WT1 and TP63

Number of citations of the paper that reports this interaction (PubMedID 10744705)
0

Data Source:
HPRD (in vitro, in vivo)

		WT1	TP63
Description		WT1 transcription factor	tumor protein p63
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck	Chromatin Nucleus Nucleoplasm Cytoplasm Dendrite Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding Metal Ion Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding WW Domain Binding MDM2/MDM4 Family Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of Animal Organ Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Germ Cell Development Thorax And Anterior Abdomen Determination Heart Development Sex Determination Negative Regulation Of Cell Population Proliferation RNA Splicing Gonad Development Male Gonad Development Tissue Development Positive Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of Cell Growth Adrenal Gland Development Male Genitalia Development Epithelial Cell Differentiation Glomerulus Development Glomerular Basement Membrane Development Adrenal Cortex Formation Camera-type Eye Development Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Cardiac Muscle Cell Fate Commitment Visceral Serous Pericardium Development Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Metanephric Mesenchyme Development Nephron Tubule Morphogenesis Podocyte Differentiation Posterior Mesonephric Tubule Development Metanephric Epithelium Development Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Circulatory System Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development Positive Regulation Of Metanephric Ureteric Bud Development	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Establishment Of Planar Polarity Morphogenesis Of A Polarized Epithelium Hair Follicle Development Epithelial Cell Development Chromatin Remodeling Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Apoptotic Process DNA Damage Response Notch Signaling Pathway Spermatogenesis Pattern Specification Process Ectoderm And Mesoderm Interaction Positive Regulation Of Cell Population Proliferation Determination Of Adult Lifespan Epidermis Development Animal Organ Morphogenesis Epidermal Cell Differentiation Proximal/distal Pattern Formation Epidermal Cell Division Regulation Of Epidermal Cell Division Positive Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Embryonic Limb Morphogenesis Prostate Gland Development Epithelial Cell Differentiation Polarized Epithelial Cell Differentiation Hair Follicle Morphogenesis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Post-anal Tail Morphogenesis Odontogenesis Of Dentin-containing Tooth Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Skin Morphogenesis Keratinocyte Proliferation Positive Regulation Of Cell Differentiation Negative Regulation Of Keratinocyte Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Sympathetic Nervous System Development Anatomical Structure Formation Involved In Morphogenesis Female Genitalia Morphogenesis Stem Cell Differentiation Protein Tetramerization Neuron Apoptotic Process Cloacal Septation Prostatic Bud Formation Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Establishment Of Skin Barrier Stem Cell Proliferation Cellular Senescence Skin Epidermis Development Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Somatic Stem Cell Population Maintenance Cranial Skeletal System Development Positive Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Mesoderm Development Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Transcriptional regulation of testis differentiation Negative Regulation of CDH1 Gene Transcription Nephron development	Activation of PUMA and translocation to mitochondria Pyroptosis TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD	Split-hand/foot malformation (SHFM) Limb-mammary syndrome Ectrodactyly-ectodermal dysplasia cleft-palate syndrome (EEC syndrome) ADULT syndrome Ankyloblepharon-ctodermal defects-cleft lip/palate (AEC) syndrome and Rapp-Hodgkin syndrome Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS		Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Brugada syndrome ( 35210625) Coronary artery disease ( 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Inguinal hernia ( 26686553) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Pelvic organ prolapse ( 32184442) PR interval ( 32439900) Pulse pressure ( 30224653) Resting-state electroencephalogram vigilance ( 29703947) Rubella-specific interleukin-6 secretion ( 29253144) Tuberculosis ( 24057671 22306650) Uterine fibroids ( 31649266 31249589 30194396) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Acute lymphoblastic leukemia (childhood) ( 22076464) Bladder cancer ( 24163127 20972438) Brain imaging ( 20100581) Chlamydia trachomatis PorB antibody levels ( 33204752) Circulating leptin levels in high cardiovascular risk ( 31766143) Cutaneous squamous cell carcinoma ( 32041948) EGFR mutation-positive lung adenocarcinoma ( 27501781) Lung adenocarcinoma ( 20871597 28604730 22797724) Lung cancer ( 24880342 23143601 28604730 21725308) Lung cancer in never smokers ( 31009812) Metabolite levels ( 23823483) Non-small cell lung cancer ( 31326317) Pancreatic cancer ( 26098869 29422604) Postoperative stroke after cardiac surgery ( 30678657) Psoriasis ( 25903422) Psoriasis vulgaris ( 26626624) Serum CC16 levels ( 32839289) Squamous cell carcinoma ( 26829030) Systemic lupus erythematosus ( 28714469) Urinary bladder cancer ( 20348956 18794855)
Interacting Genes		66 interacting genes: AREG BHLHE40 CASZ1 CCDC136 CCDC33 CCL5 CEP70 CIAO1 CREBBP CYSRT1 DIRAS3 DVL2 DVL3 EGR1 ETV7 FAM9B FHL2 FMR1NB GLIS2 GOLGA2 HMBOX1 IDI1 IPO8 KLK7 KPNA4 KPNA5 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 LDOC1 MAGEA8 MDM2 MYC NAT2 NPM3 OGT OSBPL3 PAWR PAX2 PICK1 PRKACA RNASEH2B SERF2 SOX4 STK11 TAOK1 THAP1 THRSP TP53 TP63 TP73 TRIM55 TRIM63 U2AF2 UBE2I WTAP WTIP YAP1 ZNF205 ZRANB1	43 interacting genes: BAG6 BTRC CCNC CDC20 CDKN2A COPS6 CSNK2A1 CSNK2A2 CSNK2B DAXX EMX1 EP300 GCGR GRB2 HIPK2 HNRNPAB HP HPX ITIH4 KAT2B MCRS1 MDM4 NEDD4 NIPSNAP3A ORM1 PELI1 PELI2 PIN1 PINX1 PML PPP1R13B PPP2R5A RACK1 RCHY1 SCAF4 SLC35A3 STUB1 TP53 TP73 UBASH3A UBE2I WT1 YAP1
Entrez ID		7490	8626
HPRD ID		06163	04469
Ensembl ID		ENSG00000184937	ENSG00000073282
Uniprot IDs		A0A481V744 H0Y7K5 P19544 Q6PI38	A0A0S2Z4N5 A0A0S2Z4N6 A0A141PNN3 A0A141PNN4 B7Z8X6 C9D7D0 Q9H3D4
PDB IDs		1XF7 2JP9 2JPA 2PRT 3HPJ 3MYJ 4R2E 4R2P 4R2Q 4R2R 4R2S 4WUU 5KL2 5KL3 5KL4 5KL5 5KL6 5KL7 6B0O 6B0P 6B0Q 6B0R 6BLW 6RSY 6WLH 7BBG 8ISN	1RG6 2NB1 2RMN 2Y9T 2Y9U 3QYM 3QYN 3US0 3US1 3US2 3ZY0 3ZY1 4A9Z 6FGN 6RU6 6RU7 6RU8 7Z71 7Z72 7Z73 7Z7E 8P9C 8P9D 8P9E 9GFO
Enriched GO Terms of Interacting Partners?		Keratin Filament Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intermediate Filament Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process P53 Binding Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Nuclear Body Nucleoplasm Regulation Of Transcription By RNA Polymerase II Cellular Response To Gamma Radiation Cellular Response To Radiation Chromatin Identical Protein Binding Epithelial Cell Proliferation Regulation Of Stem Cell Population Maintenance Regulation Of Somatic Stem Cell Population Maintenance MDM2/MDM4 Family Protein Binding Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Cellular Response To UV Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Actinomycin D Cell Population Proliferation Positive Regulation Of Lymphocyte Apoptotic Process Nucleus Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Signal Transduction By P53 Class Mediator Response To Gamma Radiation Transcription Factor Binding Regulation Of Metabolic Process Regulation Of Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of MiRNA Transcription Cytosol Cellular Response To Light Stimulus Response To Actinomycin D PML Body	Regulation Of Protein Metabolic Process Negative Regulation Of Catabolic Process Regulation Of Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Regulation Of Primary Metabolic Process Cellular Response To Stress DNA Damage Response Regulation Of Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Macromolecule Metabolic Process Signal Transduction By P53 Class Mediator Positive Regulation Of Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Protein Modification Process Negative Regulation Of Metabolic Process P53 Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Protein Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Negative Regulation Of Proteolysis Nucleus Regulation Of Cellular Response To Stress Apoptotic Signaling Pathway Protein Stabilization Protein Modification By Small Protein Conjugation Negative Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Protein Kinase CK2 Complex Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Stress Protein Metabolic Process Post-translational Protein Modification Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Negative Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process
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