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CDKN2A and YY1
Number of citations of the paper that reports this interaction (PubMedID
15210108
)
0
Data Source:
BioGRID
(pull down)
CDKN2A
YY1
Description
cyclin dependent kinase inhibitor 2A
YY1 transcription factor
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Nuclear Body
Protein-containing Complex
Senescence-associated Heterochromatin Focus
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromatin Silencing Complex
Nuclear Matrix
Ino80 Complex
PcG Protein Complex
Molecular Function
P53 Binding
DNA Binding
RNA Binding
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
SUMO Transferase Activity
Protein Kinase Binding
NF-kappaB Binding
Ligase Inhibitor Activity
Ubiquitin-protein Transferase Inhibitor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
MDM2/MDM4 Family Protein Binding
Disordered Domain Specific Binding
Ubiquitin Ligase Inhibitor Activity
Four-way Junction DNA Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
RNA Binding
Protein Binding
Zinc Ion Binding
Sequence-specific DNA Binding
SMAD Binding
Metal Ion Binding
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Autophagy Of Mitochondrion
Negative Regulation Of Cell-matrix Adhesion
RRNA Processing
Apoptotic Process
Ras Protein Signal Transduction
Negative Regulation Of Cell Population Proliferation
Epidermis Development
RRNA Transcription
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Protein Sumoylation
Keratinocyte Differentiation
Negative Regulation Of Cell Growth
Nuclear Body Organization
Negative Regulation Of B Cell Proliferation
Regulation Of Protein Stability
Protein Destabilization
Negative Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Protein Sumoylation
Mammary Gland Epithelial Cell Proliferation
Negative Regulation Of Mammary Gland Epithelial Cell Proliferation
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Protein Localization To Nucleus
Somatic Stem Cell Population Maintenance
Glucose Homeostasis
Positive Regulation Of Apoptotic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Keratinocyte Proliferation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleocytoplasmic Transport
Regulation Of Protein Export From Nucleus
Somatic Stem Cell Division
Protein Stabilization
Regulation Of Cell Cycle
Mitochondrial Depolarization
Apoptotic Process Involved In Mammary Gland Involution
Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
Cellular Response To Hydrogen Peroxide
Protein K63-linked Ubiquitination
Cellular Senescence
Replicative Senescence
Oncogene-induced Cell Senescence
Apoptotic Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Signal Transduction By P53 Class Mediator
Protein Localization To Nucleolus
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Ubiquitin Protein Ligase Activity
Amyloid Fibril Formation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Macrophage Apoptotic Process
Negative Regulation Of Protein Neddylation
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Regulation Of DNA Replication
DNA Repair
Regulation Of DNA Repair
DNA Recombination
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
RNA Localization
DNA Damage Response
Spermatogenesis
Anterior/posterior Pattern Specification
Response To UV-C
Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Hemopoiesis
Cell Differentiation
B Cell Differentiation
Negative Regulation Of Interferon-beta Production
Regulation Of Chromosome Organization
Cellular Response To UV
Response To Prostaglandin F
Positive Regulation Of DNA Repair
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Camera-type Eye Morphogenesis
Chromosome Organization
Regulation Of Cell Cycle
Regulation Of DNA Strand Elongation
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Interleukin-1
Immunoglobulin Heavy Chain V-D-J Recombination
Negative Regulation Of MiRNA Transcription
Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Cyclin D associated events in G1
Transcriptional Regulation by VENTX
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4
Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Apoptotic factor-mediated response
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
Regulation of TP53 Degradation
Stabilization of p53
Regulation of RUNX3 expression and activity
Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
Evasion of Oncogene Induced Senescence Due to p14ARF Defects
Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects
Nuclear events mediated by NFE2L2
Activation of anterior HOX genes in hindbrain development during early embryogenesis
UCH proteinases
DNA Damage Recognition in GG-NER
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Estrogen-dependent gene expression
Drugs
Diseases
Chronic myeloid leukemia (CML)
Non-small cell lung cancer
Malignant islet cell carcinoma
Adult T-cell leukemia
Esophageal cancer
Glioma
Pancreatic cancer
Nasopharyngeal cancer
Hepatocellular carcinoma
Squamous cell carcinoma
Penile cancer
Oral cancer
Malignant melanoma
Burkitt lymphoma
Gallbladder cancer
Bladder cancer
Laryngeal cancer
Cholangiocarcinoma
Malignant pleural mesothelioma
Osteosarcoma
Type II diabetes mellitus
GWAS
Abdominal aortic aneurysm (
20622881
)
Acute lymphoblastic leukemia (childhood) (
29348612
)
Acute lymphoblastic leukemia in childhood (B cell precursor) (
29632299
)
B-cell acute lymphoblastic leukaemia (
31767839
)
Basal cell carcinoma (
25855136
24403052
)
Basophil count (
32888494
)
Breast cancer (
23535729
29059683
20453838
)
Coronary artery calcification (
23561647
)
Coronary artery disease (
29263402
26708285
21239051
)
Coronary heart disease (
21971053
21378990
17554300
)
Coronary heart disease (SNP X SNP interaction) (
21626137
)
Coronary heart disease x type 2 diabetes interaction (
32541925
)
Endometrial cancer (
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Endometriosis (
23104006
)
Eosinophil count (
32888494
)
Esophageal squamous cell carcinoma (
25129146
)
Fasting plasma glucose (
25187374
)
Glioblastoma (
28346443
)
Glioma (
21531791
28346443
19578367
)
Inflammatory bowel disease (
27569725
)
Intracranial aneurysm (
18997786
20364137
)
Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) (
27418160
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Melanoma (
28212542
19578364
21983787
)
Monocyte count (
27863252
32888494
)
Multiple myeloma (
27363682
)
Myocardial infarction (
17478679
26708285
)
Myocardial infarction (early onset) (
19198609
)
Nasopharyngeal carcinoma (
26545403
)
Neutrophil percentage of white cells (
32888494
)
Non-glioblastoma glioma (
28346443
)
Non-small cell lung cancer (
31326317
)
Parental longevity (both parents in top 10%) (
29227965
)
Parental longevity (father's age at death) (
29227965
)
Platelet count (
27863252
22139419
32888494
)
Plateletcrit (
27863252
32888494
)
Red cell distribution width (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Spleen volume (
34128465
)
Type 2 diabetes (
23209189
17463246
17463248
17463249
18372903
19401414
20581827
21573907
30718926
23945395
24509480
26818947
26961502
27189021
32499647
29358691
30297969
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
White blood cell count (
27863252
32888494
)
Estimated glomerular filtration rate (
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Pulse pressure (
30224653
)
Interacting Genes
168 interacting genes:
-
ACLY
ACTB
ACTG1
ACTN4
AHNAK
AKT1
ALDOB
ANAPC15
ANGPTL4
ANKRA2
ANKRD12
AOPEP
ARFIP2
ARNT
ASPRV1
AZIN1
BAAT
BCL2L1
BECN1
CARF
CASC3
CCDC180
CCDC183
CCND2
CCNDBP1
CCNE1
CCNG1
CD44
CDC14B
CDC42
CDC45
CDC5L
CDC6
CDC7
CDK4
CDK6
CDKN2AIP
CDKN2C
CENPA
CRELD2
CTBP2
CTSV
CYLC2
DEAF1
E2F1
E4F1
EEF2
EFHC2
EGR1
EPHA2
EPHA3
EXOC2
FGFR4
FN1
FRAT2
GALNT12
GAPDH
GGA1
GGA3
GLIS1
GLIS2
GMNN
GSPT1
H2BC26
HGF
HIF1A
HLA-DOB
HNRNPA2B1
HNRNPC
HNRNPU
HRAS
HSP90AA1
HSP90AB1
HSPA4
HSPA8
HUWE1
ISOC2
KAT5
LATS2
MAF1
MAP2K1
MAP2K5
MAP3K5
MAPK10
MAPK14
MAPK3
MAPK8
MCM10
MCM2
MCM5
MCM6
MDM2
MDM4
MKRN1
MMRN1
MTR
MYC
MYL12A
NAT2
NCL
NMI
NOP53
NPM1
NSD3
ORC4
PCNA
PDCD6
PDGFRA
PEX19
PPP1R9B
PRKCA
PSMC3
PTP4A3
RAF1
RASA1
RASSF1
RBM26
RIN2
RPL11
RPS7
RUVBL2
SEC61B
SERTAD1
SFRP4
SGK1
SIVA1
SIX2
SLC4A1
SMARCA4
SNRPA
SNRPB
SOX3
SOX4
STK11
TBRG1
TDRD7
TEAD2
TERT
TFDP1
TGFB1
TMEFF1
TMOD1
TP63
TPI1
TRIM28
TRIP12
TSC1
TUBA1A
TUBA1C
TUBB
TUBB4B
UBC
UBE2A
UBE4B
UBL7
USP26
VAMP1
VHL
WRN
YY1
ZFP91
ZGRF1
ZNF227
ZNF410
ZNF420
ZNF687
ZUP1
98 interacting genes:
ALOXE3
APP
ATF2
ATF6
ATF7
AURKA
BAP1
BRCA1
CDKN2A
CEBPA
CEP76
CREB1
CREBBP
CRKL
CYSRT1
DNMT3L
E2F2
E2F3
EED
EP300
ESM1
FHL2
FKBP1A
FKBP3
FOXP1
FOXP2
FOXP4
GFER
GMCL1
GRN
GTF2I
HDAC2
HDAC3
HMGB1
HNF1B
HOXA11
IL10
ITCH
KAT2B
KRTAP1-3
KRTAP1-5
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP12-3
KRTAP17-1
KRTAP2-3
KRTAP2-4
KRTAP4-2
KRTAP4-5
KRTAP5-6
KRTAP9-3
KRTAP9-8
MDFI
MED20
MTA2
MYC
NEDD4L
NFIC
NFIX
NFKB1
NOTCH1
NPM1
NR1H2
PIAS4
PLEKHF2
PPIA
PSMD9
RAF1
RYBP
SAP30
SF3A2
SKP2
SLC39A7
SMAD1
SMAD2
SMAD3
SMURF2
SP1
SPRY1
SREBF1
TESK1
TFCP2
TP53
TRIM42
TWIST1
UBE2I
UHRF2
USP21
USP7
VWC2
XAGE1A
XAGE1B
YAF2
ZNF232
ZNF85
ZRANB2
Entrez ID
1029
7528
HPRD ID
02542
02482
Ensembl ID
ENSG00000147889
ENSG00000100811
Uniprot IDs
K7PML8
P42771
Q8N726
P25490
PDB IDs
1A5E
1BI7
1DC2
2A5E
7OZT
1UBD
1ZNM
4C5I
Enriched GO Terms of Interacting Partners
?
Nucleus
Nucleoplasm
Cellular Response To Stress
Regulation Of Cell Cycle
Regulation Of Primary Metabolic Process
DNA Damage Response
Regulation Of Cell Population Proliferation
Response To Stress
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Protein Stability
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Metabolic Process
Cytosol
Regulation Of DNA Metabolic Process
Regulation Of Protein Metabolic Process
Response To Radiation
Cytoplasm
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Replication Initiation
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Mitotic Cell Cycle
DNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Nucleotide Binding
Regulation Of Cellular Component Organization
Macromolecule Metabolic Process
Protein-containing Complex
Negative Regulation Of Macromolecule Metabolic Process
Cellular Senescence
ATP Binding
Positive Regulation Of Cell Cycle Process
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Catalytic Activity
Cellular Response To Radiation
Positive Regulation Of Transcription By RNA Polymerase II
Nucleic Acid Metabolic Process
Positive Regulation Of Cell Cycle Phase Transition
Protein Stabilization
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of Fibroblast Proliferation
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Nucleoplasm
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Intermediate Filament
Chromatin
Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Activity
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Keratin Filament
Epigenetic Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
DNA-templated Transcription
DNA Binding
Cis-regulatory Region Sequence-specific DNA Binding
Positive Regulation Of Biosynthetic Process
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Metabolic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription By RNA Polymerase II
Negative Regulation Of Gene Expression
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Binding
Identical Protein Binding
Regulation Of MiRNA Metabolic Process
Regulation Of Programmed Cell Death
Transcription Regulator Complex
Chromatin Remodeling
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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