SYT11 and SGTA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		SYT11	SGTA
Description		synaptotagmin 11	small glutamine rich tetratricopeptide repeat co-chaperone alpha
Image		No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Cytoplasm Lysosome Lysosomal Membrane Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Synaptic Vesicle Postsynaptic Density Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Vesicle Early Phagosome Cell Projection Neuron Projection Dendritic Spine Perikaryon Synapse Phagocytic Vesicle Presynaptic Active Zone Membrane Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Inhibitory Synapse Exocytic Vesicle Dopaminergic Synapse Presynapse	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane TRC Complex
	Molecular Function	SNARE Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Translation Initiation Factor Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding Beta-tubulin Binding Calcium Ion Sensor Activity	Protein Binding Identical Protein Binding Molecular Adaptor Activity BAT3 Complex Binding
	Biological Process	Plasma Membrane Repair Negative Regulation Of Cytokine Production Vesicle Fusion Autophagy Learning Memory Response To Wounding Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Dopamine Secretion Negative Regulation Of Endocytosis Negative Regulation Of Neurotransmitter Secretion Negative Regulation Of Phagocytosis Establishment Of Vesicle Localization Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Defense Response To Bacterium Negative Regulation Of Secretion By Cell Negative Regulation Of Microglial Cell Activation Regulation Of Phagosome Maturation Positive Regulation Of Protein Localization To Phagocytic Vesicle Calcium Ion Regulated Lysosome Exocytosis	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of ERAD Pathway Positive Regulation Of ERAD Pathway Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Parkinson's disease ( 25064009 21292315) Serum cancer antigen 15.3 levels ( 31666285) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		6 interacting genes: APPBP2 GPR35 PRKN SGTA SGTB SYNCRIP	182 interacting genes: ADAM21 ADIPOQ ADRM1 AGR2 AGR3 AOC3 BAG6 BCL2L12 BTC C1QA C1QL4 C1QTNF1 C1QTNF5 C1QTNF6 C3orf52 C5orf46 CD79B CD99 CD99L2 CDH15 CDSN CHRNG COL1A2 COL8A2 CREB3L3 CSF1 CST1 CTAG1A CTAG1B CTSL CXCL8 CYB5R1 DEFA6 DEFB131A DKK3 DMKN EDA2R EDAR EFEMP1 EFEMP2 ERP27 ERP29 ETNK1 EVA1B F11R FERD3L FGF21 FIP1L1 FKBP7 FSTL1 FXYD2 FXYD7 FZD7 GABARAPL2 GAL GALP GHR GIP GPX7 GRN GUCA2A GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA4 IER3 IGFBP6 IGL IGLC1 IL6ST IRF3 IRF5 ITPRIPL1 KASH5 KCNA1 KCNA10 KCNE5 KLHL20 KRT6A KTN1 LAIR2 LAT LCN2 LDLRAD4 LSMEM2 MRAP2 MS4A3 MSMB MSTN MYDGF MYOC NAXD NME3 NPVF NR3C1 NRSN2 NXF1 PAGE3 PBXIP1 PCDHA4 PCDHGA4 PFN2 PGLYRP2 PGR PIAS1 PLAAT4 PMEPA1 PODXL PPIB PPIC PPP1R3C PRAP1 PRB4 PRRG2 PSORS1C2 PTN PYY RCN1 RNASE10 RNF144A RNF144B RNF170 RPN1 SDC4 SDF2L1 SERPINE1 SERPINI2 SGCA SGTB SHISA4 SHISA5 SLPI SMAGP SMIM14 SMIM5 SOD3 SPINK9 SPN SPP1 SPPL2A SRGN SRL STMP1 SUOX SYT11 SYT4 TFF3 TFRC TGFA TIAM1 TMEM154 TMEM174 TMEM230 TMEM31 TMEM98 TMPO TMPRSS11D TMUB2 TNFRSF10C TNFRSF13B TNFRSF19 TNFRSF1A TNFRSF21 TNFSF12 TRIM5 TWSG1 TXNDC12 UBL4A UBQLN2 UPK3A USP14 USP5 USP9X VIP WBP1L WFDC12 WFDC13 WFDC5 ZBTB8B ZG16 ZG16B
Entrez ID		23208	6449
HPRD ID		12289	04568
Ensembl ID		ENSG00000132718	ENSG00000104969
Uniprot IDs		Q9BT88	O43765
PDB IDs			2VYI 4CPG 4GOD 4GOE 4GOF
Enriched GO Terms of Interacting Partners?		TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Hsp70 Protein Binding Negative Regulation Of Response To Endoplasmic Reticulum Stress Membrane Protein-folding Chaperone Binding Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Mitochondrial Fusion Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Cellular Response To L-glutamine Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Protein Targeting To Membrane BAT3 Complex Binding MRNA Editing Complex GAIT Complex Muscle Cell Projection Membrane Cellular Localization Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Endosome Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Neurotransmitter Uptake	Extracellular Region Extracellular Space Protein Binding Endoplasmic Reticulum Lumen Response To Bacterium Defense Response To Bacterium Collagen Trimer Response To Stress Membrane Response To Other Organism Antimicrobial Humoral Response Endoplasmic Reticulum Immune System Process Regulation Of Immune System Process Humoral Immune Response Peptidase Inhibitor Activity Negative Regulation Of Cell Activation Positive Regulation Of Leukocyte Migration Serine-type Endopeptidase Inhibitor Activity Defense Response Extracellular Exosome Defense Response To Symbiont Negative Regulation Of Proteasomal Protein Catabolic Process Antibacterial Humoral Response Plasma Membrane Immune Response Defense Response To Other Organism Negative Regulation Of Leukocyte Activation Identical Protein Binding Negative Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Response To External Biotic Stimulus Tumor Necrosis Factor Receptor Activity Negative Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Immune System Process Hormone Activity Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Glucocorticoid Metabolic Process Growth Factor Activity Fibronectin Binding Macrophage Apoptotic Process BAT3 Complex Regulation Of Cell Adhesion Protein Folding Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Lymphocyte Proliferation Epidermal Growth Factor Receptor Binding Negative Regulation Of Mononuclear Cell Proliferation
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