MYCBP2 and TBR1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		MYCBP2	TBR1
Description		MYC binding protein 2	T-box brain transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Cell Projection	Chromatin Nucleus
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Chromatin DNA Binding
	Biological Process	Axon Guidance Motor Neuron Axon Guidance Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Ubiquitination Branchiomotor Neuron Axon Guidance Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Protein Ubiquitination Regulation Of Protein Localization Circadian Regulation Of Gene Expression Negative Regulation Of Protein Catabolic Process Rhythmic Process Cell Morphogenesis Involved In Neuron Differentiation Neuromuscular Process Regulation Of Cytoskeleton Organization Axon Development Protein K48-linked Ubiquitination Regulation Of Axon Guidance	Conditioned Taste Aversion Cell Fate Specification Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Specification Of Animal Organ Identity Gene Expression Regulation Of Gene Expression Regulation Of Neuron Projection Development Amygdala Development Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Development Neuron Differentiation Hindbrain Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Axon Guidance
Pathways
Drugs
Diseases
GWAS		Chronotype ( 30696823) Iris heterochromicity ( 30895295) Morning person ( 30696823) Preeclampsia ( 23551011) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Educational attainment ( 25201988) Intelligence (MTAG) ( 29326435) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990)
Interacting Genes		50 interacting genes: AATF APPL1 ARL6IP5 ASB8 ATP13A2 BTG3 CALM1 CD81 CEBPA CFL1 CUEDC2 DHRS4L2 DSCR9 DYRK1A ERBB3 FHL3 FSCN1 HSP90AB1 HUNK IGFBP6 LCOR LDHB LSM14A MYC NDUFB9 NMNAT2 OAZ1 PABPN1 PI4KB PRXL2A PTPN12 PUF60 RGPD8 RPS5 RSPH1 SERPINB6 SOD1 SPARCL1 SPRYD3 SRPK2 TBC1D9 TBC1D9B TBR1 TTN UBE2D2 UBE2D3 UBE2L3 UCHL1 YWHAG YWHAQ	7 interacting genes: CASK FOXP2 HNF1B HOXA1 MYCBP2 NFIC NFIX
Entrez ID		23077	10716
HPRD ID		10104	07055
Ensembl ID		ENSG00000005810	ENSG00000136535
Uniprot IDs		O75592	Q16650
PDB IDs		5O6C 6T7F
Enriched GO Terms of Interacting Partners?		Cytoplasm Intracellular Signal Transduction	DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Tube Formation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Artery Development Anatomical Structure Morphogenesis Regulation Of Transcription By RNA Polymerase II Genitalia Development Macromolecule Biosynthetic Process Transcription Coregulator Binding Gene Expression Nervous System Process Tube Morphogenesis Semicircular Canal Formation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Artery Morphogenesis Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Putamen Development Caudate Nucleus Development Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Abducens Nerve Formation Optokinetic Behavior Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Hepatoblast Differentiation Regulation Of Pronephros Size Blood Vessel Morphogenesis DNA Binding Neuromuscular Process Regulation Of RNA Metabolic Process Folate Transmembrane Transport
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