SYT11 and APPBP2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SYT11	APPBP2
Gene Name		synaptotagmin XI	amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Synaptic Vesicle Cell Junction Synaptic Vesicle Membrane	Nucleus Cytoplasm Microtubule Microtubule Associated Complex Cytoplasmic Vesicle Membrane
	Molecular Function	Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding	Microtubule Motor Activity Protein Binding
	Biological Process	Transport Negative Regulation Of Neurotransmitter Secretion	Intracellular Protein Transport Metabolic Process Intracellular Transport
Pathways
Drugs
Diseases
GWAS		Parkinson's disease ( 21292315)
Protein-Protein Interactions		4 interactors: APPBP2 PARK2 SGTA SYNCRIP	79 interactors: AHCY AIM2 AK3 ANKRD10 APP AR ARMCX5 C1orf50 C6orf226 CALM3 CCDC85C CCNL1 CDK16 CHMP5 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CTC1 DCD DHRS2 DPEP1 EID3 EPT1 ERO1L FAM19A4 FAM92A1 FSTL1 FXYD7 GALNT3 GCSAM GP9 GSTP1 HIPK4 HIST1H2AK HSPA4 KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MFSD3 MGC34796 MLLT3 MUL1 NFYA NPRL3 PCSK5 PI4KAP2 PPP1R8 PRKAA2 PRKACB PYROXD2 RASSF5 RNF128 RNF34 RRS1 SELV SLC22A6 SLC25A23 SNX5 ST8SIA5 SYNRG SYT11 TAF11 TBL3 TCF25 UBE2R2 UGGT2 WAS WDR24 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		23208	10513
HPRD ID		12289	05616
Ensembl ID		ENSG00000132718	ENSG00000062725
Uniprot IDs		Q9BT88	Q92624
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Protein Linear Polyubiquitination Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Manganese Ion CRD-mediated MRNA Stabilization Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrion Degradation Dopamine Transport Aggresome Assembly Regulation Of Mitochondrial Fission Neurotransmitter Uptake Norepinephrine Metabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Actin Filament Bundle Assembly Synaptic Transmission, Dopaminergic Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Zinc Ion Homeostasis Negative Regulation Of Release Of Cytochrome C From Mitochondria Response To Manganese Ion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Viral Process Cellular Response To Ammonium Ion Regulation Of Dopamine Secretion Cellular Response To Toxic Substance Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Monoamine Transport Mitochondrial Fission MRNA Stabilization Cellular Response To Catecholamine Stimulus Negative Regulation Of Oxidative Stress-induced Cell Death Startle Response Mitochondrion Degradation Dopamine Metabolic Process Positive Regulation Of Cytokine-mediated Signaling Pathway	Regulation Of Defense Response To Virus By Host Response To Stress Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Homocysteine Metabolic Process Cellular Response To Organic Substance
Tagcloud ?		ago2 assigned c2 c2a c2b calcium constituting fmrp golgi insensitive interacted isoforms link micrornas partners q repeats risc silencing snare snd snd1 synaptotagmin synaptotagmins tandem traffic transmembrane vesicles vti1a	10kb arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Difference) ?		ago2 assigned c2 c2a c2b calcium constituting fmrp golgi insensitive interacted isoforms link micrornas partners q repeats risc silencing snare snd snd1 synaptotagmin synaptotagmins tandem traffic transmembrane vesicles vti1a	10kb arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Intersection) ?