MYCBP2 and FSCN1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		MYCBP2	FSCN1
Description		MYC binding protein 2	fascin actin-bundling protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Cell Projection	Stress Fiber Ruffle Podosome Cytoplasm Cytosol Cytoskeleton Microvillus Cell-cell Junction Cell Cortex Actin Cytoskeleton Lamellipodium Filopodium Growth Cone Cell Leading Edge Cell Projection Membrane Cell Projection Microspike Extracellular Exosome Anchoring Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Actin Binding Protein Binding Protein-macromolecule Adaptor Activity Cadherin Binding Actin Filament Binding
	Biological Process	Axon Guidance Motor Neuron Axon Guidance Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Ubiquitination Branchiomotor Neuron Axon Guidance Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Circadian Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Rhythmic Process Cell Morphogenesis Involved In Neuron Differentiation Neuromuscular Process Regulation Of Cytoskeleton Organization Axon Development Protein K48-linked Ubiquitination Regulation Of Axon Guidance	Actin Filament Organization Cell-cell Junction Assembly Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Lamellipodium Assembly Cell Migration Microspike Assembly Actin Cytoskeleton Organization Parallel Actin Filament Bundle Assembly Regulation Of Microvillus Assembly Regulation Of Actin Cytoskeleton Organization Establishment Of Apical/basal Cell Polarity Cell Motility Actin Filament Bundle Assembly Positive Regulation Of Filopodium Assembly Positive Regulation Of Podosome Assembly Positive Regulation Of Extracellular Matrix Disassembly
Pathways			Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS		Chronotype ( 30696823) Iris heterochromicity ( 30895295) Morning person ( 30696823) Preeclampsia ( 23551011) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		50 interacting genes: AATF APPL1 ARL6IP5 ASB8 ATP13A2 BTG3 CALM1 CD81 CEBPA CFL1 CUEDC2 DHRS4L2 DSCR9 DYRK1A ERBB3 FHL3 FSCN1 HSP90AB1 HUNK IGFBP6 LCOR LDHB LSM14A MYC NDUFB9 NMNAT2 OAZ1 PABPN1 PI4KB PRXL2A PTPN12 PUF60 RGPD8 RPS5 RSPH1 SERPINB6 SOD1 SPARCL1 SPRYD3 SRPK2 TBC1D9 TBC1D9B TBR1 TTN UBE2D2 UBE2D3 UBE2L3 UCHL1 YWHAG YWHAQ	14 interacting genes: ACTA1 ACTC1 CTNNB1 DNAJB9 MAPK8IP2 MYCBP2 NGFR OXTR PRKCA PRKCD RAB1A SMURF1 USP10 YWHAQ
Entrez ID		23077	6624
HPRD ID		10104	04068
Ensembl ID		ENSG00000005810	ENSG00000075618
Uniprot IDs		O75592	A0A384MEG1 B3KTA3 Q16658
PDB IDs		5O6C 6T7F	1DFC 3LLP 3P53 4GOV 4GOY 4GP0 4GP3 6B0T 6I0Z 6I10 6I11 6I12 6I13 6I14 6I15 6I16 6I17 6I18 7ZAU 8VO5 8VO6 8VO7 8VO8 8VO9 8VOA
Enriched GO Terms of Interacting Partners?		Cytoplasm Intracellular Signal Transduction	Extracellular Exosome Positive Regulation Of Metabolic Process Skeletal Muscle Thin Filament Assembly Mesenchyme Migration Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Protein Kinase C Signaling Cytoplasm Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Intracellular Signaling Cassette Proteasomal Protein Catabolic Process Negative Regulation Of Glial Cell Apoptotic Process Ectoderm Development Developmental Process I-SMAD Binding Diacylglycerol-dependent Serine/threonine Kinase Activity Cytosol Positive Regulation Of Glycoprotein Metabolic Process Protein Catabolic Process Apoptotic Signaling Pathway Myosin Binding Transmembrane Transporter Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Multicellular Organismal Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Regulation Of Platelet Aggregation Positive Regulation Of Gene Expression Regulation Of Synapse Assembly Negative Regulation Of Intracellular Signal Transduction Hair Follicle Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Protein-containing Complex Central Nervous System Neuron Axonogenesis Lamellipodium Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Muscle Contraction Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Thymus Development Glial Cell Fate Determination SMAD Binding Cell-cell Junction Regulation Of Protein Localization
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