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CDKN2A and USP26
Number of citations of the paper that reports this interaction (PMID
17955473
)
10
Data Source:
BioGRID
(pull down)
CDKN2A
USP26
Gene Name
cyclin-dependent kinase inhibitor 2A
ubiquitin specific peptidase 26
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Nuclear Body
Senescence-associated Heterochromatin Focus
Protein Complex
Nucleus
Molecular Function
P53 Binding
DNA Binding
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Poly(A) RNA Binding
NF-kappaB Binding
Ubiquitin-protein Transferase Inhibitor Activity
MDM2/MDM4 Family Protein Binding
Cysteine-type Endopeptidase Activity
Ubiquitin-specific Protease Activity
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Negative Regulation Of Cell-matrix Adhesion
Transcription, DNA-templated
RRNA Processing
Negative Regulation Of Protein Kinase Activity
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Cycle Arrest
Ras Protein Signal Transduction
Negative Regulation Of Cell Proliferation
Apoptotic Mitochondrial Changes
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Growth
Negative Regulation Of B Cell Proliferation
Regulation Of Protein Stability
Protein Destabilization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Protein Sumoylation
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Senescence-associated Heterochromatin Focus Assembly
Negative Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Protein Export From Nucleus
Somatic Stem Cell Division
Protein Stabilization
Negative Regulation Of Ubiquitin-protein Transferase Activity
Protein K63-linked Ubiquitination
Positive Regulation Of Cell Cycle Arrest
Cellular Senescence
Replicative Senescence
Regulation Of Apoptotic DNA Fragmentation
Positive Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Cellular Senescence
Protein Deubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Pathways
Cyclin D associated events in G1
Oxidative Stress Induced Senescence
G1 Phase
Cellular Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Mitotic G1-G1/S phases
Cell Cycle, Mitotic
Oxidative Stress Induced Senescence
Cellular Senescence
Oncogene Induced Senescence
Drugs
Diseases
GWAS
Abdominal aortic aneurysm (
20622881
)
Breast cancer (
23535729
20453838
)
Coronary artery calcification (
23561647
)
Coronary heart disease (
21626137
21971053
17554300
21378990
)
Endometriosis (
23104006
)
Glioma (
21531791
19578367
)
Intracranial aneurysm (
18997786
20364137
)
Melanoma (
21983787
19578364
)
Myocardial infarction (
17478679
)
Myocardial infarction (early onset) (
19198609
)
Platelet counts (
22139419
)
Type 2 diabetes (
21573907
18372903
20581827
19401414
17463246
17463248
17463249
23209189
)
Protein-Protein Interactions
94 interactors:
ACLY
ACTB
ACTG1
ACTN4
AHNAK
ANKRD12
ARFIP2
BCL2L1
BECN1
CARF
CCDC183
CCND1
CCND2
CCNG1
CDC45
CDC5L
CDC6
CDC7
CDK4
CDK6
CDKN2AIP
CDKN2C
CRELD2
CTBP2
DEAF1
E2F1
E4F1
EEF2
EGR1
EPHA3
FN1
GAPDH
GGA1
GGA3
GMNN
GSPT1
HIF1A
HIST3H2BB
HNRNPA2B1
HNRNPC
HNRNPU
HSP90AA1
HSP90AB1
HSPA4
HSPA8
HUWE1
KAT5
MAPK10
MAPK8
MCM10
MCM2
MCM5
MCM6
MDM2
MMRN1
MTR
MYC
MYL12A
NCL
NMI
ORC4
PCNA
PDCD6
PEX19
PLEKHA8
PPP1R9B
PRKCA
PSMC3
RIN2
RPS7
RUVBL2
SERTAD1
SIVA1
SLC4A1
SMARCA4
SNRPA
SNRPB
TBRG1
TDRD7
TP63
TPI1
TRIP12
TUBA1A
TUBA1C
TUBB
TUBB4B
UBE2A
UBE4B
USP26
WRN
YY1
ZFP91
ZNF227
ZNF410
1 interactors:
CDKN2A
Entrez ID
1029
83844
HPRD ID
02542
02255
Ensembl ID
ENSG00000147889
ENSG00000134588
Uniprot IDs
G3XAG3
K7PML8
P42771
Q8N726
Q9BXU7
PDB IDs
1A5E
1BI7
1DC2
2A5E
Enriched GO Terms of Interacting Partners
?
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cell Cycle Process
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Response To Stress
Cellular Response To Stress
Regulation Of Metabolic Process
Regulation Of Cell Cycle
Response To Abiotic Stimulus
Cellular Response To DNA Damage Stimulus
Response To Radiation
Negative Regulation Of Cell Cycle
Response To Light Stimulus
Regulation Of Mitotic Cell Cycle
Cell Division
Cellular Nitrogen Compound Metabolic Process
Response To UV
Positive Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Organelle Organization
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Replication
DNA Replication Initiation
Nitrogen Compound Metabolic Process
Chromosome Organization
Cellular Metabolic Process
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Cellular Metabolic Process
DNA Metabolic Process
Positive Regulation Of Cell Cycle Phase Transition
Cellular Response To Radiation
Regulation Of Protein Metabolic Process
DNA-dependent DNA Replication
Regulation Of Mitotic Cell Cycle Phase Transition
Cell Cycle Checkpoint
Regulation Of Cell Proliferation
Cellular Macromolecule Biosynthetic Process
Regulation Of Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Macromolecule Biosynthetic Process
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Response To Stimulus
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Senescence-associated Heterochromatin Focus Assembly
Positive Regulation Of Cellular Senescence
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Negative Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Macrophage Apoptotic Process
Regulation Of Apoptotic DNA Fragmentation
Positive Regulation Of Cell Aging
Positive Regulation Of Myeloid Cell Apoptotic Process
Negative Regulation Of T Cell Differentiation In Thymus
Heterochromatin Assembly
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Protein Sumoylation
Regulation Of Smooth Muscle Cell Apoptotic Process
Heterochromatin Organization
Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Signal Transduction By P53 Class Mediator
Replicative Senescence
Negative Regulation Of B Cell Proliferation
Regulation Of Protein Sumoylation
Protein Destabilization
Regulation Of Cellular Senescence
Regulation Of Execution Phase Of Apoptosis
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Somatic Stem Cell Division
Cellular Senescence
Regulation Of Protein Export From Nucleus
Regulation Of T Cell Differentiation In Thymus
Positive Regulation Of Leukocyte Apoptotic Process
Protein K63-linked Ubiquitination
Negative Regulation Of T Cell Differentiation
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of B Cell Activation
Regulation Of Myeloid Cell Apoptotic Process
Stem Cell Division
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Lymphocyte Differentiation
Negative Regulation Of Cell-substrate Adhesion
Regulation Of Muscle Cell Apoptotic Process
Regulation Of B Cell Proliferation
Negative Regulation Of T Cell Proliferation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Response To DNA Damage Stimulus
Cell Aging
Apoptotic Mitochondrial Changes
Negative Regulation Of Lymphocyte Proliferation
Negative Regulation Of Mononuclear Cell Proliferation
Tagcloud
?
a134c
abp
allelic
ankyrin
balb
cdk6
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Difference)
?
a134c
abp
allelic
ankyrin
balb
cdk6
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Intersection)
?