HUNK and PPP1R16B

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HUNK	PPP1R16B
Description		hormonally up-regulated Neu-associated kinase	protein phosphatase 1 regulatory subunit 16B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Plasma Membrane Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Enzyme Inhibitor Activity Protein Binding Myosin Phosphatase Regulator Activity Protein Phosphatase Regulator Activity
	Biological Process	Signal Transduction Intracellular Signal Transduction	Positive Regulation Of Endothelial Cell Proliferation Regulation Of Filopodium Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Establishment Of Endothelial Barrier Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 32581322) Joint damage progression in ACPA-negative rheumatoid arthritis ( 26077402) LDL cholesterol levels in HIV infection ( 33109212) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Type 2 diabetes ( 21490949) Vitiligo ( 19890347)	Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis ( 28714907) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847) Huntington's disease progression ( 28642124) Mean corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		92 interacting genes: AARS1 ABLIM1 ACTR8 AGAP3 AIP AKAP8L AKR1C3 ALAD ANXA7 APBA2 APPL2 ARMCX4 ASCL1 ASPA ATP5F1B BIN1 CAMK1 CCAR1 CLU COG2 COPA COPS4 COPS5 CTDSP1 CTR9 CXXC5 DIS3L DLAT DLST DNAJA1 DST EEF1A2 EFNA1 EIF4G1 EPRS1 GEN1 HEATR6 HEY1 IFT81 IFT88 KDM6A KIF3A LIMK1 LNX1 LRSAM1 LURAP1 MAGED1 MBD1 MCHR1 MGAT5B MOAP1 MORF4L2 MTMR10 MYCBP2 N4BP2L2 NAPA NEUROD2 OLR1 PICK1 PITHD1 PPP1R16B PTPRA PTPRD RAB5B RABEP1 SH2B1 SLC6A1 SMARCE1 SMYD2 SNRNP48 SNRNP70 SORBS1 SPARCL1 STMN1 STUB1 TAF1 TOMM6 TRIM68 TTC28 UBE2O USP8 VCPIP1 VPS35L VSNL1 ZBTB44 ZNF197 ZNF292 ZNF343 ZNF655 ZNF662 ZNF76 ZNF793	37 interacting genes: ATPAF2 CDCA7L CEP55 CEP70 CRX DSCAM DVL2 DVL3 FAM83A FARS2 FLYWCH1 GATA1 GFAP GOLGA2 HAPLN2 HUNK IKZF3 KCTD9 MAGOH MISP NEFL PATZ1 PHC2 PLEKHN1 RBPMS RFC5 SCNM1 SF3B4 SHC3 TACO1 TADA2A TASOR2 TFIP11 TLE5 TXN2 ZNF410 ZNF564
Entrez ID		30811	26051
HPRD ID		09410	15168
Ensembl ID		ENSG00000142149	ENSG00000101445
Uniprot IDs		P57058	Q96T49
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of RNA Biosynthetic Process DeNEDDylase Activity
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