HUNK and CXXC5

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HUNK	CXXC5
Description		hormonally up-regulated Neu-associated kinase	CXXC finger protein 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	DNA Binding Zinc Ion Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Signal Transduction Intracellular Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy
Pathways			Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Crohn's disease ( 32581322) Joint damage progression in ACPA-negative rheumatoid arthritis ( 26077402) LDL cholesterol levels in HIV infection ( 33109212) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Type 2 diabetes ( 21490949) Vitiligo ( 19890347)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413) Hip circumference adjusted for BMI ( 34021172) Ovarian cancer ( 30557369) Refractive error ( 32231278)
Interacting Genes		92 interacting genes: AARS1 ABLIM1 ACTR8 AGAP3 AIP AKAP8L AKR1C3 ALAD ANXA7 APBA2 APPL2 ARMCX4 ASCL1 ASPA ATP5F1B BIN1 CAMK1 CCAR1 CLU COG2 COPA COPS4 COPS5 CTDSP1 CTR9 CXXC5 DIS3L DLAT DLST DNAJA1 DST EEF1A2 EFNA1 EIF4G1 EPRS1 GEN1 HEATR6 HEY1 IFT81 IFT88 KDM6A KIF3A LIMK1 LNX1 LRSAM1 LURAP1 MAGED1 MBD1 MCHR1 MGAT5B MOAP1 MORF4L2 MTMR10 MYCBP2 N4BP2L2 NAPA NEUROD2 OLR1 PICK1 PITHD1 PPP1R16B PTPRA PTPRD RAB5B RABEP1 SH2B1 SLC6A1 SMARCE1 SMYD2 SNRNP48 SNRNP70 SORBS1 SPARCL1 STMN1 STUB1 TAF1 TOMM6 TRIM68 TTC28 UBE2O USP8 VCPIP1 VPS35L VSNL1 ZBTB44 ZNF197 ZNF292 ZNF343 ZNF655 ZNF662 ZNF76 ZNF793	14 interacting genes: ATM DSCAM DSCR9 HUNK KCNJ6 RCAN1 RSPH1 SKIL SMAD3 SMAD5 SMAD7 SMAD9 UBASH3A VDR
Entrez ID		30811	51523
HPRD ID		09410	13105
Ensembl ID		ENSG00000142149	ENSG00000171604
Uniprot IDs		P57058	Q7LFL8
PDB IDs			5W9S
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of RNA Biosynthetic Process DeNEDDylase Activity	Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction SMAD Protein Complex Transforming Growth Factor Beta Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Regulator Complex Intracellular Signal Transduction Response To Growth Factor Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Cellular Developmental Process Tissue Development DEAD/H-box RNA Helicase Binding Kidney Epithelium Development Positive Regulation Of Cell Differentiation Cellular Response To Growth Factor Stimulus Lens Fiber Cell Differentiation Regulation Of Cell Differentiation Regulation Of Ossification Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Osteoblast Differentiation Striated Muscle Tissue Development Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cartilage Development Signal Transduction Positive Regulation Of Developmental Process Cell-cell Junction Organization Cell Junction Organization Intracellular Signaling Cassette Germ Cell Development Cell Development Developmental Process Involved In Reproduction Negative Regulation Of Signal Transduction Positive Regulation Of Bone Mineralization Negative Regulation Of Ossification Somitogenesis Negative Regulation Of Signaling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Communication Anatomical Structure Morphogenesis Negative Regulation Of Transcription By RNA Polymerase II Tube Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Lung Blood Pressure Positive Regulation Of Biomineral Tissue Development
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