CDKN2A and ACLY

Number of citations of the paper that reports this interaction (PMID 17955473)
10

Data Source:
BioGRID (pull down)

		CDKN2A	ACLY
Gene Name		cyclin-dependent kinase inhibitor 2A	ATP citrate lyase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Nuclear Body Senescence-associated Heterochromatin Focus Protein Complex	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Citrate Lyase Complex Membrane Extracellular Vesicular Exosome
	Molecular Function	P53 Binding DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Poly(A) RNA Binding NF-kappaB Binding Ubiquitin-protein Transferase Inhibitor Activity MDM2/MDM4 Family Protein Binding	ATP Citrate Synthase Activity Succinate-CoA Ligase (ADP-forming) Activity Protein Binding ATP Binding Metal Ion Binding Cofactor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Negative Regulation Of Cell-matrix Adhesion Transcription, DNA-templated RRNA Processing Negative Regulation Of Protein Kinase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Arrest Ras Protein Signal Transduction Negative Regulation Of Cell Proliferation Apoptotic Mitochondrial Changes Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Growth Negative Regulation Of B Cell Proliferation Regulation Of Protein Stability Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Protein Sumoylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Export From Nucleus Somatic Stem Cell Division Protein Stabilization Negative Regulation Of Ubiquitin-protein Transferase Activity Protein K63-linked Ubiquitination Positive Regulation Of Cell Cycle Arrest Cellular Senescence Replicative Senescence Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cellular Senescence	Citrate Metabolic Process Energy Reserve Metabolic Process Lipid Biosynthetic Process Coenzyme A Metabolic Process Triglyceride Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Lipid Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process
Pathways		Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic Oxidative Stress Induced Senescence Cellular Senescence Oncogene Induced Senescence	Fatty Acyl-CoA Biosynthesis Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Integration of energy metabolism ChREBP activates metabolic gene expression Triglyceride Biosynthesis
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 20622881) Breast cancer ( 23535729 20453838) Coronary artery calcification ( 23561647) Coronary heart disease ( 21626137 21971053 17554300 21378990) Endometriosis ( 23104006) Glioma ( 21531791 19578367) Intracranial aneurysm ( 18997786 20364137) Melanoma ( 21983787 19578364) Myocardial infarction ( 17478679) Myocardial infarction (early onset) ( 19198609) Platelet counts ( 22139419) Type 2 diabetes ( 21573907 18372903 20581827 19401414 17463246 17463248 17463249 23209189)
Protein-Protein Interactions		94 interactors: ACLY ACTB ACTG1 ACTN4 AHNAK ANKRD12 ARFIP2 BCL2L1 BECN1 CARF CCDC183 CCND1 CCND2 CCNG1 CDC45 CDC5L CDC6 CDC7 CDK4 CDK6 CDKN2AIP CDKN2C CRELD2 CTBP2 DEAF1 E2F1 E4F1 EEF2 EGR1 EPHA3 FN1 GAPDH GGA1 GGA3 GMNN GSPT1 HIF1A HIST3H2BB HNRNPA2B1 HNRNPC HNRNPU HSP90AA1 HSP90AB1 HSPA4 HSPA8 HUWE1 KAT5 MAPK10 MAPK8 MCM10 MCM2 MCM5 MCM6 MDM2 MMRN1 MTR MYC MYL12A NCL NMI ORC4 PCNA PDCD6 PEX19 PLEKHA8 PPP1R9B PRKCA PSMC3 RIN2 RPS7 RUVBL2 SERTAD1 SIVA1 SLC4A1 SMARCA4 SNRPA SNRPB TBRG1 TDRD7 TP63 TPI1 TRIP12 TUBA1A TUBA1C TUBB TUBB4B UBE2A UBE4B USP26 WRN YY1 ZFP91 ZNF227 ZNF410	5 interactors: APP CDKN2A GSK3B HGS PRKACA
Entrez ID		1029	47
HPRD ID		02542	00155
Ensembl ID		ENSG00000147889	ENSG00000131473
Uniprot IDs		G3XAG3 K7PML8 P42771 Q8N726	B4E3P0 P53396
PDB IDs		1A5E 1BI7 1DC2 2A5E	3MWD 3MWE 3PFF
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle G1/S Transition Of Mitotic Cell Cycle Response To Stress Cellular Response To Stress Regulation Of Metabolic Process Regulation Of Cell Cycle Response To Abiotic Stimulus Cellular Response To DNA Damage Stimulus Response To Radiation Negative Regulation Of Cell Cycle Response To Light Stimulus Regulation Of Mitotic Cell Cycle Cell Division Cellular Nitrogen Compound Metabolic Process Response To UV Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Replication DNA Replication Initiation Nitrogen Compound Metabolic Process Chromosome Organization Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process DNA Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Cellular Response To Radiation Regulation Of Protein Metabolic Process DNA-dependent DNA Replication Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Proliferation Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Stimulus DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation	Regulation Of Protein Export From Nucleus Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Protein Binding Positive Regulation Of Protein Export From Nucleus Regulation Of Proteolysis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Metabolic Process Negative Regulation Of Protein Kinase Activity Positive Regulation Of Cell Cycle Process Negative Regulation Of Kinase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Binding Regulation Of Intracellular Protein Transport Apoptotic Process Regulation Of Cardiac Muscle Hypertrophy Programmed Cell Death Positive Regulation Of Cell Cycle Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Positive Regulation Of Proteolysis Cell Death Death Negative Regulation Of Transferase Activity Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Signaling Regulation Of Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Phosphorylation Regulation Of Phosphorylation Regulation Of Mitotic Cell Cycle Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Regulation Of Cellular Ketone Metabolic Process
Tagcloud ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	anabolism bioenergetic bioenergetics chemoresistance clarified clearer complexified concepts dialog dysfunctional facets flexibility glutamine hk2 ldha likewise microenvironmental modulators mycn oncometabolites owing pgam1 progressed proof remodel stroma symbiosis translated warburg
Tagcloud (Difference) ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	anabolism bioenergetic bioenergetics chemoresistance clarified clearer complexified concepts dialog dysfunctional facets flexibility glutamine hk2 ldha likewise microenvironmental modulators mycn oncometabolites owing pgam1 progressed proof remodel stroma symbiosis translated warburg
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