MYCBP2 and PI4KB

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		MYCBP2	PI4KB
Description		MYC binding protein 2	phosphatidylinositol 4-kinase beta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Cell Projection	Golgi Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Endomembrane System Membrane Rough Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding 1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity 14-3-3 Protein Binding
	Biological Process	Axon Guidance Motor Neuron Axon Guidance Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Ubiquitination Branchiomotor Neuron Axon Guidance Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Circadian Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Rhythmic Process Cell Morphogenesis Involved In Neuron Differentiation Neuromuscular Process Regulation Of Cytoskeleton Organization Axon Development Protein K48-linked Ubiquitination Regulation Of Axon Guidance	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Receptor-mediated Endocytosis Lysosome Organization Signal Transduction Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol-mediated Signaling Inner Ear Development
Pathways			Synthesis of PIPs at the Golgi membrane
Drugs			Fostamatinib
Diseases
GWAS		Chronotype ( 30696823) Iris heterochromicity ( 30895295) Morning person ( 30696823) Preeclampsia ( 23551011) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Body mass index ( 26426971) Gut microbiota (functional units) ( 27694959)
Interacting Genes		50 interacting genes: AATF APPL1 ARL6IP5 ASB8 ATP13A2 BTG3 CALM1 CD81 CEBPA CFL1 CUEDC2 DHRS4L2 DSCR9 DYRK1A ERBB3 FHL3 FSCN1 HSP90AB1 HUNK IGFBP6 LCOR LDHB LSM14A MYC NDUFB9 NMNAT2 OAZ1 PABPN1 PI4KB PRXL2A PTPN12 PUF60 RGPD8 RPS5 RSPH1 SERPINB6 SOD1 SPARCL1 SPRYD3 SRPK2 TBC1D9 TBC1D9B TBR1 TTN UBE2D2 UBE2D3 UBE2L3 UCHL1 YWHAG YWHAQ	5 interacting genes: MYCBP2 NCS1 YWHAB YWHAG YWHAQ
Entrez ID		23077	5298
HPRD ID		10104	11805
Ensembl ID		ENSG00000005810	ENSG00000143393
Uniprot IDs		O75592	A0A0B4J1S8 Q9UBF8
PDB IDs		5O6C 6T7F	2N73 4D0L 4D0M 4WAE 4WAG 5C46 5C4G 5EUQ 5FBL 5FBQ 5FBR 5FBV 5FBW 5LX2 5NAS 6GL3 8Q6F 8Q6G 8Q6H 8VOF
Enriched GO Terms of Interacting Partners?		Cytoplasm Intracellular Signal Transduction	Protein Domain Specific Binding Protein Targeting Protein Sequestering Activity Focal Adhesion Identical Protein Binding Protein Kinase C Inhibitor Activity
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