regulation Of Cellular Component Organization Positive Regulation Of Macroautophagy Regulation Of Intracellular Signal Transduction Protein Polyubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Signal Transduction Phagophore Assembly Site Negative Regulation Of Signal Transduction ERBB3:ERBB2 Complex Protein Localization To Phagocytic Vesicle Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Viral Process	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Ubiquitin Protein Ligase Binding Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Autophagy Catabolic Process GABA Receptor Binding Cytoplasmic Vesicle Polysaccharide Catabolic Process Response To Nutrient Levels Beta-tubulin Binding Organelle Membrane Microtubule Binding Organelle Assembly Cytosol Polysaccharide Metabolic Process Endocytic Vesicle Membrane Protein-containing Complex Organization Microtubule Endochitinase Activity Signal Sequence Binding POZ Domain Binding Carbohydrate Catabolic Process Polysaccharide Digestion Cellular Response To Oxygen-glucose Deprivation Extrinsic Component Of Presynaptic Endocytic Zone Membrane Macromolecule Catabolic Process Chitin Metabolic Process Chitin Catabolic Process Chitinase Activity Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Chitin Binding Response To Iron(II) Ion Postsynaptic Neurotransmitter Receptor Internalization Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
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