HUNK and DLAT

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HUNK	DLAT
Description		hormonally up-regulated Neu-associated kinase	dihydrolipoamide S-acetyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Dihydrolipoyllysine-residue Acetyltransferase Activity Protein Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity Identical Protein Binding
	Biological Process	Signal Transduction Intracellular Signal Transduction	Glucose Metabolic Process Pyruvate Decarboxylation To Acetyl-CoA Tricarboxylic Acid Cycle Pyruvate Catabolic Process
Pathways			Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Protein lipoylation PDH complex synthesizes acetyl-CoA from PYR
Drugs			NADH Radicicol Dihydrolipoic Acid
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Crohn's disease ( 32581322) Joint damage progression in ACPA-negative rheumatoid arthritis ( 26077402) LDL cholesterol levels in HIV infection ( 33109212) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Type 2 diabetes ( 21490949) Vitiligo ( 19890347)	Brain morphology (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		92 interacting genes: AARS1 ABLIM1 ACTR8 AGAP3 AIP AKAP8L AKR1C3 ALAD ANXA7 APBA2 APPL2 ARMCX4 ASCL1 ASPA ATP5F1B BIN1 CAMK1 CCAR1 CLU COG2 COPA COPS4 COPS5 CTDSP1 CTR9 CXXC5 DIS3L DLAT DLST DNAJA1 DST EEF1A2 EFNA1 EIF4G1 EPRS1 GEN1 HEATR6 HEY1 IFT81 IFT88 KDM6A KIF3A LIMK1 LNX1 LRSAM1 LURAP1 MAGED1 MBD1 MCHR1 MGAT5B MOAP1 MORF4L2 MTMR10 MYCBP2 N4BP2L2 NAPA NEUROD2 OLR1 PICK1 PITHD1 PPP1R16B PTPRA PTPRD RAB5B RABEP1 SH2B1 SLC6A1 SMARCE1 SMYD2 SNRNP48 SNRNP70 SORBS1 SPARCL1 STMN1 STUB1 TAF1 TOMM6 TRIM68 TTC28 UBE2O USP8 VCPIP1 VPS35L VSNL1 ZBTB44 ZNF197 ZNF292 ZNF343 ZNF655 ZNF662 ZNF76 ZNF793	10 interacting genes: FOXP1 HMGB1 HUNK PDHA1 PDHX PDK1 PDK2 PDK3 PDK4 PRKD3
Entrez ID		30811	1737
HPRD ID		09410	10578
Ensembl ID		ENSG00000142149	ENSG00000150768
Uniprot IDs		P57058	A0A7P0T997 A0A7P0TAG1 A0A7P0TAX2 A0A7P0TBE2 A0A7P0TBK2 E9PEJ4 H0YDD4 P10515 Q86YI5
PDB IDs			1FYC 1Y8N 1Y8O 1Y8P 2DNE 2PNR 2Q8I 3B8K 3CRK 3CRL 6CT0 6H55 8PIU
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of RNA Biosynthetic Process DeNEDDylase Activity	Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Pyruvate Dehydrogenase Complex Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Glucose Metabolic Process Mitochondrial Matrix Regulation Of Amide Metabolic Process Protein Kinase Activity Regulation Of Fatty Acid Metabolic Process Kinase Activity Regulation Of Small Molecule Metabolic Process Regulation Of Ketone Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Lipid Metabolic Process Acetyl-CoA Biosynthetic Process Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Glucose Metabolic Process ATP Binding Carbohydrate Metabolic Process Cellular Response To Stress Mitochondrion Hexose Metabolic Process Acetyl-CoA Metabolic Process Monosaccharide Metabolic Process Nucleotide Binding Transferase Activity T-helper Cell Differentiation Regulation Of Phosphorus Metabolic Process Cellular Response To Fatty Acid T Cell Differentiation Involved In Immune Response CD4-positive, Alpha-beta T Cell Differentiation Response To Fatty Acid Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of Myeloid Progenitor Cell Differentiation Macrophage Activation Regulation Of Interleukin-12 Production Alpha-beta T Cell Differentiation Pyruvate Metabolic Process T Cell Activation Involved In Immune Response Response To Lipid Insulin Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Negative Regulation Of Apoptotic Cell Clearance Dihydrolipoyllysine-residue Acetyltransferase Activity Positive Regulation Of Interleukin-21 Production Acyl-CoA Metabolic Process
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