SYT11

Description		synaptotagmin 11
Image		No pdb structure
GO Annotations	Cellular Component	Phagocytic Cup Cytoplasm Lysosome Lysosomal Membrane Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Synaptic Vesicle Postsynaptic Density Membrane Axon Dendrite Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Vesicle Early Phagosome Cell Projection Neuron Projection Dendritic Spine Perikaryon Synapse Phagocytic Vesicle Presynaptic Active Zone Membrane Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Inhibitory Synapse Exocytic Vesicle Dopaminergic Synapse Presynapse
	Molecular Function	SNARE Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Translation Initiation Factor Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding Beta-tubulin Binding Calcium Ion Sensor Activity
	Biological Process	Plasma Membrane Repair Negative Regulation Of Cytokine Production Vesicle Fusion Autophagy Learning Memory Response To Wounding Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Dopamine Secretion Negative Regulation Of Endocytosis Negative Regulation Of Neurotransmitter Secretion Negative Regulation Of Phagocytosis Establishment Of Vesicle Localization Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Synaptic Vesicle Endocytosis Regulation Of Defense Response To Bacterium Negative Regulation Of Secretion By Cell Negative Regulation Of Microglial Cell Activation Regulation Of Phagosome Maturation Positive Regulation Of Protein Localization To Phagocytic Vesicle Calcium Ion Regulated Lysosome Exocytosis
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Parkinson's disease ( 25064009 21292315) Serum cancer antigen 15.3 levels ( 31666285) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Novel Interacting Genes		1 novel interacting genes: PLEKHO1
Interacting Genes		6 interacting genes: APPBP2 GPR35 PRKN SGTA SGTB SYNCRIP
Entrez ID		23208
HPRD ID		12289
Ensembl ID		ENSG00000132718
Uniprot IDs		Q9BT88
PDB IDs
Enriched GO Terms of Interacting Partners?		TRC Complex Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Protein Targeting To ER Hsp70 Protein Binding Negative Regulation Of Response To Endoplasmic Reticulum Stress Membrane Protein-folding Chaperone Binding Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Mitochondrial Fusion Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Response To Curcumin Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Cellular Response To L-glutamine Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Hydrogen Sulfide Negative Regulation Of Exosomal Secretion Protein Targeting To Membrane BAT3 Complex Binding MRNA Editing Complex GAIT Complex Muscle Cell Projection Membrane Cellular Localization Lewy Body Regulation Of Spontaneous Synaptic Transmission Type 2 Mitophagy Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mitochondrial Fission Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Endosome Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Neurotransmitter Uptake
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