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CDKN2A and E2F1
Number of citations of the paper that reports this interaction (PubMedID
20106982
)
62
Data Source:
BioGRID
(imaging technique)
HPRD
(in vitro)
CDKN2A
E2F1
Description
cyclin dependent kinase inhibitor 2A
E2F transcription factor 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Nuclear Body
Protein-containing Complex
Senescence-associated Heterochromatin Focus
Nuclear Chromosome
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Protein-containing Complex
Rb-E2F Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
P53 Binding
DNA Binding
RNA Binding
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
SUMO Transferase Activity
Protein Kinase Binding
NF-kappaB Binding
Ligase Inhibitor Activity
Ubiquitin-protein Transferase Inhibitor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
MDM2/MDM4 Family Protein Binding
Disordered Domain Specific Binding
Ubiquitin Ligase Inhibitor Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Kinase Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
Molecular Adaptor Activity
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Autophagy Of Mitochondrion
Negative Regulation Of Cell-matrix Adhesion
RRNA Processing
Apoptotic Process
Ras Protein Signal Transduction
Negative Regulation Of Cell Population Proliferation
Epidermis Development
RRNA Transcription
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Protein Sumoylation
Keratinocyte Differentiation
Negative Regulation Of Cell Growth
Nuclear Body Organization
Negative Regulation Of B Cell Proliferation
Regulation Of Protein Stability
Protein Destabilization
Negative Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Protein Sumoylation
Mammary Gland Epithelial Cell Proliferation
Negative Regulation Of Mammary Gland Epithelial Cell Proliferation
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Protein Localization To Nucleus
Somatic Stem Cell Population Maintenance
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Keratinocyte Proliferation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleocytoplasmic Transport
Regulation Of Protein Export From Nucleus
Somatic Stem Cell Division
Protein Stabilization
Regulation Of Cell Cycle
Mitochondrial Depolarization
Apoptotic Process Involved In Mammary Gland Involution
Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Cellular Response To Hydrogen Peroxide
Protein K63-linked Ubiquitination
Cellular Senescence
Replicative Senescence
Oncogene-induced Cell Senescence
Apoptotic Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Signal Transduction By P53 Class Mediator
Protein Localization To Nucleolus
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Ubiquitin Protein Ligase Activity
Amyloid Fibril Formation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macrophage Apoptotic Process
Negative Regulation Of Protein Neddylation
DNA Damage Checkpoint Signaling
Negative Regulation Of Transcription By RNA Polymerase II
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Gene Expression
Forebrain Development
Response To Lipopolysaccharide
Positive Regulation Of Apoptotic Process
Anoikis
Negative Regulation Of DNA Binding
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
MRNA Stabilization
Regulation Of Cell Cycle
Positive Regulation Of Glial Cell Proliferation
Negative Regulation Of Fat Cell Proliferation
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Lens Fiber Cell Apoptotic Process
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1
Transcriptional Regulation by VENTX
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Apoptotic factor-mediated response
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
Regulation of TP53 Degradation
Stabilization of p53
Regulation of RUNX3 expression and activity
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
Evasion of Oncogene Induced Senescence Due to p14ARF Defects
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects
Nuclear events mediated by NFE2L2
Activation of NOXA and translocation to mitochondria
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Activation of PUMA and translocation to mitochondria
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
G2 Phase
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by E2F6
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
Chronic myeloid leukemia (CML)
Non-small cell lung cancer
Malignant islet cell carcinoma
Adult T-cell leukemia
Esophageal cancer
Glioma
Pancreatic cancer
Nasopharyngeal cancer
Hepatocellular carcinoma
Squamous cell carcinoma
Penile cancer
Oral cancer
Malignant melanoma
Burkitt lymphoma
Gallbladder cancer
Bladder cancer
Laryngeal cancer
Cholangiocarcinoma
Malignant pleural mesothelioma
Osteosarcoma
Type II diabetes mellitus
GWAS
Abdominal aortic aneurysm (
20622881
)
Acute lymphoblastic leukemia (childhood) (
29348612
)
Acute lymphoblastic leukemia in childhood (B cell precursor) (
29632299
)
B-cell acute lymphoblastic leukaemia (
31767839
)
Basal cell carcinoma (
25855136
24403052
)
Basophil count (
32888494
)
Breast cancer (
23535729
29059683
20453838
)
Coronary artery calcification (
23561647
)
Coronary artery disease (
29263402
26708285
21239051
)
Coronary heart disease (
21971053
21378990
17554300
)
Coronary heart disease (SNP X SNP interaction) (
21626137
)
Coronary heart disease x type 2 diabetes interaction (
32541925
)
Endometrial cancer (
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Endometriosis (
23104006
)
Eosinophil count (
32888494
)
Esophageal squamous cell carcinoma (
25129146
)
Fasting plasma glucose (
25187374
)
Glioblastoma (
28346443
)
Glioma (
21531791
28346443
19578367
)
Inflammatory bowel disease (
27569725
)
Intracranial aneurysm (
18997786
20364137
)
Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) (
27418160
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Melanoma (
28212542
19578364
21983787
)
Monocyte count (
27863252
32888494
)
Multiple myeloma (
27363682
)
Myocardial infarction (
17478679
26708285
)
Myocardial infarction (early onset) (
19198609
)
Nasopharyngeal carcinoma (
26545403
)
Neutrophil percentage of white cells (
32888494
)
Non-glioblastoma glioma (
28346443
)
Non-small cell lung cancer (
31326317
)
Parental longevity (both parents in top 10%) (
29227965
)
Parental longevity (father's age at death) (
29227965
)
Platelet count (
27863252
22139419
32888494
)
Plateletcrit (
27863252
32888494
)
Red cell distribution width (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Spleen volume (
34128465
)
Type 2 diabetes (
23209189
17463246
17463248
17463249
18372903
19401414
20581827
21573907
30718926
23945395
24509480
26818947
26961502
27189021
32499647
29358691
30297969
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
White blood cell count (
27863252
32888494
)
Heel bone mineral density (
30598549
)
Height (
31562340
)
Waist circumference adjusted for body mass index (
34021172
)
Interacting Genes
168 interacting genes:
-
ACLY
ACTB
ACTG1
ACTN4
AHNAK
AKT1
ALDOB
ANAPC15
ANGPTL4
ANKRA2
ANKRD12
AOPEP
ARFIP2
ARNT
ASPRV1
AZIN1
BAAT
BCL2L1
BECN1
CARF
CASC3
CCDC180
CCDC183
CCND2
CCNDBP1
CCNE1
CCNG1
CD44
CDC14B
CDC42
CDC45
CDC5L
CDC6
CDC7
CDK4
CDK6
CDKN2AIP
CDKN2C
CENPA
CRELD2
CTBP2
CTSV
CYLC2
DEAF1
E2F1
E4F1
EEF2
EFHC2
EGR1
EPHA2
EPHA3
EXOC2
FGFR4
FN1
FRAT2
GALNT12
GAPDH
GGA1
GGA3
GLIS1
GLIS2
GMNN
GSPT1
H2BC26
HGF
HIF1A
HLA-DOB
HNRNPA2B1
HNRNPC
HNRNPU
HRAS
HSP90AA1
HSP90AB1
HSPA4
HSPA8
HUWE1
ISOC2
KAT5
LATS2
MAF1
MAP2K1
MAP2K5
MAP3K5
MAPK10
MAPK14
MAPK3
MAPK8
MCM10
MCM2
MCM5
MCM6
MDM2
MDM4
MKRN1
MMRN1
MTR
MYC
MYL12A
NAT2
NCL
NMI
NOP53
NPM1
NSD3
ORC4
PCNA
PDCD6
PDGFRA
PEX19
PPP1R9B
PRKCA
PSMC3
PTP4A3
RAF1
RASA1
RASSF1
RBM26
RIN2
RPL11
RPS7
RUVBL2
SEC61B
SERTAD1
SFRP4
SGK1
SIVA1
SIX2
SLC4A1
SMARCA4
SNRPA
SNRPB
SOX3
SOX4
STK11
TBRG1
TDRD7
TEAD2
TERT
TFDP1
TGFB1
TMEFF1
TMOD1
TP63
TPI1
TRIM28
TRIP12
TSC1
TUBA1A
TUBA1C
TUBB
TUBB4B
UBC
UBE2A
UBE4B
UBL7
USP26
VAMP1
VHL
WRN
YY1
ZFP91
ZGRF1
ZNF227
ZNF410
ZNF420
ZNF687
ZUP1
83 interacting genes:
ARID3A
ATAD2
ATM
ATR
BIN1
BIRC2
BRCA1
BRD2
BRMS1
BTRC
CCNA1
CCNA2
CCNF
CDK1
CDK2
CDK3
CDK7
CDKN2A
CEBPE
CHEK2
CREBBP
CTDP1
CUL1
CUL2
DDB2
DIABLO
E2F6
EP300
ERCC3
FHL2
GSK3B
GTF2H1
HCFC1
IGF1
KAT5
KDM1A
MDM4
MGA
MNAT1
MTA1
MYBL2
NCOA3
NCOA6
NCOR2
NDN
NFKB1
NPDC1
NRIP1
NSMCE3
PARP1
PHB1
PKIB
PRDM2
PURA
RARA
RB1
RBL1
RNF126
RNF144A
SERTAD2
SETD7
SIRT1
SKP2
SP1
SP2
SP3
SP4
SPIB
STAT1
STOML1
SZRD1P1
TBP
TEAD3
TFDP1
TFDP2
TOPBP1
TP53
TP53BP1
TRRAP
UBE3A
UCHL5
VHL
YWHAQ
Entrez ID
1029
1869
HPRD ID
02542
01806
Ensembl ID
ENSG00000147889
ENSG00000101412
Uniprot IDs
K7PML8
P42771
Q8N726
Q01094
Q9BSD8
PDB IDs
1A5E
1BI7
1DC2
2A5E
7OZT
1H24
1O9K
2AZE
5M9N
5M9O
6G0P
6ULS
9CB3
Enriched GO Terms of Interacting Partners
?
Nucleus
Nucleoplasm
Cellular Response To Stress
Regulation Of Cell Cycle
Regulation Of Primary Metabolic Process
DNA Damage Response
Regulation Of Cell Population Proliferation
Response To Stress
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Protein Stability
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Metabolic Process
Cytosol
Regulation Of DNA Metabolic Process
Regulation Of Protein Metabolic Process
Response To Radiation
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Replication Initiation
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Mitotic Cell Cycle
DNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Nucleotide Binding
Regulation Of Cellular Component Organization
Macromolecule Metabolic Process
Protein-containing Complex
Negative Regulation Of Macromolecule Metabolic Process
Cellular Senescence
ATP Binding
Positive Regulation Of Cell Cycle Process
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Catalytic Activity
Cellular Response To Radiation
Positive Regulation Of Transcription By RNA Polymerase II
Nucleic Acid Metabolic Process
Positive Regulation Of Cell Cycle Phase Transition
Protein Stabilization
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of Fibroblast Proliferation
Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Nucleus
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Cell Cycle
Negative Regulation Of RNA Metabolic Process
Chromatin Organization
DNA Damage Response
Chromatin Remodeling
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Repair
G1/S Transition Of Mitotic Cell Cycle
DNA Metabolic Process
Cell Cycle G1/S Phase Transition
Chromatin
Cellular Response To Stress
Regulation Of DNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Transcription Regulator Complex
Negative Regulation Of Macromolecule Biosynthetic Process
Nucleic Acid Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Apoptotic Process
Protein Localization To Site Of Double-strand Break
Positive Regulation Of DNA Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Programmed Cell Death
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