MYCBP2 and HUNK

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		MYCBP2	HUNK
Description		MYC binding protein 2	hormonally up-regulated Neu-associated kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Cell Projection	Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Axon Guidance Motor Neuron Axon Guidance Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Ubiquitination Branchiomotor Neuron Axon Guidance Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Circadian Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Rhythmic Process Cell Morphogenesis Involved In Neuron Differentiation Neuromuscular Process Regulation Of Cytoskeleton Organization Axon Development Protein K48-linked Ubiquitination Regulation Of Axon Guidance	Signal Transduction Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS		Chronotype ( 30696823) Iris heterochromicity ( 30895295) Morning person ( 30696823) Preeclampsia ( 23551011) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Crohn's disease ( 32581322) Joint damage progression in ACPA-negative rheumatoid arthritis ( 26077402) LDL cholesterol levels in HIV infection ( 33109212) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Type 2 diabetes ( 21490949) Vitiligo ( 19890347)
Interacting Genes		50 interacting genes: AATF APPL1 ARL6IP5 ASB8 ATP13A2 BTG3 CALM1 CD81 CEBPA CFL1 CUEDC2 DHRS4L2 DSCR9 DYRK1A ERBB3 FHL3 FSCN1 HSP90AB1 HUNK IGFBP6 LCOR LDHB LSM14A MYC NDUFB9 NMNAT2 OAZ1 PABPN1 PI4KB PRXL2A PTPN12 PUF60 RGPD8 RPS5 RSPH1 SERPINB6 SOD1 SPARCL1 SPRYD3 SRPK2 TBC1D9 TBC1D9B TBR1 TTN UBE2D2 UBE2D3 UBE2L3 UCHL1 YWHAG YWHAQ	92 interacting genes: AARS1 ABLIM1 ACTR8 AGAP3 AIP AKAP8L AKR1C3 ALAD ANXA7 APBA2 APPL2 ARMCX4 ASCL1 ASPA ATP5F1B BIN1 CAMK1 CCAR1 CLU COG2 COPA COPS4 COPS5 CTDSP1 CTR9 CXXC5 DIS3L DLAT DLST DNAJA1 DST EEF1A2 EFNA1 EIF4G1 EPRS1 GEN1 HEATR6 HEY1 IFT81 IFT88 KDM6A KIF3A LIMK1 LNX1 LRSAM1 LURAP1 MAGED1 MBD1 MCHR1 MGAT5B MOAP1 MORF4L2 MTMR10 MYCBP2 N4BP2L2 NAPA NEUROD2 OLR1 PICK1 PITHD1 PPP1R16B PTPRA PTPRD RAB5B RABEP1 SH2B1 SLC6A1 SMARCE1 SMYD2 SNRNP48 SNRNP70 SORBS1 SPARCL1 STMN1 STUB1 TAF1 TOMM6 TRIM68 TTC28 UBE2O USP8 VCPIP1 VPS35L VSNL1 ZBTB44 ZNF197 ZNF292 ZNF343 ZNF655 ZNF662 ZNF76 ZNF793
Entrez ID		23077	30811
HPRD ID		10104	09410
Ensembl ID		ENSG00000005810	ENSG00000142149
Uniprot IDs		O75592	P57058
PDB IDs		5O6C 6T7F
Enriched GO Terms of Interacting Partners?		Cytoplasm Intracellular Signal Transduction	Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of RNA Biosynthetic Process DeNEDDylase Activity
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