HUNK and RABEP1

Number of citations of the paper that reports this interaction (PubMedID 11129044)
0

Data Source:
HPRD (two hybrid)

		HUNK	RABEP1
Description		hormonally up-regulated Neu-associated kinase	rabaptin, RAB GTPase binding effector protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytoplasm Endosome Early Endosome Cytosol Endocytic Vesicle Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Recycling Endosome Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	GTPase Activator Activity Protein Binding Growth Factor Activity Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process	Signal Transduction Intracellular Signal Transduction	Golgi To Plasma Membrane Transport Endocytosis Apoptotic Process Signal Transduction Protein Transport Vesicle-mediated Transport Membrane Fusion Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Protein Localization To Ciliary Membrane
Pathways			TBC/RABGAPs
Drugs
Diseases
GWAS		Crohn's disease ( 32581322) Joint damage progression in ACPA-negative rheumatoid arthritis ( 26077402) LDL cholesterol levels in HIV infection ( 33109212) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Type 2 diabetes ( 21490949) Vitiligo ( 19890347)	Body mass index ( 25673413 28892062) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Red blood cell density in sickle cell anemia ( 28552477) White blood cell count ( 27863252)
Interacting Genes		92 interacting genes: AARS1 ABLIM1 ACTR8 AGAP3 AIP AKAP8L AKR1C3 ALAD ANXA7 APBA2 APPL2 ARMCX4 ASCL1 ASPA ATP5F1B BIN1 CAMK1 CCAR1 CLU COG2 COPA COPS4 COPS5 CTDSP1 CTR9 CXXC5 DIS3L DLAT DLST DNAJA1 DST EEF1A2 EFNA1 EIF4G1 EPRS1 GEN1 HEATR6 HEY1 IFT81 IFT88 KDM6A KIF3A LIMK1 LNX1 LRSAM1 LURAP1 MAGED1 MBD1 MCHR1 MGAT5B MOAP1 MORF4L2 MTMR10 MYCBP2 N4BP2L2 NAPA NEUROD2 OLR1 PICK1 PITHD1 PPP1R16B PTPRA PTPRD RAB5B RABEP1 SH2B1 SLC6A1 SMARCE1 SMYD2 SNRNP48 SNRNP70 SORBS1 SPARCL1 STMN1 STUB1 TAF1 TOMM6 TRIM68 TTC28 UBE2O USP8 VCPIP1 VPS35L VSNL1 ZBTB44 ZNF197 ZNF292 ZNF343 ZNF655 ZNF662 ZNF76 ZNF793	60 interacting genes: ABI2 AIMP2 AP1G1 AP1G2 ATXN7 BARD1 CASP3 CCDC120 CCND1 CDC73 CDK18 CDKL3 CEP57 CFAP53 ELOA ESCO2 FAM50B FAM90A1 GAP43 GGA1 GGA2 GGA3 HUNK ITSN1 LENG1 MAT2B MCRS1 NRIP1 ODAD3 PELI2 PKP2 PRPF3 RAB1A RAB33B RAB4A RAB4B RAB5A RABGEF1 RGS17 RNF39 SMURF1 SNAPIN SNCA SNW1 SRPK2 STAR TNS4 TRAPPC2L TRIM26 TSC2 TSHZ2 UBC UBTFL1 USP2 UTP14C WASHC3 YWHAG ZNF438 ZNF512B ZNF774
Entrez ID		30811	9135
HPRD ID		09410	04684
Ensembl ID		ENSG00000142149	ENSG00000029725
Uniprot IDs		P57058	B4DMM4 Q15276
PDB IDs			1P4U 1TU3 1X79 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of RNA Biosynthetic Process DeNEDDylase Activity	Intracellular Protein Localization Vesicle-mediated Transport Golgi Vesicle Transport Protein Binding Early Endosome Membrane Protein Transport Establishment Of Protein Localization Endosome Intracellular Transport Regulation Of Vesicle-mediated Transport G Protein Activity Recycling Endosome Cellular Localization Establishment Of Localization In Cell Vesicle-mediated Transport In Synapse Intracellular Protein Transport Rab Protein Signal Transduction Post-Golgi Vesicle-mediated Transport Endosomal Transport Intracellular Vesicle Regulation Of Exocytosis Small GTPase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction GTPase Activity Early Endosome Post-translational Protein Modification Protein Localization To Cell Surface Presynapse Insulin-responsive Compartment Negative Regulation Of Exocytosis Golgi To Plasma Membrane Protein Transport Vacuolar Transport Synaptic Vesicle Endocytosis Cytoplasmic Vesicle Membrane Protein Localization To Organelle Nucleus Secretion Protein Modification Process Secretion By Cell Protein Polyubiquitination Presynaptic Endocytosis Regulation Of MRNA 3'-end Processing Endosome Membrane Protein Localization To Plasma Membrane Positive Regulation Of Translational Initiation Regulation Of Endosome Size Regulation Of Cellular Component Organization Exocytosis AP-1 Adaptor Complex
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