HUNK and SH2B1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HUNK	SH2B1
Description		hormonally up-regulated Neu-associated kinase	SH2B adaptor protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity
	Biological Process	Signal Transduction Intracellular Signal Transduction	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Mitotic Nuclear Division Cell Motility Positive Regulation Of SMAD Protein Signal Transduction Regulation Of DNA Biosynthetic Process
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Crohn's disease ( 32581322) Joint damage progression in ACPA-negative rheumatoid arthritis ( 26077402) LDL cholesterol levels in HIV infection ( 33109212) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Type 2 diabetes ( 21490949) Vitiligo ( 19890347)	Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 19079260 29381148 28448500 19079261 20935630) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908 21102463) Dental caries (decayed, missing and filled teeth) ( 31533690) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Lamb consumption ( 32066663) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Obesity ( 23563607) QT interval ( 29213071) Red blood cell count ( 32888494 27863252) Waist circumference ( 25673412) Weight ( 19079260)
Interacting Genes		92 interacting genes: AARS1 ABLIM1 ACTR8 AGAP3 AIP AKAP8L AKR1C3 ALAD ANXA7 APBA2 APPL2 ARMCX4 ASCL1 ASPA ATP5F1B BIN1 CAMK1 CCAR1 CLU COG2 COPA COPS4 COPS5 CTDSP1 CTR9 CXXC5 DIS3L DLAT DLST DNAJA1 DST EEF1A2 EFNA1 EIF4G1 EPRS1 GEN1 HEATR6 HEY1 IFT81 IFT88 KDM6A KIF3A LIMK1 LNX1 LRSAM1 LURAP1 MAGED1 MBD1 MCHR1 MGAT5B MOAP1 MORF4L2 MTMR10 MYCBP2 N4BP2L2 NAPA NEUROD2 OLR1 PICK1 PITHD1 PPP1R16B PTPRA PTPRD RAB5B RABEP1 SH2B1 SLC6A1 SMARCE1 SMYD2 SNRNP48 SNRNP70 SORBS1 SPARCL1 STMN1 STUB1 TAF1 TOMM6 TRIM68 TTC28 UBE2O USP8 VCPIP1 VPS35L VSNL1 ZBTB44 ZNF197 ZNF292 ZNF343 ZNF655 ZNF662 ZNF76 ZNF793	19 interacting genes: CRK CSAD EGFR ERBB2 ERBB3 ERBB4 FGFR3 FRS3 GRB2 HUNK IGF1R INSR JAK2 KIAA0319 MET NTRK1 NTRK2 RHBG SH2B2
Entrez ID		30811	25970
HPRD ID		09410	12336
Ensembl ID		ENSG00000142149	ENSG00000178188
Uniprot IDs		P57058	B3KNV5 B4DLN5 Q9NRF2
PDB IDs			5W3R
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of RNA Biosynthetic Process DeNEDDylase Activity	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Receptor Complex Protein Kinase Activity Kinase Activity Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Insulin Receptor Substrate Binding Peptidyl-tyrosine Phosphorylation ATP Binding Protein Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane ERBB2 Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Plasma Membrane ERBB Signaling Pathway Nucleotide Binding Transferase Activity Response To Growth Factor Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Phosphorylation Neuron Differentiation Signal Transduction Phosphorylation Regulation Of Signal Transduction Cell Development Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Identical Protein Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Endosome Regulation Of Cell Communication Regulation Of Signaling Phosphatidylinositol 3-kinase Binding Cellular Developmental Process Positive Regulation Of Phosphate Metabolic Process Schwann Cell Development ERBB3:ERBB2 Complex Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation
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