HUNK and ALAD

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HUNK	ALAD
Description		hormonally up-regulated Neu-associated kinase	aminolevulinate dehydratase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Catalytic Activity Porphobilinogen Synthase Activity Zinc Ion Binding Lyase Activity Identical Protein Binding Metal Ion Binding Proteasome Core Complex Binding
	Biological Process	Signal Transduction Intracellular Signal Transduction	Response To Hypoxia Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Oxidative Stress Response To Nutrient Response To Xenobiotic Stimulus Response To Herbicide Response To Toxic Substance Response To Hormone Response To Metal Ion Response To Iron Ion Response To Zinc Ion Response To Aluminum Ion Response To Ionizing Radiation Response To Vitamin B1 Response To Selenium Ion Response To Lead Ion Response To Activity Response To Nutrient Levels Response To Cobalt Ion Response To Lipopolysaccharide Tetrapyrrole Biosynthetic Process Response To Vitamin E Response To Vitamin Response To Amino Acid Response To Ethanol Response To Arsenic-containing Substance Response To Cadmium Ion Response To Mercury Ion Heme O Biosynthetic Process Protein Homooligomerization Response To Glucocorticoid Response To Methylmercury Response To Platinum Ion Response To Fatty Acid Cellular Response To Lead Ion Cellular Response To Interleukin-4 Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways			Heme biosynthesis Neutrophil degranulation
Drugs			Aminolevulinic acid Delta-Amino Valeric Acid Laevulinic Acid 4-Oxosebacic Acid Porphobilinogen 3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid 4,7-Dioxosebacic Acid 5-hydroxyvaleric acid
Diseases			Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS		Crohn's disease ( 32581322) Joint damage progression in ACPA-negative rheumatoid arthritis ( 26077402) LDL cholesterol levels in HIV infection ( 33109212) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Type 2 diabetes ( 21490949) Vitiligo ( 19890347)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lead levels in blood ( 25820613) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		92 interacting genes: AARS1 ABLIM1 ACTR8 AGAP3 AIP AKAP8L AKR1C3 ALAD ANXA7 APBA2 APPL2 ARMCX4 ASCL1 ASPA ATP5F1B BIN1 CAMK1 CCAR1 CLU COG2 COPA COPS4 COPS5 CTDSP1 CTR9 CXXC5 DIS3L DLAT DLST DNAJA1 DST EEF1A2 EFNA1 EIF4G1 EPRS1 GEN1 HEATR6 HEY1 IFT81 IFT88 KDM6A KIF3A LIMK1 LNX1 LRSAM1 LURAP1 MAGED1 MBD1 MCHR1 MGAT5B MOAP1 MORF4L2 MTMR10 MYCBP2 N4BP2L2 NAPA NEUROD2 OLR1 PICK1 PITHD1 PPP1R16B PTPRA PTPRD RAB5B RABEP1 SH2B1 SLC6A1 SMARCE1 SMYD2 SNRNP48 SNRNP70 SORBS1 SPARCL1 STMN1 STUB1 TAF1 TOMM6 TRIM68 TTC28 UBE2O USP8 VCPIP1 VPS35L VSNL1 ZBTB44 ZNF197 ZNF292 ZNF343 ZNF655 ZNF662 ZNF76 ZNF793	1 interacting genes: HUNK
Entrez ID		30811	210
HPRD ID		09410	00504
Ensembl ID		ENSG00000142149	ENSG00000148218
Uniprot IDs		P57058	A0A140VJL9 B7Z3I9 P13716 Q6ZMU0
PDB IDs			1E51 1PV8 5HMS 5HNR
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Protein Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of RNA Biosynthetic Process DeNEDDylase Activity	CHRAC Epsilon DNA Polymerase Complex Leading Strand Elongation DNA Strand Elongation Involved In DNA Replication ATAC Complex DNA-directed DNA Polymerase Activity DNA Strand Elongation Pericentric Heterochromatin
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