MYCBP2 and SERPINB6

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		MYCBP2	SERPINB6
Description		MYC binding protein 2	serpin family B member 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Cell Projection	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Secretory Granule Membrane Extracellular Matrix Extracellular Exosome Tertiary Granule Membrane Serine Protease Inhibitor Complex Ficolin-1-rich Granule Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protease Binding Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Axon Guidance Motor Neuron Axon Guidance Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Ubiquitination Branchiomotor Neuron Axon Guidance Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Circadian Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Rhythmic Process Cell Morphogenesis Involved In Neuron Differentiation Neuromuscular Process Regulation Of Cytoskeleton Organization Axon Development Protein K48-linked Ubiquitination Regulation Of Axon Guidance	Sensory Perception Of Sound Cellular Response To Osmotic Stress
Pathways			Neutrophil degranulation Dissolution of Fibrin Clot
Drugs			Drotrecogin alfa
Diseases
GWAS		Chronotype ( 30696823) Iris heterochromicity ( 30895295) Morning person ( 30696823) Preeclampsia ( 23551011) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Chronic lymphocytic leukemia ( 26956414) Crohn's disease ( 32581322)
Interacting Genes		50 interacting genes: AATF APPL1 ARL6IP5 ASB8 ATP13A2 BTG3 CALM1 CD81 CEBPA CFL1 CUEDC2 DHRS4L2 DSCR9 DYRK1A ERBB3 FHL3 FSCN1 HSP90AB1 HUNK IGFBP6 LCOR LDHB LSM14A MYC NDUFB9 NMNAT2 OAZ1 PABPN1 PI4KB PRXL2A PTPN12 PUF60 RGPD8 RPS5 RSPH1 SERPINB6 SOD1 SPARCL1 SPRYD3 SRPK2 TBC1D9 TBC1D9B TBR1 TTN UBE2D2 UBE2D3 UBE2L3 UCHL1 YWHAG YWHAQ	8 interacting genes: F10 F2 KLK2 MYCBP2 PLAU PLG PROC SUMO2
Entrez ID		23077	5269
HPRD ID		10104	01413
Ensembl ID		ENSG00000005810	ENSG00000124570
Uniprot IDs		O75592	A0A024QZX5 A0A087X1N8 A0A2R8YD12 P35237
PDB IDs		5O6C 6T7F
Enriched GO Terms of Interacting Partners?		Cytoplasm Intracellular Signal Transduction	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Coagulation Blood Coagulation Hemostasis Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Peptidase Activity Negative Regulation Of Fibrinolysis Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Regulation Of Fibrinolysis Regulation Of Body Fluid Levels Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Regulation Of Wound Healing Protein Metabolic Process Regulation Of Response To Wounding Proteolysis Positive Regulation Of Wound Healing Endopeptidase Activity Extracellular Space Golgi Lumen External Side Of Plasma Membrane Hydrolase Activity Macromolecule Metabolic Process Protein Processing Extracellular Region Biological Process Involved In Interaction With Symbiont Zymogen Activation Regulation Of Biological Quality Endoplasmic Reticulum Lumen Protein Maturation Regulation Of Proteolysis Regulation Of Locomotion Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Multicellular Organismal Process Blood Microparticle Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Receptor Ligand Activity Positive Regulation Of Cell Migration Negative Regulation Of Proteolysis Thrombospondin Receptor Activity Positive Regulation Of Cell Motility Regulation Of Smooth Muscle Cell-matrix Adhesion Trans-synaptic Signaling By BDNF Positive Regulation Of Fibrinolysis
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