CDKN2A and TUBA1A

Number of citations of the paper that reports this interaction (PubMedID 17955473)
0

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BioGRID (pull down)

		CDKN2A	TUBA1A
Description		cyclin dependent kinase inhibitor 2A	tubulin alpha 1a
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Nuclear Body Protein-containing Complex Senescence-associated Heterochromatin Focus	Condensed Chromosome Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Axonemal Microtubule Cytoplasmic Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Motile Cilium Neuromuscular Junction Sperm Flagellum Cytoplasmic Ribonucleoprotein Granule Cell Projection Synapse Recycling Endosome Extracellular Exosome
	Molecular Function	P53 Binding DNA Binding RNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SUMO Transferase Activity Protein Kinase Binding NF-kappaB Binding Ligase Inhibitor Activity Ubiquitin-protein Transferase Inhibitor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding MDM2/MDM4 Family Protein Binding Disordered Domain Specific Binding Ubiquitin Ligase Inhibitor Activity	Nucleotide Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Hydrolase Activity Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Autophagy Of Mitochondrion Negative Regulation Of Cell-matrix Adhesion RRNA Processing Apoptotic Process Ras Protein Signal Transduction Negative Regulation Of Cell Population Proliferation Epidermis Development RRNA Transcription Regulation Of Gene Expression Positive Regulation Of Gene Expression Protein Sumoylation Keratinocyte Differentiation Negative Regulation Of Cell Growth Nuclear Body Organization Negative Regulation Of B Cell Proliferation Regulation Of Protein Stability Protein Destabilization Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Protein Sumoylation Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Protein Localization To Nucleus Somatic Stem Cell Population Maintenance Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Keratinocyte Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Export From Nucleus Somatic Stem Cell Division Protein Stabilization Regulation Of Cell Cycle Mitochondrial Depolarization Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Cellular Response To Hydrogen Peroxide Protein K63-linked Ubiquitination Cellular Senescence Replicative Senescence Oncogene-induced Cell Senescence Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction By P53 Class Mediator Protein Localization To Nucleolus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Ubiquitin Protein Ligase Activity Amyloid Fibril Formation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macrophage Apoptotic Process Negative Regulation Of Protein Neddylation	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Startle Response Intracellular Protein Transport Microtubule-based Process Centrosome Cycle Smoothened Signaling Pathway Memory Locomotory Behavior Adult Locomotory Behavior Visual Learning Response To Mechanical Stimulus Glial Cell Differentiation Gene Expression Dentate Gyrus Development Cerebellar Cortex Morphogenesis Hippocampus Development Pyramidal Neuron Differentiation Cerebral Cortex Development Neurogenesis Neuron Differentiation Flagellated Sperm Motility Adult Behavior Cytoskeleton-dependent Intracellular Transport Response To Tumor Necrosis Factor Locomotory Exploration Behavior Microtubule Polymerization Forebrain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Regulation Of Synapse Organization Synapse Organization Cell Division Neuron Apoptotic Process Motor Behavior Cellular Response To Calcium Ion Organelle Transport Along Microtubule Neuron Projection Arborization Response To L-glutamate
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1 Transcriptional Regulation by VENTX Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Apoptotic factor-mediated response Oxidative Stress Induced Senescence Oncogene Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors Regulation of TP53 Degradation Stabilization of p53 Regulation of RUNX3 expression and activity Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function Evasion of Oncogene Induced Senescence Due to p14ARF Defects Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects Nuclear events mediated by NFE2L2	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs			Albendazole Vinblastine Mebendazole Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Artenimol Phenethyl Isothiocyanate Colchiceine
Diseases		Chronic myeloid leukemia (CML) Non-small cell lung cancer Malignant islet cell carcinoma Adult T-cell leukemia Esophageal cancer Glioma Pancreatic cancer Nasopharyngeal cancer Hepatocellular carcinoma Squamous cell carcinoma Penile cancer Oral cancer Malignant melanoma Burkitt lymphoma Gallbladder cancer Bladder cancer Laryngeal cancer Cholangiocarcinoma Malignant pleural mesothelioma Osteosarcoma Type II diabetes mellitus	Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Abdominal aortic aneurysm ( 20622881) Acute lymphoblastic leukemia (childhood) ( 29348612) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Basal cell carcinoma ( 25855136 24403052) Basophil count ( 32888494) Breast cancer ( 23535729 29059683 20453838) Coronary artery calcification ( 23561647) Coronary artery disease ( 29263402 26708285 21239051) Coronary heart disease ( 21971053 21378990 17554300) Coronary heart disease (SNP X SNP interaction) ( 21626137) Coronary heart disease x type 2 diabetes interaction ( 32541925) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Endometriosis ( 23104006) Eosinophil count ( 32888494) Esophageal squamous cell carcinoma ( 25129146) Fasting plasma glucose ( 25187374) Glioblastoma ( 28346443) Glioma ( 21531791 28346443 19578367) Inflammatory bowel disease ( 27569725) Intracranial aneurysm ( 18997786 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Melanoma ( 28212542 19578364 21983787) Monocyte count ( 27863252 32888494) Multiple myeloma ( 27363682) Myocardial infarction ( 17478679 26708285) Myocardial infarction (early onset) ( 19198609) Nasopharyngeal carcinoma ( 26545403) Neutrophil percentage of white cells ( 32888494) Non-glioblastoma glioma ( 28346443) Non-small cell lung cancer ( 31326317) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (father's age at death) ( 29227965) Platelet count ( 27863252 22139419 32888494) Plateletcrit ( 27863252 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spleen volume ( 34128465) Type 2 diabetes ( 23209189 17463246 17463248 17463249 18372903 19401414 20581827 21573907 30718926 23945395 24509480 26818947 26961502 27189021 32499647 29358691 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252 32888494)	Brain morphology (MOSTest) ( 32665545) Composite immunoglobulin trait (IgG/IgM) ( 28628107)
Interacting Genes		168 interacting genes: - ACLY ACTB ACTG1 ACTN4 AHNAK AKT1 ALDOB ANAPC15 ANGPTL4 ANKRA2 ANKRD12 AOPEP ARFIP2 ARNT ASPRV1 AZIN1 BAAT BCL2L1 BECN1 CARF CASC3 CCDC180 CCDC183 CCND2 CCNDBP1 CCNE1 CCNG1 CD44 CDC14B CDC42 CDC45 CDC5L CDC6 CDC7 CDK4 CDK6 CDKN2AIP CDKN2C CENPA CRELD2 CTBP2 CTSV CYLC2 DEAF1 E2F1 E4F1 EEF2 EFHC2 EGR1 EPHA2 EPHA3 EXOC2 FGFR4 FN1 FRAT2 GALNT12 GAPDH GGA1 GGA3 GLIS1 GLIS2 GMNN GSPT1 H2BC26 HGF HIF1A HLA-DOB HNRNPA2B1 HNRNPC HNRNPU HRAS HSP90AA1 HSP90AB1 HSPA4 HSPA8 HUWE1 ISOC2 KAT5 LATS2 MAF1 MAP2K1 MAP2K5 MAP3K5 MAPK10 MAPK14 MAPK3 MAPK8 MCM10 MCM2 MCM5 MCM6 MDM2 MDM4 MKRN1 MMRN1 MTR MYC MYL12A NAT2 NCL NMI NOP53 NPM1 NSD3 ORC4 PCNA PDCD6 PDGFRA PEX19 PPP1R9B PRKCA PSMC3 PTP4A3 RAF1 RASA1 RASSF1 RBM26 RIN2 RPL11 RPS7 RUVBL2 SEC61B SERTAD1 SFRP4 SGK1 SIVA1 SIX2 SLC4A1 SMARCA4 SNRPA SNRPB SOX3 SOX4 STK11 TBRG1 TDRD7 TEAD2 TERT TFDP1 TGFB1 TMEFF1 TMOD1 TP63 TPI1 TRIM28 TRIP12 TSC1 TUBA1A TUBA1C TUBB TUBB4B UBC UBE2A UBE4B UBL7 USP26 VAMP1 VHL WRN YY1 ZFP91 ZGRF1 ZNF227 ZNF410 ZNF420 ZNF687 ZUP1	66 interacting genes: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CEP20 CLIP1 CNP CPEB2 CXCR1 CYLD DAG1 DUSP23 EGFR EIF4ENIF1 EML1 ENO1 GEMIN7 GRM7 GSK3B GZMB HTRA2 KEL KPNB1 LINC01554 LRRK2 MAP7D3 MAPK6 MAPRE1 MAX MX1 MYC NFATC1 NUDT3 OGT PAFAH1B1 PGK1 PLA2G7 PLK2 S100A8 S100A9 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPART STARD13 STK11 SYK SYTL4 TAOK2 TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70
Entrez ID		1029	7846
HPRD ID		02542	03959
Ensembl ID		ENSG00000147889	ENSG00000167552
Uniprot IDs		K7PML8 P42771 Q8N726	Q71U36
PDB IDs		1A5E 1BI7 1DC2 2A5E 7OZT	5JCO 6J8F 6WSL 7C1M 7UN1 7UNG 8J07 8SH7
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Cellular Response To Stress Regulation Of Cell Cycle Regulation Of Primary Metabolic Process DNA Damage Response Regulation Of Cell Population Proliferation Response To Stress Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Protein Stability Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Metabolic Process Cytosol Regulation Of DNA Metabolic Process Regulation Of Protein Metabolic Process Response To Radiation Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Replication Initiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle DNA Metabolic Process Positive Regulation Of Biosynthetic Process Nucleotide Binding Regulation Of Cellular Component Organization Macromolecule Metabolic Process Protein-containing Complex Negative Regulation Of Macromolecule Metabolic Process Cellular Senescence ATP Binding Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Catalytic Activity Cellular Response To Radiation Positive Regulation Of Transcription By RNA Polymerase II Nucleic Acid Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of DNA Metabolic Process Positive Regulation Of Fibroblast Proliferation Nucleobase-containing Compound Metabolic Process	Cytoplasm Cytosol Regulation Of Cell Growth Intracellular Signaling Cassette Microtubule Binding Regulation Of Growth Microtubule Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Cellular Component Organization Organelle Organization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Programmed Cell Death Protein-containing Complex Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cytoskeleton Positive Regulation Of Cell Communication Regulation Of Cell Communication Kinase Activity Positive Regulation Of Signaling Regulation Of Signaling Protein Metabolic Process Regulation Of Developmental Process Regulation Of Intrinsic Apoptotic Signaling Pathway Myeloid Leukocyte Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Cell Migration Neutrophil Chemotaxis Developmental Process Cytoplasmic Microtubule Microtubule-based Process Ubiquitin Protein Ligase Binding Catabolic Process Leukocyte Migration Protein Serine/threonine Kinase Activity Protein Kinase Activity Tubulin Binding Negative Regulation Of Cell Growth Cytoskeleton Organization Neutrophil Migration Protein Localization To Nucleus Cellular Developmental Process Microtubule Cytoskeleton Microtubule Positive Regulation Of Apoptotic Process Leukocyte Aggregation Regulation Of Microtubule-based Process
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